シンドビス熱
WordNet
- a rise in the temperature of the body; frequently a symptom of infection (同)febrility, febricity, pyrexia, feverishness
- intense nervous anticipation; "in a fever of resentment"
- highly excited; "a fevered imagination"
PrepTutorEJDIC
- 〈U〉《しばしばa fever》(身体の異常な)『熱』,発熱 / 〈U〉『熱病』 / 〈U〉〈C〉(…に対する)『興奮』,熱狂《+『for』+『名』》
- (比較変化なし)《名詞の前にのみ用いて》熱のある,熱病にかかった / 熱にうかされたような,興奮した / (憎しみなどが)異常に強い
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/21 22:28:21」(JST)
[Wiki en表示]
| Sindbis virus |
|
| CryoEM model of Sindbis virus. EMDB entry EMD-2374[1] |
| Virus classification |
| Group: |
Group IV ((+)ssRNA) |
| Family: |
Togaviridae |
| Genus: |
Alphavirus |
| Species: |
Sindbis virus |
Sindbis Virus (SINV) is a member of the Togaviridae family, in the alphavirus subfamily. The virus was first isolated in 1952 in Cairo, Egypt. The virus is transmitted by mosquitoes (Culex spp.) SINV causes sindbis fever in humans and the symptoms include arthralgia, rash and malaise. Sindbis fever is most common in South and East Africa, Egypt, Israel, Philippines and parts of Australia. Sindbis virus is an "arbovirus" (arthropod-borne) and is maintained in nature by transmission between vertebrate (bird) hosts and invertebrate (mosquito) vectors. Humans are infected with Sindbis virus when bitten by an infected mosquito. SINV has been linked to Pogosta disease in Finland,[2] Ockelbo disease in Sweden and Karelian fever in Russia.
Contents
- 1 Virus structure, genome and replication
- 2 See also
- 3 References
- 4 External links
Virus structure, genome and replication
Sindbis viruses are enveloped particles with an icosahedral capsid. Its genome is a single stranded RNA approximately 11.7kb long. It has a 5' cap and 3' polyadenylated tail therefore serves directly as messenger RNA (mRNA) in a host cell. The genome encodes four non-structural proteins at the 5' end and the capsid and two envelope proteins at the 3' end. This is characteristic of all Togaviruses. Replication is cytoplasmic and rapid. The genomic RNA is partially translated at the 5’ end to produce the non-structural proteins which are then involved in genome replication and the production of new genomic RNA and a shorter sub-genomic RNA strand. This sub-genomic strand is translated into the structural proteins. The viruses assemble at the host cell surfaces and acquire their envelope through budding.
A non-coding RNA element has been found to be essential for Sindbis virus genome replication.[3]
See also
References
- MicrobiologyBytes: Togaviruses
- CDC: Pogosta disease and Sindbis virus
- Sindbis virus - ICTVdB - The Universal Virus Database, version 4.
- ^ Cao, S.; Zhang, W. (2013). "Characterization of an early-stage fusion intermediate of Sindbis virus using cryoelectron microscopy". Proceedings of the National Academy of Sciences 110 (33): 13362–13367. doi:10.1073/pnas.1301911110. PMC 3746934. PMID 23898184.
- ^ Kurkela S, Manni T, Vaheri A, Vapalahti O. Causative agent of Pogosta disease isolated from blood and skin lesions, Emerg Infect Dis [serial on the Internet]. Published 2004 May. (accessed 2007-10-16)
- ^ Frolov, I; Hardy R; Rice CM (2001). "Cis-acting RNA elements at the 5' end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis". RNA 7 (11): 1638–1651. doi:10.1017/S135583820101010X. PMC 1370205. PMID 11720292.
