English Journal

Tricin, 4',5,7-trihydroxy-3',5'-dimethoxyflavone, exhibits potent antiangiogenic activity in vitro.

Han JM1, Kwon HJ2, Jung HJ1.
International journal of oncology.Int J Oncol.2016 Oct;49(4):1497-504. doi: 10.3892/ijo.2016.3645. Epub 2016 Aug 3.
Tumor growth and metastasis depend on angiogenesis triggered by chemical signals, such as vascular endothelial growth factor (VEGF), released from tumor cells. Therefore, the specific perturbation of angiogenesis has been considered a powerful strategy for the treatment of cancer. Herein, we report
PMID 27498749

Sporoderm-Broken Spores of Ganoderma lucidum Inhibit the Growth of Lung Cancer: Involvement of the Akt/mTOR Signaling Pathway.

Chen Y1, Lv J2, Li K3, Xu J4, Li M5, Zhang W6, Pang X6.
Nutrition and cancer.Nutr Cancer.2016 Oct;68(7):1151-60. doi: 10.1080/01635581.2016.1208832. Epub 2016 Aug 11.
The sporoderm-broken spores of Ganoderma lucidum (SBGS) and their extracts exhibited a wide range of biological activities. In the present study, we prepare ethanol/ethanol extract (E/E-SBGS) and ethanol/aqueous extract (E/A-SBGS) from SBGS and examine their antitumor activities against human lung c
PMID 27618151

Consequences of a Chronic Exposure of Cultured Brain Astrocytes to the Anti-Retroviral Drug Efavirenz and its Primary Metabolite 8-Hydroxy Efavirenz.

Arend C1,2, Rother A2, Stolte S2,3, Dringen R4,5.
Neurochemical research.Neurochem Res.2016 Sep 21. [Epub ahead of print]
Efavirenz is a widely prescribed non-nucleoside reverse transcriptase inhibitor for the treatment of HIV infections. To test for potential long-term consequences of efavirenz on brain cells, cultured primary astrocytes were incubated with this substance or with its primary metabolite 8-hydroxy efavi
PMID 27655255

Japanese Journal

Styrene Altered Clock Gene Expression in Serum-Shocked Cultured Human Fibroblasts

MANZELLA Nicola,BRACCI Massimo,STAFFOLANI Sara [他],STRAFELLA Elisabetta,RAPISARDA Venerando,VALENTINO Matteo,AMATI Monica,COPERTARO Alfredo,SANTARELLI Lory
Bioscience, biotechnology, and biochemistry 77(6), 1296-1298, 2013-06-23
… A subtoxic dose of 100 µM of styrene altered the expression of clock genes BMAL1, PER2, PER3, CRY1, CRY2, and REV-ERB-α. …
NAID 10031184697

Toxicokinetics and Metabolism Deteriorated by Acute Nephrotoxicity after a Single Intravenous Injection of Hydrofluoric Acid in Rats

Mitsui Go,Dote Tomotaro,Yamadori Emi [他],IMANISHI Masafumi,NAKAYAMA Shin,OHNISHI Keiko,KONO Koichi
Journal of occupational health 52(6), 395-399, 2010-11-01
… Objectives: This study was designed to investigate the early dynamic state of hydrofluoric acid (HFA) in blood and urine as a model of accidental occupational exposure to a subtoxic dose of HFA. …
NAID 10026964769

Effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in rats

Adachi Kenji,Mizoguchi Keiji,Kawarada Shinya [他],MIYOSHI Akio,SUZUKI Masami,CHIBA Shuichi,DEKI Toshiaki
Journal of toxicological sciences 35(4), 503-514, 2010-08-01
… subtoxic dose) on the BLM (0.1 or 0.6 mg/rat)-induced lung injury of slight and moderate severity. …
NAID 10026566721