WordNet
- an abnormal spherical red blood cell
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/05/15 00:15:02」(JST)
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Spherocytosis seen in a peripheral blood smear from a patient with hereditary spherocytosis
Spherocytosis is an auto-hemolytic anemia (a disease of the blood) characterized by the production of red blood cells (RBCs), or erythrocytes, that are sphere-shaped, rather than bi-concave disk shaped. Spherocytes are found in hereditary spherocytosis and autoimmune hemolytic anemia.[1]
It almost always refers to hereditary spherocytosis. This is caused by a molecular defect in one or more of the proteins of the red blood cell cytoskeleton, including, spectrin, ankyrin, Band 3, or Protein 4.2. Because the cell skeleton has a defect, the blood cell contracts to its most surface-tension efficient and least flexible configuration, a sphere. The sphere-shaped red blood cells are known as spherocytes. Though the spherocytes have a smaller surface area through which oxygen and carbon dioxide can be exchanged, they in themselves perform adequately to maintain healthy oxygen supplies. However, they have a high osmotic fragility--when placed into water, they are more likely to burst than normal red blood cells. These cells are more prone to physical degradation.
They are most commonly found in immunologically-mediated hemolytic anemias and in hereditary spherocytosis, but the former would have a positive direct Coombs test and the latter would not. The misshapen but otherwise healthy red blood cells are mistaken by the spleen for old or damaged red blood cells and it thus constantly breaks them down, causing a cycle whereby the body destroys its own blood supply (auto-hemolysis).
The term "non hereditary spherocytosis" is occasionally used, albeit rarely. [2]
See also [edit]
- Anemia
- Blood
- Blood diseases
- Red blood cells
- Hereditary diseases
External links [edit]
- A short article from WebMD
- A picture of spherocytes from Medline
- Hereditary Spherocytosis from Medscape
References [edit]
- ^ Robert S. Hillman; Kenneth A. Ault; Henry M. Rinder (2005). Hematology in clinical practice: a guide to diagnosis and management. McGraw-Hill Professional. pp. 146–. ISBN 978-0-07-144035-6. Retrieved 15 November 2010.
- ^ Thoma J, Kutter D, Casel S, et al. (2005). "HbSC hemoglobinopathy suspected by chest x-ray and red blood cell morphology". Acta Clin Belg 60 (6): 377–82. PMID 16502600.
Abnormal clinical and laboratory findings for blood tests (R70–R79, 790)
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Red blood cells |
Size
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- Anisocytosis
- Macrocyte
- Microcyte
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Shape
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- membrane abnormalities: Acanthocyte
- Codocyte
- Ovalocyte
- Spherocyte
- other: Dacrocyte
- Echinocyte
- Schistocyte
- Degmacyte
- Drepanocyte
- Stomatocyte
- Knizocyte
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Hemoglobinization
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Inclusion bodies
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- developmental organelles (Howell-Jolly body, Basophilic stippling, Pappenheimer bodies, Cabot rings)
- abnormal hemoglobin precipitation (Heinz body)
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Other
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- Rouleaux
- Reticulocyte
- Elevated ESR
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Lymphocytes |
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Small molecules |
Blood sugar
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- Hypoglycemia
- Hyperglycemia
- Prediabetes (Impaired fasting glucose, Impaired glucose tolerance)
- Oxyhyperglycemia
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Nitrogenous
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- Azotemia
- Hyperuricemia
- Hypouricemia
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Proteins |
LFT
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- Elevated transaminases
- Elevated ALP
- Hypoproteinemia (Hypoalbuminemia)
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Other
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- Elevated cardiac markers
- Elevated alpha-fetoprotein
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Minerals |
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Pathogens/sepsis |
- Bacteremia
- Viremia
- Fungemia
- Parasitemia
- Algaemia
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cell/phys (coag, heme, immu, gran), csfs
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rbmg/mogr/tumr/hist, sysi/epon, btst
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drug (B1/2/3+5+6), btst, trns
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noco/acba/cong/tumr, sysi/epon, urte
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proc/itvp, drug (G4B), blte, urte
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UpToDate Contents
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English Journal
- Screening and confirmation of hereditary spherocytosis in children using a CELL-DYN Sapphire haematology analyser.