External links
- Virus Pathogen Database and Analysis Resource (ViPR): Togaviridae
|
Zoonotic viral diseases (A80–B34, 042–079)
|
|
| Arthropod-borne |
| Mosquito-borne |
| Bunyaviridae |
- Arbovirus encephalitides: La Crosse encephalitis
- Batai virus (BATV)
- Bwamba Fever (BWAV)
- California encephalitis
- Jamestown Canyon virus
- Tete virus
- Tahyna virus (TAHV)
- Viral hemorrhagic fevers: Rift Valley fever
- Bunyamwera fever (BUNV)
- Ngari virus (NRIV)
|
|
| Flaviviridae |
- Arbovirus encephalitides: Japanese encephalitis
- Australian encephalitis
- Saint Louis encephalitis
- West Nile fever
- Viral hemorrhagic fevers: Dengue fever
- Yellow fever
- Zika fever
|
|
| Togaviridae |
- Arbovirus encephalitides: Eastern equine encephalomyelitis
- Western equine encephalomyelitis
- Venezuelan equine encephalomyelitis
- Chikungunya
- O'Nyong-nyong fever
- Ross River fever
- Semliki Forest virus
- Sindbis fever
|
|
| Reoviridae |
|
|
|
| Tick-borne |
| Bunyaviridae |
- Viral hemorrhagic fevers: Crimean–Congo hemorrhagic fever
- Heartland virus
- Bhanja virus
- Sandfly fever Naples virus
- Lone Star virus
- Tete virus
|
|
| Flaviviridae |
- Arbovirus encephalitides: Tick-borne encephalitis
- Powassan encephalitis
- Viral hemorrhagic fevers: Omsk hemorrhagic fever
- Kyasanur forest disease
- Langat virus (LGTV)
|
|
| Reoviridae |
- Colorado tick fever
- Kemerovo tickborne viral fever
|
|
|
| Sandfly-borne |
| Bunyaviridae |
- Adria virus (ADRV)
- Pappataci fever
- Sandfly fever Naples virus
- Oropouche fever
- SFTS virus
|
|
| Rhabdoviridae |
|
|
|
|
| Mammal-borne |
| Rodent-borne |
| Arenaviridae |
- Viral hemorrhagic fevers: Lassa fever
- Venezuelan hemorrhagic fever
- Argentine hemorrhagic fever
- Brazilian hemorrhagic fever
- Bolivian hemorrhagic fever
- LUJV
- CHPV
|
|
| Bunyaviridae |
- Hemorrhagic fever with renal syndrome
- Hantavirus pulmonary syndrome
|
|
|
| Bat-borne |
| Filoviridae |
- Viral hemorrhagic fevers: Ebola virus disease
- BDBV
- EBOV
- SUDV
- TAFV
- Marburg virus disease
- MARV
- RAVV
|
|
| Rhabdoviridae |
|
|
| Paramyxoviridae |
|
|
|
| Primate-borne |
| Herpesviridae |
|
|
| Retroviridae |
- Simian foamy virus
- HTLV-1
- HTLV-2
|
|
| Poxviridae |
- Tanapox
- Yaba monkey tumor virus
|
|
|
| Multiple vectors |
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Sindbis virus as a human pathogen-epidemiology, clinical picture and pathogenesis.
- Adouchief S1, Smura T1, Sane J2, Vapalahti O1,3,4, Kurkela S1,3.
- Reviews in medical virology.Rev Med Virol.2016 Mar 15. doi: 10.1002/rmv.1876. [Epub ahead of print]
- Sindbis virus (SINV; family Togaviridae, genus Alphavirus) is an enveloped RNA virus widely distributed in Eurasia, Africa, Oceania and Australia. SINV is transmitted among its natural bird hosts via mosquitoes. Human disease caused by SINV infection has been reported mainly in South Africa and in N
- PMID 26990827
- Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses.
- Varghese FS1, Kaukinen P1, Gläsker S2, Bespalov M3, Hanski L4, Wennerberg K3, Kümmerer BM2, Ahola T5.
- Antiviral research.Antiviral Res.2016 Feb;126:117-24. doi: 10.1016/j.antiviral.2015.12.012. Epub 2016 Jan 2.
- Chikungunya virus (CHIKV) is an arthritogenic arbovirus of the Alphavirus genus, which has infected millions of people after its re-emergence in the last decade. In this study, a BHK cell line containing a stable CHIKV replicon with a luciferase reporter was used in a high-throughput platform to scr
- PMID 26752081
- Trisubstituted Thieno[3,2-b]pyrrole 5-Carboxamides as Potent Inhibitors of Alphaviruses.
- Ching KC1,2, Kam YW3, Merits A4, Ng LF3,5, Chai CL1,2,6.
- Journal of medicinal chemistry.J Med Chem.2015 Dec 10;58(23):9196-213. doi: 10.1021/acs.jmedchem.5b01047. Epub 2015 Nov 19.
- Chikungunya virus (CHIKV) is a re-emerging vector-borne alphavirus and is transmitted to humans by Aedes mosquitoes. Despite the re-emergence of CHIKV as an epidemic threat, there is no approved effective antiviral treatment currently available for CHIKV. Herein, we report the synthesis and structur
- PMID 26540338
Japanese Journal
- ゲタウイルスを用いたヒトインターフェロン測定の試み
Related Links
- Sind·bis fever (sĭnd′bĭs) n. A febrile illness of humans in Africa, Australia, and other countries, characterized by arthralgia, rash, and malaise. It is caused by the Sindbis virus and transmitted by culicine mosquitoes. Sind·bis fe·ver a ...
- Sindbis fever Sind·bis fever (sĭnd'bĭs) n. A febrile illness of humans in Africa, Australia, and other countries, characterized by arthralgia, rash, and malaise. It is caused by the Sindbis virus and transmitted by culicine mosquitoes.