WordNet

a colloid that has a continuous liquid phase in which a solid is suspended in a liquid (同)colloidal_solution, colloidal suspension
the syllable naming the fifth (dominant) note of any musical scale in solmization (同)soh, so
relating to or derived from the sun or utilizing the energies of the sun; "solar eclipse"; "solar energy"
breakdown of elastic tissue (as the loss of elasticity in the skin of elderly people that results from degeneration of connective tissue)

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ソ(全音階の第5音)
ソル(ペルーの貨幣単位で青銅貨)
『太陽の』,太陽からの;太陽の作用による

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/09/29 22:52:26」(JST)

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Actinic, or solar, elastosis is an accumulation of abnormal elastin (elastic tissue) in the dermis of the skin,^[1] and in the conjunctiva of the eye,^[2] which occurs as a result of the cumulative effects of prolonged and excessive sun exposure, a process known as photoaging.

Clinical features

Actinic elastosis usually appears as thickened, dry, wrinkled skin. Several clinical variants have been recorded. One of the most readily identifiable is the thickened, deeply fissured skin seen on the back of the chronically sun-exposed neck, known as cutis rhomboidalis nuchae.^[1] These features are a part of the constellation of changes that are seen in photoaged skin.^[1]

Causes / Aetiology

The origin of the elastotic material in the dermis remains a subject of debate. Theories on the formation of the elastotic material include actinic stimulation of fibroblasts, promoting synthesis of this material; or that the material is a degradation product of collagen, elastin or both.^[1]

Histopathology

In the earlier stages of actinic elastosis, elastic fiber proliferation can be seen in the dermis. As the condition becomes more established, the collagen fibers of the papillary dermis and reticular dermis become increasingly replaced by thickened and curled fibers that form tangled masses and appear basophilic under routine haematoxylin and eosin staining. These fibers stain black with the Verhoeff stain.^[1]

Treatment

There are numerous treatment options for photoaged skin. These include dermabrasion, topical application of retinoic acid, carbon dioxide laser resurfacing, hyaluronic acid injection into the dermis, Imiquimod, tacrolimus ointment and topical oestrogen therapy. These treatments have variable efficacy.^[1]

The most effective prevention strategy for photoaging remains minimization of sun-exposure through use of sunscreen and other sun exposure avoidance measures.^[1]

References

^ ^a ^b ^c ^d ^e ^f ^g Weedon, David (2010). Weedon's Skin Pathology, 3rd Edition. Elsevier. ISBN 978-0-7020-3485-5.
^ Klintworth, G; Cummings, T. "24; The eye and ocular adnexa". In Stacey, Mills. Sternberg's Diagnostic Surgical Pathology (5 ed.). ISBN 978-0-7817-7942-5.

UpToDate Contents

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1. 光による老化 photoaging
2. 悪性黒子：臨床症状、診断、およびマネージメント lentigo maligna clinical manifestations diagnosis and management
3. 日光角化症の疫学、自然経過、および診断 epidemiology natural history and diagnosis of actinic keratosis
4. 顔面病変のダーモスコピー dermoscopy of facial lesions
5. 酒さ：病因、臨床的特徴、および診断 rosacea pathogenesis clinical features and diagnosis

English Journal

Clinical and histopathologic study of benign lichenoid keratosis on the face.

Kim HS, Park EJ, Kwon IH, Kim KH, Kim KJ.Source*Department of Dermatology, College of Medicine, Hallym University, Anyang, Korea †Department of Dermatology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.
The American Journal of dermatopathology.Am J Dermatopathol.2013 Oct;35(7):738-41. doi: 10.1097/DAD.0b013e318281cd37.
Benign lichenoid keratosis is a cutaneous entity that consists of a nonpruritic papule or slightly indurated plaque that is histologically characterized by a band-like inflammatory infiltrate with interface involvement. The purpose of this study was to investigate the clinical and histopathologic fe
PMID 23860115

A quantitative approach to histopathological dissection of elastin-related disorders using multiphoton microscopy.

Tong PL, Qin J, Cooper CL, Lowe PM, Murrell DF, Kossard S, Ng LG, Roediger B, Weninger W, Haass NK.SourceCentenary Institute, Newtown, NSW, Australia; Discipline of Dermatology, University of Sydney, Camperdown, NSW, Australia; Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
The British journal of dermatology.Br J Dermatol.2013 Oct;169(4):869-79. doi: 10.1111/bjd.12430.
BACKGROUND: Multiphoton microscopy (MPM) is a novel imaging technology that has recently become applicable for diagnostic purposes. The use of (near) infrared light in MPM allows for deep tissue imaging. In addition, this modality exploits the autofluorescent nature of extracellular matrix fibres wi
PMID 23662922

Follicular Mucinosis Associated With Nonlymphoid Skin Conditions.

Mir-Bonafé JM, Cañueto J, Fernández-López E, Santos-Briz A.SourceDepartments of *Dermatology, and †Pathology, University Hospital of Salamanca, Paseo de San Vicente, Salamanca, Spain.
The American Journal of dermatopathology.Am J Dermatopathol.2013 Sep 20. [Epub ahead of print]
BACKGROUND:: Follicular mucinosis coexisting with lymphoproliferative disorders has been thoroughly debated. However, it has been rarely reported in association with inflammatory disorders.METHODS:: Thirteen cases have been retrieved, and those with cutaneous lymphoma or alopecia mucinosa were exclu
PMID 24061405

Japanese Journal

真皮の光老化の分子メカニズム (AYUMI 光老化の臨床とメカニズム)

清水忠道
医学のあゆみ 248(8), 587-591, 2014-02-22
NAID 40019985607

熱傷瘢痕上に生じた異型線維黄色腫

池田真希,中原真希子,内博史 [他],古江増隆
西日本皮膚科 76(6), 562-564, 2014
… また病変部近傍の真皮浅層に solar elastosis，基底層の極性の乱れがあり，日光角化症も合併していた。 …
NAID 130005065013

悪性線維性組織球腫の1例

水野尚,種子島智彦,鈴木亜希,久世清佳
Skin Cancer 28(3), 320-324, 2014
… 全摘生検では表皮直下からほぼ真皮内に限局する境界明瞭な病変であり，grenz zoneやepidermal collaretteはみられず，病変周囲の真皮にsolar elastosisもなかった。 …
NAID 130004697525