WordNet

any of several fat-soluble organic compounds having as a basis 17 carbon atoms in four rings; many have important physiological effects
an enzyme that catalyses the biochemical reduction of some specified substance

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Upreti R1, Hughes KA, Livingstone DE, Gray CD, Minns FC, Macfarlane DP, Marshall I, Stewart LH, Walker BR, Andrew R.
The Journal of clinical endocrinology and metabolism.J Clin Endocrinol Metab.2014 Aug;99(8):E1397-406. doi: 10.1210/jc.2014-1395. Epub 2014 May 13.
CONTEXT: 5α-Reductase (5αR) types 1 and 2 catalyze the A-ring reduction of steroids, including androgens and glucocorticoids. 5α-R inhibitors lower dihydrotestosterone in benign prostatic hyperplasia; finasteride inhibits 5αR2, and dutasteride inhibits both 5αR2 and 5αR1. In rodents, loss of 5
PMID 24823464

Longitudinal changes in glucocorticoid metabolism are associated with later development of adverse metabolic phenotype.

Crowley R1, Hughes BA2, Gray J3, McCarthy T4, Hughes S5, Shackleton C6, Crabtree N7, Nightingale P8, Stewart PM9, Tomlinson JW10.
European journal of endocrinology / European Federation of Endocrine Societies.Eur J Endocrinol.2014 Jul 1. pii: EJE-14-0256. [Epub ahead of print]
Objective: Dysregulation of enzymes that control local tissue steroid metabolism has been implicated in the pathogenesis of obesity and insulin resistance, however longitudinal changes in glucocorticoid metabolism have not been investigated. This study was performed to evaluate the role of glucocort
PMID 24986533

46,XY disorder of sexual development resulting from a novel monoallelic mutation (p.Ser31Phe) in the steroid 5α-reductase type-2 (SRD5A2) gene.

Chávez B1, Ramos L1, Gómez R2, Vilchis F1.
Molecular genetics & genomic medicine.Mol Genet Genomic Med.2014 Jul;2(4):292-6. doi: 10.1002/mgg3.76. Epub 2014 Mar 16.
Inactivating mutations of the 5α-steroid reductase type-2 (SRD5A2) gene result in a broad spectrum of masculinization defects, ranging from a male phenotype with hypospadias to a female phenotype with Wolffian structures. Molecular studies of the SRD5A2 revealed a new heterozygous gene variant with
PMID 25077171