- 同
- Gas-X, Mylicon
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/21 03:55:54」(JST)
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Simethicone
|
Systematic (IUPAC) name |
Poly(dimethylsiloxane), silicon dioxide
|
Clinical data |
AHFS/Drugs.com |
monograph |
Pregnancy
category |
|
Legal status |
|
Routes of
administration |
Oral |
Pharmacokinetic data |
Bioavailability |
not absorbed from the gut |
Protein binding |
N/A |
Metabolism |
N/A |
Biological half-life |
N/A |
Excretion |
N/A |
Identifiers |
CAS Registry Number |
8050-81-5 Y |
ATC code |
A03AX13 |
PubChem |
CID: 6433516 |
ChEMBL |
CHEMBL1200838 N |
Chemical data |
Formula |
(C2H6OSi)n · (SiO2)m |
Molecular mass |
variable |
N (what is this?) (verify) |
Simethicone is an orally administered anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas — mainly swallowed air, with small amounts of hydrogen and methane[1][2]— in the stomach or intestines. Simethicone is a mixture of polydimethylsiloxane and hydrated silica gel.
Contents
- 1 Chemical action and pharmaceutical effects
- 2 Availability
- 3 Side effects
- 4 References
- 5 External links
Chemical action and pharmaceutical effects
Simethicone is an anti-foaming agent that decreases the surface tension of gas bubbles, causing them to combine into larger bubbles in the stomach that can be passed more easily. Simethicone does not reduce or prevent the formation of gas in the digestive tract, rather, it increases the rate at which it exits the body.[3] However, simethicone can relieve pain caused by gas in the intestines by decreasing foaming, which then allows for easier passing of flatulence.
Simethicone is not absorbed by the body into the bloodstream, and is therefore considered relatively safe. National Institutes of Health (NIH)[4] reports there are usually no side effects when simethicone is taken as directed. Although simethicone has also been promoted as a treatment for colic in babies, randomised controlled trials have not demonstrated efficacy for this use; despite traditional views on the subject, colic does not appear to be caused by gas.[5][6]
Availability
Simethicone is generally available over the counter under many brand names in varying dosage sizes and combinations with other drugs, including:
- Aero-Red (Spain)
- Air-X (Thailand)
- Anaflat (Teva)
- Antacil (Thailand)
- Antiflat[7][8] (Austria)
- Baby's Own Infant Drops
- Bearse (Korea)
- Bloateze (Phoenix Labs - Ireland)
- Deflatine
- De-Gas (Jordan,Thailand, Australia)
- Di-gel (di-gel Health Products, LLC - USA)
- Disflatyl (Egypt)
- Dulcogas (Turkey, Australia)
- Espumisan (Bulgaria, Hungary, Romania, Poland, Czech Republic, Slovakia, Croatia, Russia, Macedonia)
- Flatin (HU)
- Flatulex
- Factor AG 200 (Argentina)
- GasAid
- Gascon (Taiwan)
- Gas-Med
- Gas Relief
- Gasvan (Serbia)
- Gas-X
- Gazim X (Israel)
- Gaszym (Thailand)
- Genasyme
- Imodium Multi-Symptom Relief (formerly Imodium Advanced)
- Imogas
- Imonogas
- Infacol
- Infacon
- Kremil-S
- Kupla Stop (Finland)
|
- Lefax (Germany)
- Little Tummys
- Luftal (Brazil and Mexico)
- Maalox Anti-Gas
- Maalox Max
- Mag77
- Meteoxane (France)
- Metsil (Turkey)
- Minicol (Pakistan)
- Minifom (Norway, Sweden)
- My Baby Gas Relief Drops
- Mylanta Gas
- Mylanta Gas Relief
- Mylicon Drops
- Mylicongas (Italy)
- Ovol
- Phazyme
- Rantac-MPS(UNIQUE PHARMA, India)
- Refalgin (IT)
- Rennie Deflatine
- Rolaids
- SAB Simplex
- Silan (Uruguay)
- Siloxogene (India)
- Simeco (Philippines)
- Simicol (Israel)
- Telament (South Africa)
- Triaerom (Peru)
- WindEze (UK)
|
Side effects
The most common adverse effects of simethicone are gastrointestinal symptoms, including mild diarrhea, nausea, regurgitation, and vomiting.[9]
References
- ^ http://www.hopkinsmedicine.org/healthlibrary/conditions/digestive_disorders/gas_in_the_digestive_tract_85,P00369/
- ^ http://www.badgut.org/information-centre/intestinal-gas.html
- ^ Norton, William (2005-01-09). "Controlling Intestinal Gas". Retrieved 2007-07-31.
- ^ PubMed Health, produced by National Center for Biotechnology, a division of the National Library of Medicine at the National Institutes of Health; see http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000747/
- ^ University of Michigan clinical trial for simethicone used for colic
- ^ Patient.info on colic
- ^ Product information (German)
- ^ Product information (German)
- ^ from Micromedex Dug Information. Retrieved 2013-01-13.
External links
- "Jackson Gastroenterology - Patient Education - Simethicone". Retrieved Nov 11, 2013.
- "Medline Plus - Simethicone". Archived from the original on February 19, 2007. Retrieved Nov 11, 2013.
