English Journal

Integration of target responsive hydrogel with cascaded enzymatic reactions and microfluidic paper-based analytic devices (µPADs) for point-of-care testing (POCT).

Tian T1, Wei X2, Jia S1, Zhang R1, Li J1, Zhu Z3, Zhang H1, Ma Y1, Lin Z2, Yang CJ4.
Biosensors & bioelectronics.Biosens Bioelectron.2016 Mar 15;77:537-42. doi: 10.1016/j.bios.2015.09.049. Epub 2015 Sep 30.
Paper based microfluidics (µPADs) with advantages of portability, low cost, and ease of use have attracted extensive attention. Here we describe a novel method that integrates glucoamylase-trapped aptamer-crosslinked hydrogel for molecular recognition with cascaded enzymatic reactions for signal am
PMID 26474094

A label-free fluorescence strategy for selective detection of nicotinamide adenine dinucleotide based on a dumbbell-like probe with low background noise.

Chen X1, Lin C2, Chen Y1, Wang Y3, Chen X4.
Biosensors & bioelectronics.Biosens Bioelectron.2016 Mar 15;77:486-90. doi: 10.1016/j.bios.2015.10.005. Epub 2015 Oct 9.
In this work we developed a novel label-free fluorescence sensing approach for the detection of nicotinamide adenine dinucleotide (NAD(+)) based on a dumbbell-like DNA probe designed for both ligation reaction and digestion reaction with low background noise. SYBR Green I (SG I), a double-helix dye,
PMID 26454831

Distance-based microfluidic quantitative detection methods for point-of-care testing.

Tian T1, Li J1, Song Y1, Zhou L1, Zhu Z1, Yang CJ1.
Lab on a chip.Lab Chip.2016 Mar 1. [Epub ahead of print]
Equipment-free devices with quantitative readout are of great significance to point-of-care testing (POCT), which provides real-time readout to users and is especially important in low-resource settings. Among various equipment-free approaches, distance-based visual quantitative detection methods re
PMID 26928571