関: vessel

WordNet

a craft designed for water transportation (同)watercraft
an object used as a container (especially for liquids)
a tube in which a body fluid circulates (同)vas

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(比較的大型の)『船』 / (特に液体を入れる)容器,器 / (動植物の)『管』,導管,脈管

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/30 19:56:19」(JST)

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Sulodexide is a highly purified mixture of glycosaminoglycans composed of low molecular weight heparin (80%) and dermatan sulfate (20%).

Pharmacology

The low molecular weight of both sulodexide fractions allows for extensive oral absorption compared to unfractionated heparin. The pharmacological effects of sulodexide differ substantially from other glycosaminoglycans and are mainly characterized by a prolonged half-life and reduced effect on global coagulation and bleeding parameters.^[1] Due to the presence of both glycosaminoglycan fractions, sulodexide potentiates the antiprotease activities of both antithrombin III and heparin cofactor II simultaneously.^[2]

Uses

Clinically, sulodexide is used for the prophylaxis and treatment of thromboembolic diseases however recent research has also demonstrated the beneficial effects of sulodexide in animal models of reperfusion injury^[3] and the treatment of diabetic nephropathy.^[4]^[5]^[6] In combination with Melatonin, Sulodexide have been shown to be a viable treatment option for patients suffering from central or sensorineural tinnitus.^[7]^[8]

References

^ Lauver DA, Lucchesi BR (2006). "Sulodexide: a renewed interest in this glycosaminoglycan". Cardio drug rev 24 (3-4): 214–26. doi:10.1111/j.1527-3466.2006.00214.x. PMID 17214598.
^ Harenberg J (1998). "Review of pharmacodynamics, pharmacokinetics, and therapeutic properties of sulodexide". Med Res Rev 18 (1): 1–20. doi:10.1002/(SICI)1098-1128(199801)18:1<1::AID-MED1>3.0.CO;2-4. PMID 9436179.
^ Lauver DA, Booth EA, White AJ, Poradosu E, Lucchesi BR (2005). "Sulodexide attenuates myocardial ischemia/reperfusion injury and the deposition of C-reactive protein in areas of infarction without affecting hemostasis". J Pharmacol Exp Ther 312 (2): 794–800. doi:10.1124/jpet.104.075283. PMID 15365091.
^ Achour A, Kacem M, Dibej K, Skhiri H, Bouraoui S, El May M. (2005). "One year course of oral sulodexide in the management of diabetic nephropathy". J Nephrol 18 (5): 568–574. PMID 16299683.
^ Gambaro G, Venturini AP, Noonan DM et al. (1994). "Treatment with a glycosaminoglycan formulation ameliorates experimental diabetic nephropathy". Kidney Int 46 (3): 797–806. doi:10.1038/ki.1994.335. PMID 7527876.
^ Škrhaa J, , J Perušičováb J et al. (1997). "Treatment with a glycosaminoglycan formulation ameliorates experimental diabetic nephropathy". Diabetes Res Clin Practice 38 (1): 25–31. doi:10.1016/S0168-8227(97)00076-4. PMID 9347243.
^ Neri G, Baffa C, De Stefano A et al. (2009). "Management of tinnitus: oral treatment with melatonin and sulodexide". J. Biol. Regul. Homeost. Agents 23 (2): 103–10. PMID 19589291.
^ Neri G. De Stefano A. Baffa C. Kulamarva G. Di Giovanni P. Petrucci G. Poliandri A. Dispenza F. Citraro L. Croce A. ,"Treatment of central and sensorineural tinnitus with orally administered Melatonin and Sulodexide: personal experience from a randomized controlled study." Acta Otorhinolaryngologica Italica. 29(2):86-91, 2009 Apr.

External links

sulodexide at the US National Library of Medicine Medical Subject Headings (MeSH)

This drug article relating to the blood and blood forming organs is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 下肢慢性静脈疾患の内科的マネージメント medical management of lower extremity chronic venous disease
2. 糖尿病性腎症の治療 treatment of diabetic nephropathy

English Journal

Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases.

Becker BF1, Jacob M, Leipert S, Salmon AH, Chappell D.
British journal of clinical pharmacology.Br J Clin Pharmacol.2015 Mar 16. doi: 10.1111/bcp.12629. [Epub ahead of print]
The endothelial glycocalyx has a profound influence at the vascular wall on the transmission of shear stress, on the maintenance of a selective permeability barrier and a low hydraulic conductivity, and on attenuating firm adhesion of blood leukocytes and platelets. Major constituents of the glycoca
PMID 25778676

Clinical pharmacology of melatonin in the treatment of tinnitus: a review.