Drugs for functional gastrointestinal disorders (A03)
|
|
Drugs for
functional
bowel disorders |
Antimuscarinics
|
Tertiary
amino group
|
- Oxyphencyclimine
- Camylofin
- Mebeverine
- Trimebutine
- Rociverine
- Dicycloverine
- Dihexyverine
- Difemerine
- Piperidolate
|
|
Quaternary
ammonium
compounds
|
- Benzilone
- Mepenzolate
- Pipenzolate
- Glycopyrronium
- Oxyphenonium
- Penthienate
- Methantheline
- Propantheline
- Otilonium
- Tridihexethyl
- Isopropamide
- Hexocyclium
- Poldine
- Bevonium
- Diphemanil
- Tiemonium
- Prifinium
- Timepidium
- Fenpiverinium
|
|
|
Phosphodiesterase
inhibitors
|
- Papaverine
- Drotaverine
- Moxaverine
|
|
Acting on
serotonin receptors
|
- 5-HT3 antagonists
- 5-HT4 agonists
- Mosapride
- Prucalopride
- Tegaserod
|
|
Other
|
- Alverine
- Caroverine
- Chlorbenzoxamine
- Diisopromine
- Dimethylaminopropionylphenothiazine
- Fenpiprane
- Fenoverine
- Idanpramine
- Isometheptene
- Phloroglucinol
- Pinaverium
- Proxazole
- Silicones
- Tiropramide
- Trepibutone
- Trimethyldiphenylpropylamine
|
|
|
Belladonna
and derivatives
(antimuscarinics) |
- tertiary amines: Atropine
- Hyoscyamine
- quaternary ammonium compounds:
- Scopolamine
- Butylscopolamine
- Methylscopolamine
- Methylatropine
- Fentonium
- Cimetropium bromide
|
|
Propulsives |
- primarily dopamine antagonists
- Metoclopramide/Bromopride
- Clebopride
- Domperidone
- Alizapride
- 5-HT4 agonists
|
|
Index of digestion
|
|
Description |
- Anatomy
- Physiology
- Development
|
|
Disease |
- Congenital
- Neoplasms and cancer
- Inflammatory bowel disease
- Gluten sensitivity
- Other
- Symptoms and signs
- Blood tests
|
|
Treatment |
- Procedures
- Drugs
- anabolic steroids
- antacids
- diarrhoea and infection
- bile and liver
- functional gastrointestinal disorders
- laxatives
- peptic ulcer and reflux
- nausea and vomiting
- other
- Surgery
|
|
|
UpToDate Contents
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English Journal
- Development of an UPLC-MS/MS micromethod for quantitation of cinitapride in plasma and its application in a pharmacokinetic interaction trial.
- Marcelín-Jiménez G1, Contreras L2, Esquivel J2, Ávila Ó3, Batista D2, Ángeles AP1, García-González A1.
- Bioanalysis.Bioanalysis.2017 Mar;9(6):569-579. doi: 10.4155/bio-2016-0210. Epub 2017 Feb 22.
- AIM: Cinitapride (CIN) is a benzamide-derived molecule used for the treatment of gastroesophageal reflux and dyspepsia. Its pharmacokinetics are controversial due to the use of supratherapeutic doses and the lack of sensitive methodology. Therefore, a sensitive and accurate micromethod was developed
- PMID 28225297
- Factors Affecting Gastrointestinal Absorption of Levothyroxine: A Review.
- Skelin M1, Lucijanić T2, Amidžić Klarić D3, Rešić A4, Bakula M5, Liberati-Čizmek AM5, Gharib H6, Rahelić D2.
- Clinical therapeutics.Clin Ther.2017 Feb;39(2):378-403. doi: 10.1016/j.clinthera.2017.01.005. Epub 2017 Jan 30.
- PURPOSE: Levothyroxine (LT4) is a drug with a narrow therapeutic index, applied in small amounts (micrograms), which makes interactions in the absorption phase clinically significant. The main aim of this article was to review and present the latest information on factors that affect the gastrointes
- PMID 28153426
- Premedication with simethicone and N-acetylcysteine in improving visibility during upper endoscopy: a double-blind randomized trial.
- Elvas L1, Areia M1, Brito D1, Alves S1, Saraiva S1, Cadime AT1.
- Endoscopy.Endoscopy.2017 Feb;49(2):139-145. doi: 10.1055/s-0042-119034. Epub 2016 Nov 16.
- Background and study aim Upper endoscopy is the most common method for the diagnosis of upper gastrointestinal tract diseases. The aim of this study was to determine whether premedication with simethicone or N-acetylcysteine improves mucosal visualization during upper endoscopy. Patients and metho
- PMID 27852098
Japanese Journal
- Simethicone coated cellulose as an oral contrast agent for ultrasound of the upper abdomen
Related Links
- Alamag Plus ® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Aldroxicon ® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Almacone ® (containing Aluminum Hydroxide ...
- Find patient medical information for simethicone oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. ... This product is used to relieve symptoms of extra gas such as belching ...
Related Pictures
![Simethicone - Gas-X](https://1mg.info/0/g/q/0737.jpg)
![Simethicone 125 mg,](https://1mg.info/0/g/q/0738.jpg)
![simethicone](https://1mg.info/0/g/q/0739.jpg)
![Equate Simethicone Infants'](https://1mg.info/0/g/q/0740.jpg)
![Simethicone Regular Strength Chewable](https://1mg.info/0/g/q/0741.jpg)
★リンクテーブル★
[★]
ジメチコン
- 関
- dimeticone、simethicone
[★]
ジメチコン、dimethicone、simethicone
[★]
- 英
- simethicone
- 関
- ジメチコン