- Rooney S1, Hoffmann JJ, Cormack OM, McMahon C.
- International journal of laboratory hematology.Int J Lab Hematol.2014 Apr 17. doi: 10.1111/ijlh.12245. [Epub ahead of print]
- INTRODUCTION: Multidimensional optical scatter of sphered erythrocytes can identify and enumerate hyperchromic erythrocytes, which might be used for hereditary spherocytosis (HS) screening. The flow cytometric eosin-5'-maleimide test (EMA) is highly sensitive and specific for HS as a confirmatory me
- PMID 24739214
- Gas-forming liver abscess associated with rapid hemolysis in a diabetic patient.
- Kurasawa M, Nishikido T, Koike J, Tominaga S, Tamemoto H.
- World journal of diabetes.World J Diabetes.2014 Apr 15;5(2):224-9. doi: 10.4239/wjd.v5.i2.224.
- We experienced a case of liver abscess due to Clostridium perfringens (CP) complicated with massive hemolysis and rapid death in an adequately controlled type 2 diabetic patient. The patient died 6 h after his first visit to the hospital. CP was later detected in a blood culture. We searched for cas
- PMID 24748935
- Critical values in Hematology.
- McFarlane A1, Aslan B, Raby A, Bourner G, Padmore R.
- International journal of laboratory hematology.Int J Lab Hematol.2014 Apr 2. doi: 10.1111/ijlh.12226. [Epub ahead of print]
- INTRODUCTION: Critical values are life-threatening results that require immediate notification to the patient's healthcare provider. Accreditation bodies require laboratories to establish critical values. A survey of Ontario laboratories was conducted to determine current practice for critical value
- PMID 24690478
Japanese Journal
- Finite Element Method Analysis of the Deformation of Human Red Blood Cells(<Special Issue>Macro-, Micro-, Meso-, and Nano-scopic Strength of Materials Relating to Microstructures)
- Higuchi Rie,Kanno Yoshinori
- JSME international journal. Series A, Solid mechanics and material engineering 49(3), 331-336, 2006-07-15
- … An erythrocyte and a spherocyte are subjected to aspiration pressure with a micropipette and analyzed by the finite element method (FEM). … The comparison of the erythrocyte and the spherocyte indicates that the y-direction displacement of the erythrocyte was larger than that of the spherocyte under the same aspiration pressure. …
- NAID 110004798967
- 922 粒子法を用いた3次元流路を流れる赤血球の変形シミュレーション(OS-9E,OS-9 メッシュフリー/粒子法)
- 飯野 正昭,奥田 雄一
- 日本バイオレオロジー学会誌(B&R) = Journal of Japanese Society of Biorheology 13(2), 94-97, 1999-06-30
- … ESR of spherocyte in plasma solution was significantly greater than that in saline solution. …
- NAID 10002622343
Related Links
- Spherocyte definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now! Thesaurus Translator Reference Word of the Day Blog Slideshows Apps by Dictionary My Account ...
- spherocyte /sphe·ro·cyte/ (sfēr´o-sīt) a small, globular, completely hemoglobinated erythrocyte without the usual central pallor characteristically found in hereditary spherocytosis but also in acquired hemolytic anemia.spherocyt´ic ...
Related Pictures
![Spherocyte](https://1mg.info/0/6/f/1721.jpg)
![Sphérocytes (spherocyte)](https://1mg.info/0/6/f/1722.jpg)
![Spherocytes](https://1mg.info/0/6/f/1723.jpg)
![Spherocyte : 1000X](https://1mg.info/0/6/f/1724.jpg)
![image spherocyte for term side of card](https://1mg.info/0/6/f/1725.jpg)
★リンクテーブル★
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- 英
- spherocyte
- 関
- 赤血球