Miroddi M1, Bruno R, Galletti F, Calapai F, Navarra M, Gangemi S, Calapai G.
European journal of clinical pharmacology.Eur J Clin Pharmacol.2015 Mar;71(3):263-70. doi: 10.1007/s00228-015-1805-3. Epub 2015 Jan 20.
PURPOSE: We performed a review with the purpose to summarise, analyse and discuss the evidence provided by clinical studies evaluating effectiveness of melatonin in the cure of tinnitus. Due to the fact that there is no satisfactory treatment for tinnitus, clinical research has explored new therapeu
PMID 25597877

Leg ulcer and osteomyelitis due to methicillin-susceptible Staphylococcus aureus infection after fracture repair treatment: a case highlighting the potential role of prostaglandin E1 vasodilator.

Bentivegna E1, Citarrella E1, Vivaldi R1, De Luca D1, Maira GG1, Casuccio A1, Di Carlo P1.
Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive.Infez Med.2015 Mar 1;23(1):69-73.
Prostaglandins appear to reduce biofilm formation and chronicization of infections, and stimulate a rapid and effective clearance of infecting micro-organisms. We report a case of recovery from methicillin-susceptible Staphylococcus aureus (MSSA) osteomyelitis after multidisciplinary management with
PMID 25819055

Japanese Journal

Vascular dementia Italian sulodexide study (VA.D.I.S.S.). Clinical and biological results.

PARNETTI L.
Thromb Res 87, 225-233, 1997
NAID 30006324401

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リンク元

「vessel」

Sulodexide
Systematic (IUPAC) name
	Glucurono-2-amino-2-deoxyglucoglucan sulfate
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral, Subcutaneous, Intravenous, Intramuscular
Identifiers
CAS Registry Number	57821-29-1
ATC code	B01AB11
DrugBank	DB06271
KEGG	D08547
Chemical data
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　　[★]

n.

血管、(植物)導管、道管、(一般)容器

関: angio、blood vessel、canal、chamber、conduit、container、duct、sulodexide、vas、vascular、vein

[1] Lauver DA, Lucchesi BR (2006). "Sulodexide: a renewed interest in this glycosaminoglycan". Cardio drug rev 24 (3-4): 214–26. doi:10.1111/j.1527-3466.2006.00214.x. PMID 17214598.

[2] Harenberg J (1998). "Review of pharmacodynamics, pharmacokinetics, and therapeutic properties of sulodexide". Med Res Rev 18 (1): 1–20. doi:10.1002/(SICI)1098-1128(199801)18:1<1::AID-MED1>3.0.CO;2-4. PMID 9436179.

[3] Lauver DA, Booth EA, White AJ, Poradosu E, Lucchesi BR (2005). "Sulodexide attenuates myocardial ischemia/reperfusion injury and the deposition of C-reactive protein in areas of infarction without affecting hemostasis". J Pharmacol Exp Ther 312 (2): 794–800. doi:10.1124/jpet.104.075283. PMID 15365091.

[4] Achour A, Kacem M, Dibej K, Skhiri H, Bouraoui S, El May M. (2005). "One year course of oral sulodexide in the management of diabetic nephropathy". J Nephrol 18 (5): 568–574. PMID 16299683.

[5] Gambaro G, Venturini AP, Noonan DM et al. (1994). "Treatment with a glycosaminoglycan formulation ameliorates experimental diabetic nephropathy". Kidney Int 46 (3): 797–806. doi:10.1038/ki.1994.335. PMID 7527876.

[6] Škrhaa J, , J Perušičováb J et al. (1997). "Treatment with a glycosaminoglycan formulation ameliorates experimental diabetic nephropathy". Diabetes Res Clin Practice 38 (1): 25–31. doi:10.1016/S0168-8227(97)00076-4. PMID 9347243.

[7] Neri G, Baffa C, De Stefano A et al. (2009). "Management of tinnitus: oral treatment with melatonin and sulodexide". J. Biol. Regul. Homeost. Agents 23 (2): 103–10. PMID 19589291.

[8] Neri G. De Stefano A. Baffa C. Kulamarva G. Di Giovanni P. Petrucci G. Poliandri A. Dispenza F. Citraro L. Croce A. ,"Treatment of central and sensorineural tinnitus with orally administered Melatonin and Sulodexide: personal experience from a randomized controlled study." Acta Otorhinolaryngologica Italica. 29(2):86-91, 2009 Apr.

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sulodexide