- 関
- subacute
WordNet
- less than acute; relating to a disease present in a person with no symptoms of it
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English Journal
- Multiple Sclerosis Disease Progression and Paradichlorobenzene: A Tale of Mothballs and Toilet Cleaner.
- Hession RM, Sharma V, Spiegel DE, Tat C, Hwang DG, Dieppa M, Mahdavi Z, Marder E, Stüve O.Author information Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas2Neurology Section, VA North Texas Health Care System, Medical Service, Dallas.AbstractIMPORTANCE Environmental factors are thought to be critical in the initiation and perpetuation of multiple sclerosis disease activity. OBSERVATIONS We describe the case of a woman in her late 30s with a diagnosis of relapsing-remitting multiple sclerosis, who continued to accumulate neurological disability despite long-term natalizumab treatment. The patient continued to have visual symptoms, left leg weakness, and gait instability. In addition, she subacutely developed an encephalopathy. Our investigations revealed that the patient had a long-standing history of chewing on toilet bowl deodorizing cakes. The main ingredient in this product is 99.9% paradichlorobenzene, which is also used in mothballs. CONCLUSIONS AND RELEVANCE This case illustrates that environmental causes for neurological deterioration should be investigated in patients with multiple sclerosis who display a rapidly progressive disease course and in whom potent pharmacotherapies fail. One possible cause is the ingestion of paradichlorobenzene-containing mothballs and toilet cleaners.
- JAMA neurology.JAMA Neurol.2013 Dec 16. doi: 10.1001/jamaneurol.2013.4395. [Epub ahead of print]
- IMPORTANCE Environmental factors are thought to be critical in the initiation and perpetuation of multiple sclerosis disease activity. OBSERVATIONS We describe the case of a woman in her late 30s with a diagnosis of relapsing-remitting multiple sclerosis, who continued to accumulate neurological dis
- PMID 24343157
- Hypoglycemic and antioxidant activities of the hydroethanolic leaf extract of Byrsocarpus coccineus Schumach. & Thonn. (Connaraceae).
- Dada OK1, Akindele AJ2, Morakinyo OA3, Sofidiya MO4, Ota D3.Author information 1Department of Pharmacology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, P. M. B. 12003 Lagos, Nigeria.2Department of Pharmacology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, P. M. B. 12003 Lagos, Nigeria. Electronic address: ajakindele@cmul.edu.ng.3Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, P. M. B. 12003 Lagos, Nigeria.4Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, P. M. B. 12003 Lagos, Nigeria.AbstractAIM: Diabetes Mellitus is associated with significant morbidity and mortality worldwide. The need for enhanced efficacy and safety, and cheaper and more readily available new drugs has increased the search for new antidiabetic drugs from plants. This study was conducted to investigate the antidiabetic activity of the hydroethanolic leaf extract of B. coccineus in rats.
- Chinese journal of natural medicines.Chin J Nat Med.2013 Nov;11(6):628-37. doi: 10.1016/S1875-5364(13)60073-4.
- AIM: Diabetes Mellitus is associated with significant morbidity and mortality worldwide. The need for enhanced efficacy and safety, and cheaper and more readily available new drugs has increased the search for new antidiabetic drugs from plants. This study was conducted to investigate the antidiabet
- PMID 24345504
- Oxidative stress precedes mitochondrial dysfunction in gerbil brain after aluminum ingestion.
- Vučetić-Arsić S, Radonjić NV, Jovanović M, Selaković V, Nikolić T, Velimirović M, Stojković T, Milovanović A, Milovanović J, Petronijević ND.Author information Special Hospital for Addictions, Teodora Drajzera 44, Belgrade, Serbia.AbstractSeveral studies suggest that aluminum (Al) intake might increase an individual's risk of developing Alzheimer disease. The dynamic of changes in acetylcholinesterase (AChE), cytochrome c oxidase (COX), Complex I, superoxide dismutase (SOD) and catalase (CAT) activities, and the lipid peroxide (MDA), superoxide anion (O2(-)) and thiol (SH) group levels in gerbil's brain after aluminum ingestion were analyzed. Gerbils that orally received aluminum chloride (LD25 or LD50) were sacrificed 2, 6 or 24h later. Another group was subacutely treated (21 days; LD10). Controls received saline. Biochemical parameters were measured in cortex, hippocampus, thalamus and nucleus caudatus. Two hours after acute Al exposure AChE activity and SH group content were decreased and MDA and O2(-) levels were elevated in all investigated brain structures. The changes of COX and CAT were structure specific. SOD was increased after 6h. Changes of investigated parameters were also seen after subacute Al treatment. These results might suggest the presence of additional source of free radicals in early phase of Al poisoning.
- Environmental toxicology and pharmacology.Environ Toxicol Pharmacol.2013 Nov;36(3):1242-52. doi: 10.1016/j.etap.2013.10.008. Epub 2013 Oct 23.
- Several studies suggest that aluminum (Al) intake might increase an individual's risk of developing Alzheimer disease. The dynamic of changes in acetylcholinesterase (AChE), cytochrome c oxidase (COX), Complex I, superoxide dismutase (SOD) and catalase (CAT) activities, and the lipid peroxide (MDA),
- PMID 24211763
Japanese Journal
- 下肢の異常感覚で発症したGerstmann-Sträussler-Scheinker病の1例
- 下肢の異常感覚で発症したGerstmann-Sträussler-Scheinker病の1例
- ステロイドパルス療法,血漿交換療法,免疫グロブリン静注療法に抵抗性で,長期ステロイド経口投与が有効であった橋本脳症の1例
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- adj. 1. Somewhat or moderately acute: subacute petals and sepals. 2. Between acute and chronic: subacute fever symptoms; subacute endocarditis. sub a·cute ly adv. subacute [ˌsʌbəˈkjuːt]. adj. intermediate between acute and chronic ...
- subacute /sub·acute/ (-ah-kūt´) somewhat acute; between acute and chronic. sub· a·cute (s b -ky t ). adj. Between acute and chronic. sub a·cute ly adv. Subacute. An abnormal condition present in a person who appears to be clinically well.
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