- 関
- succinylate
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/10/04 04:06:35」(JST)
[Wiki en表示]
Succinylation is a posttranslational modification where a succinyl group (-CO-CH2-CH2-CO-) is added to a lysine residue of a protein molecule. This modification is found in many proteins, including histones.[1] The potential role of succinylation is under investigation, but as addition of succinyl group changes lysine's charge from +1 to −1 and introduces a relatively large structural moiety (bigger than during acetylation or methylation), it is expected to lead to more significant changes in protein structure and function.[2]
By analogy to acetylation, it has been suggested that succinyl-CoA is the cofactor of enzyme-mediated lysine succinylation.
References
- ^ Xie, Z.; Dai, J.; Dai, L.; Tan, M.; Cheng, Z.; Wu, Y.; Boeke, J. D.; Zhao, Y. (2012). "Lysine succinylation and lysine malonylation in histones". Molecular & Cellular Proteomics. 11 (5): 100–7. doi:10.1074/mcp.M111.015875. PMID 22389435.
- ^ Zhang, Z.; Tan, M.; Xie, Z.; Dai, L.; Chen, Y.; Zhao, Y. (2010). "Identification of lysine succinylation as a new post-translational modification". Nature Chemical Biology. 7 (1): 58–63. doi:10.1038/nchembio.495. PMC 3065206. PMID 21151122.
External links
- Succinylation, Yet A Novel PTM Pathway for Biological Regulation, But Ready to Be Investigated
- Succinyl group at ChEBI
Protein primary structure and posttranslational modifications
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General |
- Peptide bond
- Protein biosynthesis
- Proteolysis
- Racemization
- N-O acyl shift
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N terminus |
- Acetylation
- Carbamylation
- Formylation
- Glycation
- Methylation
- Myristoylation (Gly)
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C terminus |
- Amidation
- Glycosyl phosphatidylinositol (GPI)
- O-methylation
- Detyrosination
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Single specific AAs |
Serine/Threonine
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- Phosphorylation
- Dephosphorylation
- Glycosylation
- Methylidene-imidazolone (MIO) formation
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Tyrosine
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- Phosphorylation
- Dephosphorylation
- Sulfation
- Porphyrin ring linkage
- Adenylylation
- Flavin linkage
- Topaquinone (TPQ) formation
- Detyrosination
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Cysteine
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- Palmitoylation
- Prenylation
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Aspartate
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Glutamate
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- Carboxylation
- Methylation
- Polyglutamylation
- Polyglycylation
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Asparagine
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- Deamidation
- Glycosylation
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Glutamine
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Lysine
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- Methylation
- Acetylation
- Acylation
- Adenylylation
- Hydroxylation
- Ubiquitination
- Sumoylation
- ADP-ribosylation
- Deamination
- Oxidative deamination to aldehyde
- O-glycosylation
- Imine formation
- Glycation
- Carbamylation
- Succinylation
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Arginine
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- Citrullination
- Methylation
- ADP-ribosylation
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Proline
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Histidine
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- Diphthamide formation
- Adenylylation
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Tryptophan
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Crosslinks between two AAs |
Cysteine-Cysteine
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Methionine-Hydroxylysine
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Lysine-Tyrosylquinone
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- Lysine tyrosylquinone (LTQ) formation
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Tryptophan-Tryptophylquinone
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- Tryptophan tryptophylquinone (TTQ) formation
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Three consecutive AAs
(chromophore formation) |
Serine–Tyrosine–Glycine
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- p-Hydroxybenzylidene-imidazolinone formation
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Histidine–Tyrosine–Glycine
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- 4-(p-hydroxybenzylidene)-5-imidazolinone formation
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Crosslinks between four AAs |
Allysine-Allysine-Allysine-Lysine
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English Journal
- Preparation of iron bound succinylated milk protein concentrate and evaluation of its stability.
- Shilpashree BG1, Arora S2, Sharma V3, Bajaj RK4, Tomar SK5.
- Food chemistry.Food Chem.2016 Apr 1;196:800-7. doi: 10.1016/j.foodchem.2015.10.020. Epub 2015 Nov 13.
- Major problems associated with the fortification of soluble iron salts include chemical reactivity and incompatibility with other components. Milk protein concentrate (MPC) are able to bind significant amount of iron due to the presence of both casein and whey protein. MPC in its native state posses
- PMID 26593557
- Green route to modification of wood waste, cellulose and hemicellulose using reactive extrusion.
- Vaidya AA1, Gaugler M2, Smith DA2.
- Carbohydrate polymers.Carbohydr Polym.2016 Jan 20;136:1238-50. doi: 10.1016/j.carbpol.2015.10.033. Epub 2015 Oct 22.
- A large volume of wood waste is produced in timber processing industry which traditionally used in low value applications. Here, value addition to the wood waste (Sander dust) and cellulose, hemicellulose isolated thereof by functionalisation using cyclic anhydrides in a solvent-free and green react
- PMID 26572467
- Effect of succinylation on functional and morphological properties of starches from broken kernels of Pakistani Basmati and Irri rice cultivars.
- Moin A1, Ali TM2, Hasnain A3.
- Food chemistry.Food Chem.2016 Jan 15;191:52-8. doi: 10.1016/j.foodchem.2015.03.119. Epub 2015 Apr 2.
- Starch extracted from broken kernels of Basmati and Irri rice varieties of Pakistani rice were subjected to modification by addition of succinic anhydride at levels of 2%, 4% and 5% based on dried weight of starch. The succinyl content of Irri rice starch increased with the concentration of succinic
- PMID 26258701
Japanese Journal
- Development of an Enzyme-Linked Immunosorbent Assay System to Determine the Presence of Antibodies Specific for Taxane Structures
- Muto Satoshi,Kouyama Yuichi,Yokoyama Yuusaku,Okuno Hiroaki,Ishii Toshihiro,Masaka Toru,Matsuzawa Yasuo,Kawashima Tatsuo,Shirai Koji
- Biological & Pharmaceutical Bulletin 34(4), 562-566, 2011
- … After the succinylation reaction, three different products were obtained, and these were confirmed as 7-succinoyl DAB (7-DAB), 10-succinoyl DAB (10-DAB), and 7,10-disuccinoyl DAB (7,10-DAB) by 1H-NMR analysis. …
- NAID 130000657848
- Succinylation-induced Conformational Destabilization of Lysozyme as Studied by Guanidine Hydrochloride Denaturation
- ONG Hui Nee,ARUMUGAM Bavani,TAYYAB Saad
- The journal of biochemistry 146(6), 895-904, 2009-12-01
- NAID 10026305463
Related Links
- Recent studies have shown that lysines can be posttranslationally modified by various types of acylations. However, except for acetylation, very little is known ... Introduction Advances in high-resolution mass spectrometry (MS) and ...
- ^Xie, Z.; Dai, J.; Dai, L.; Tan, M.; Cheng, Z.; Wu, Y.; Boeke, J. D.; Zhao, Y. (2012). "Lysine succinylation and lysine malonylation in histones". Molecular & Cellular Proteomics 11 (5): 100–7. doi:10.1074/mcp.M111.015875. PMID 22389435
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