関: steroid 17-alpha-hydroxylase

WordNet

any of several fat-soluble organic compounds having as a basis 17 carbon atoms in four rings; many have important physiological effects

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ステロイド(脂肪溶解性の有機化合物の総称)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/06/18 04:34:52」(JST)

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In enzymology, a steroid 17alpha-monooxygenase (EC 1.14.99.9) is an enzyme that catalyzes the chemical reaction

a steroid + AH₂ + O₂

\rightleftharpoons

a 17alpha-hydroxysteroid + A + H₂O

The 3 substrates of this enzyme are steroid, an electron acceptor AH₂, and O₂, whereas its 3 products are 17alpha-hydroxysteroid, the reduction product A, and H₂O.^[1]^[2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating). Other names in common use include steroid 17alpha-hydroxylase, cytochrome P-45017alpha, cytochrome P-450 (P-45017alpha,lyase), and 17alpha-hydroxylase-C17,20 lyase. This enzyme participates in c21-steroid hormone metabolism. It has 3 cofactors: NADH, NADPH, and Heme.

References

^ Lynn, W.S.; Brown, R.H. (1958). "The conversion of progesterone to androgens by testes". J. Biol. Chem. 232 (2): 1015–1030. PMID 13549484.
^ Yoshida, K.-I.; Oshima, H.; Troen, P. (1980). "Studies of the human testis. XIII. Properties of nicotinamide adenine dinucleotide (reduced form)-linked 17α-hydroxylation". J. Clin. Endocrinol. Metab. 50: 895–899. doi:10.1210/jcem-50-5-895. PMID 6966286.

External links

Steroid 17alpha-monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)

This EC 1.14 enzyme-related article is a stub. You can help Wikipedia by expanding it.

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1. まれな先天性副腎過形成 uncommon congenital adrenal hyperplasias
2. 副腎ステロイド生合成 adrenal steroid biosynthesis
3. 小児における原発性副腎不全の原因および臨床症状 causes and clinical manifestations of primary adrenal insufficiency in children
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5. 非定型生殖器（性分化疾患）を有する乳児の評価 evaluation of the infant with atypical genitalia disorder of sex development

English Journal

17α-HYDROXYLASE/17, 20-LYASE DEFICIENCY: CLINICAL AND MOLECULAR CHARACTERIZATION OF EIGHT CHINESE PATIENTS.

Wu C, Fan S, Qian Y, Zhou Y, Jin J, Dai Z, Jiang L.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.Endocr Pract.2017 May;23(5):576-582. doi: 10.4158/EP161610.OR. Epub 2017 Feb 22.
OBJECTIVE: 17α-hydroxylase/17, 20-lyase deficiency (17OHD) is caused by mutations in the cytochrome P450 17A1 (CYP17A1) gene. To better understand 17OHD, a rare disease, we described the clinical features and performed CYP17A1 gene analysis in 8 affected Chinese patients.METHODS: Patients with comp
PMID 28225307

[Androgen receptors in breast cancer: Expression, value and therapeutic prospects].

Héquet D1, Mzoughi S2, Rouzier R3, Guccione E2.
Bulletin du cancer.Bull Cancer.2017 Apr;104(4):363-369. doi: 10.1016/j.bulcan.2017.01.005. Epub 2017 Feb 16.
PMID 28216075

ACTH and Polymorphisms at Steroidogenic Loci as Determinants of Aldosterone Secretion and Blood Pressure.

MacKenzie SM1, Freel EM2, Connell JM3, Fraser R4, Davies E5.
International journal of molecular sciences.Int J Mol Sci.2017 Mar 7;18(3). pii: E579. doi: 10.3390/ijms18030579.
PMID 28272372

Japanese Journal

Profiles of Circulating Steroid Hormones, Gonadotropins, Immunoreactive Inhibin and Prolactin During Pregnancy in Goats and Immunolocalization of Inhibin Subunits, Steroidogenic Enzymes and Prolactin in the Corpus Luteum and Placenta

The Journal of reproduction and development 56(2), 243-250, 2010-04-01
NAID 10026324516

「ステロイド17α-水酸化酵素」

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steroid 17-alpha-monooxygenase
Identifiers
EC number	1.14.99.9
CAS number	9029-67-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
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PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
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NCBI	proteins

　　[★]

英: steroid 17alpha-hydroxylase, steroid 17α-hydroxylase
同: ステロイド17α水酸化酵素、ステロイド17αヒドロキシラーゼ、ステロイド17α-ヒドロキシラーゼ
関: 17α-水酸化酵素

「ステロイド17α水酸化酵素」

　　[★]

英: steroid 17alpha-hydroxylase
関: ステロイド17αヒドロキシラーゼ、ステロイド17α-ヒドロキシラーゼ、ステロイド17α-水酸化酵素、CYP17タンパク質

「ステロイド17αヒドロキシラーゼ」

　　[★]

英: steroid 17alpha-hydroxylase
関: ステロイド17α水酸化酵素、ステロイド17α-ヒドロキシラーゼ、ステロイド17α-水酸化酵素

「ステロイド17α-ヒドロキシラーゼ」

　　[★]

英: steroid 17alpha-hydroxylase
関: ステロイド17α水酸化酵素、ステロイド17αヒドロキシラーゼ、ステロイド17α-水酸化酵素

「CYP17」

　　[★]

CYP17タンパク質

関: steroid 17-alpha-hydroxylase

steroid 17alpha-hydroxylase

[1] Lynn, W.S.; Brown, R.H. (1958). "The conversion of progesterone to androgens by testes". J. Biol. Chem. 232 (2): 1015–1030. PMID 13549484.

[2] Yoshida, K.-I.; Oshima, H.; Troen, P. (1980). "Studies of the human testis. XIII. Properties of nicotinamide adenine dinucleotide (reduced form)-linked 17α-hydroxylation". J. Clin. Endocrinol. Metab. 50: 895–899. doi:10.1210/jcem-50-5-895. PMID 6966286.

v t e Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)
1.14.11: 2-oxoglutarate	Prolyl hydroxylase Lysyl hydroxylase
1.14.13: NADH or NADPH	Flavin-containing monooxygenase FMO1 FMO2 FMO3 FMO4 FMO5 Nitric oxide synthase NOS1 NOS2 NOS3 Cholesterol 7 alpha-hydroxylase Methane monooxygenase 3A4 Lanosterol 14 alpha-demethylase 24-hydroxycholesterol 7α-hydroxylase
1.14.14: reduced flavin or flavoprotein	19A1 2D6 2E1
1.14.15: reduced iron-sulfur protein	11B1 11B2 11A1
1.14.16: reduced pteridine (BH4 dependent)	Phenylalanine hydroxylase Tyrosine hydroxylase Tryptophan hydroxylase
1.14.17: reduced ascorbate	Dopamine beta-hydroxylase
1.14.18-19: other	Tyrosinase Stearoyl-CoA desaturase-1
1.14.99 - miscellaneous	Cyclooxygenase Heme oxygenase (HMOX1) Squalene monooxygenase 17A1 21A2

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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steroid 17alpha-hydroxylase