スルファメトミジン
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/02/03 03:08:18」(JST)
[Wiki en表示]
Sulfametomidine
|
Systematic (IUPAC) name |
4-amino-N-(6-methoxy-2-methylpyrimidin-4-yl)
benzenesulfonamide |
Clinical data |
Pregnancy cat. |
? |
Legal status |
? |
Routes |
Oral |
Pharmacokinetic data |
Half-life |
27 hours |
Excretion |
Renal |
Identifiers |
CAS number |
3772-76-7 N |
ATC code |
J01ED03 |
PubChem |
CID 19596 |
ChemSpider |
18460 Y |
UNII |
940ZL3AHKB Y |
ChEMBL |
CHEMBL485940 Y |
Chemical data |
Formula |
C12H14N4O3S |
Mol. mass |
294.331 g/mol |
SMILES
- O=S(=O)(Nc1nc(nc(OC)c1)C)c2ccc(N)cc2
|
InChI
-
InChI=1S/C12H14N4O3S/c1-8-14-11(7-12(15-8)19-2)16-20(17,18)10-5-3-9(13)4-6-10/h3-7H,13H2,1-2H3,(H,14,15,16) Y
Key:QKLSCPPJEVXONT-UHFFFAOYSA-N Y
|
N (what is this?) (verify)
|
Sulfametomidine (or sulfamethomidine) is a sulfonamide antibacterial.
Antibacterials: nucleic acid inhibitors (J01E, J01M)
|
|
Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis) |
DHFR inhibitor |
- 2,4-Diaminopyrimidine
- Trimethoprim#
- Brodimoprim
- Tetroxoprim
- Iclaprim†
|
|
Sulfonamides
(DHPS inhibitor) |
Short-
acting |
- Sulfaisodimidine
- Sulfamethizole
- Sulfadimidine
- Sulfapyridine
- Sulfafurazole
- Sulfanilamide
- Sulfathiazole
- Sulfathiourea
|
|
Intermediate-
acting |
- Sulfamethoxazole
- Sulfadiazine#
- Sulfamoxole
|
|
Long-
acting |
- Sulfadimethoxine
- Sulfadoxine
- Sulfalene
- Sulfametomidine
- Sulfametoxydiazine
- Sulfamethoxypyridazine
- Sulfaperin
- Sulfamerazine
- Sulfaphenazole
- Sulfamazone
|
|
|
Other/ungrouped |
- sulfanilamide
- Sulfacetamide
- Sulfametrole
|
|
Combinations |
- Trimethoprim/sulfamethoxazole#
|
|
|
Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication) |
1st g. |
- Cinoxacin‡
- Flumequine
- Nalidixic acid
- Oxolinic acid
- Pipemidic acid
- Piromidic acid
- Rosoxacin
|
|
Fluoro-
quinolones |
2nd g. |
- Ciprofloxacin#
- Enoxacin‡
- Fleroxacin‡
- Lomefloxacin
- Nadifloxacin
- Ofloxacin
- Norfloxacin
- Pefloxacin
- Rufloxacin
|
|
3rd g. |
- Balofloxacin
- Grepafloxacin‡
- Levofloxacin
- Pazufloxacin
- Sparfloxacin‡
- Temafloxacin‡
- Tosufloxacin
|
|
4th g. |
- Besifloxacin
- Clinafloxacin†
- Garenoxacin
- Gemifloxacin
- Moxifloxacin
- Gatifloxacin‡
- Sitafloxacin
- Trovafloxacin‡/Alatrofloxacin‡
- Prulifloxacin
|
|
Vet. |
- Danofloxacin
- Difloxacin
- Enrofloxacin
- Ibafloxacin
- Marbofloxacin
- Orbifloxacin
- Pradofloxacin
- Sarafloxacin
|
|
Related (DG) |
- Aminocoumarins: Novobiocin
|
|
|
|
Anaerobic DNA
inhibitors |
Nitro- imidazole derivatives |
- Metronidazole#
- Tinidazole
- Ornidazole
|
|
Nitrofuran derivatives |
- Nitrofurantoin#
- Furazolidone‡
- Nifurtoinol
|
|
|
RNA synthesis |
Rifamycins/
RNA polymerase |
- Rifampicin#
- Rifabutin
- Rifapentine
- Rifaximin
|
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
gr+f/gr+a (t)/gr-p (c)/gr-o
|
drug (J1p, w, n, m, vacc)
|
|
|
|
English Journal
- Contribution of the human kidney to the metabolic clearance of drugs.
- Vree TB, Hekster YA, Anderson PG.Author information Department of Clinical Pharmacy, Sint Radboud Hospital, Nijmegen, The Netherlands.AbstractOBJECTIVE: To demonstrate that the human kidney is capable not only of filtering and secreting drugs and their metabolites, but also of carrying out conjugation reactions such as acyl glucuronidation, N-glucuronidation, and glycination.
- The Annals of pharmacotherapy.Ann Pharmacother.1992 Nov;26(11):1421-8.
- OBJECTIVE: To demonstrate that the human kidney is capable not only of filtering and secreting drugs and their metabolites, but also of carrying out conjugation reactions such as acyl glucuronidation, N-glucuronidation, and glycination.DATA SOURCES: Plasma concentrations and renal excretion rates of
- PMID 1477449
- [Comparison of the in vitro dissolution and the absorption of sulfametomidine and its solvates].
- Audran M, Lasserre Y, Rambaud J, Pauvert B, Berge G, Maury L.
- Pharmaceutica acta Helvetiae.Pharm Acta Helv.1988;63(12):343-6.
- PMID 3241815
Related Links
- Drugs in your Drinking Water In the Associated Press they did a report that over 41 million people are exposed to pharmaceutical drugs in TREATED drinking water. We have all ... shared by GRgirl764
- Visit ChemicalBook To find more sulfametomidine(3772-76-7) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs ...
Related Pictures