English Journal

Through-space transfer of chiral information mediated by a plasmonic nanomaterial.

Ostovar Pour S1, Rocks L2, Faulds K2, Graham D2, Parchaňský V3, Bouř P3, Blanch EW4.
Nature chemistry.Nat Chem.2015 Jul;7(7):591-6. doi: 10.1038/nchem.2280. Epub 2015 Jun 15.
The ability to detect chirality gives stereochemically attuned nanosensors the potential to revolutionize the study of biomolecular processes. Such devices may structurally characterize the mechanisms of protein-ligand binding, the intermediates of amyloidogenic diseases and the effects of phosphory
PMID 26100808

Computational Refinement and Validation Protocol for Proteins with Large Variable Regions Applied to Model HIV Env Spike in CD4 and 17b Bound State.

Rasheed M1, Bettadapura R1, Bajaj C2.
Structure (London, England : 1993).Structure.2015 Jun 2;23(6):1138-49. doi: 10.1016/j.str.2015.03.026.
Envelope glycoprotein gp120 of HIV-1 possesses several variable regions; their precise structure has been difficult to establish. We report a new model of gp120, in complex with antibodies CD4 and 17b, complete with its variable regions. The model was produced by a computational protocol that uses
PMID 26039348

Highly Stereoselective [4+2] and [3+2] Spiroannulations of 2-(2-Oxoindolin-3-ylidene)acetic Esters Catalyzed by Bifunctional Thioureas.

Monari M1, Montroni E1, Nitti A1, Lombardo M1, Trombini C1, Quintavalla A2.
Chemistry (Weinheim an der Bergstrasse, Germany).Chemistry.2015 Jun 1. doi: 10.1002/chem.201500676. [Epub ahead of print]
A new Michael-Michael cascade reaction between 2-(2-oxoindolin-3-ylidene)acetic esters 1 and nitroenoates 2, catalyzed by bifunctional thioureas, is investigated. The combination of the two Michael reactions results in a novel and facile [4+2] or [3+2] spiroannulation process, which is characterized
PMID 26032428