UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

Evaluation of Incremental Siliconization Levels on Soluble Aggregates, Submicron and Subvisible Particles in a Prefilled Syringe Product.

Bai S1, Landsman P1, Spencer A1, DeCollibus D1, Vega F1, Temel DB1, Houde D1, Henderson O1, Brader ML2.
Journal of pharmaceutical sciences.J Pharm Sci.2016 Jan;105(1):50-63. doi: 10.1016/j.xphs.2015.10.012. Epub 2015 Dec 22.
The evaluation of stability with respect to particles in prefilled syringes is complicated by the presence of silicone oil. The mobility, colloidal characteristics, and kinetic instability of silicone oil in contact with a protein formulation may be influenced in unpredictable ways by pharmaceutical
PMID 26852839

Surfactant Effects on Particle Generation in Antibody Formulations in Pre-filled Syringes.

Gerhardt A1, Mcumber AC1, Nguyen BH1, Lewus R2, Schwartz DK1, Carpenter JF3, Randolph TW1.
Journal of pharmaceutical sciences.J Pharm Sci.2015 Dec;104(12):4056-64. doi: 10.1002/jps.24654. Epub 2015 Sep 28.
Protein aggregation and particle formation have been observed when protein solutions contact hydrophobic interfaces, and it has been suggested that this undesirable phenomenon may be initiated by interfacial adsorption and subsequent gelation of the protein. The addition of surfactants, such as poly
PMID 26413998

In Vivo Analysis of the Potency of Silicone Oil Microdroplets as Immunological Adjuvants in Protein Formulations.

Chisholm CF1, Nguyen BH1, Soucie KR1, Torres RM2, Carpenter JF3, Randolph TW1.
Journal of pharmaceutical sciences.J Pharm Sci.2015 Nov;104(11):3681-90. doi: 10.1002/jps.24573. Epub 2015 Jul 17.
Subvisible particles in a therapeutic protein product may act as adjuvants to promote unwanted immune responses against the protein. Silicone oil is used as a lubricant in prefilled syringes, and microdroplets of silicone oil are often detected in protein formulations expelled from prefilled syringe
PMID 26190624

長谷崎和洋
粉体および粉末冶金 60(12), 510-515, 2013
… The MoSi2/Mo/Nb/γ – TiAl FGMs were prepared using the spark plasma sintering (SPS) method, followed by siliconized in molten salts. …
NAID 130003393299

Preparation and High-temperature Oxidation of MoSi2/Mo/Nb/γ-TiAl Functionally Graded Materials

Ohshima Masayuki,Daio Mamoru,Fusa Mei,Tetsui Toshimitsu,Hasezaki Kazuhiro
粉体および粉末冶金 59(8), 443-447, 2012
… Mo/Nb/γ-TiAl functionally graded materials (FGMs) were prepared using a spark plasma sintering (SPS) method, and the MoSi2/Mo/Nb/γ-TiAl FGMs were then siliconized in molten salts. … The Mo/Nb/γ-TiAl FGMs were siliconized by dipping in a molten-salts mixture before heating in a mullite crucible at 1173 K for 40 h. …
NAID 130004482635

Yexi He,Zhe Gao,Wenhao Wang [他],Qiong Xiao,Lifeng Xie,Li Zeng,Guoping Zhang,Chunhua Feng,Long Wang,Xuanzong Yang
電気学会論文誌Ａ（基礎・材料・共通部門誌） 125(11), 925-928, 2005
… At the end of 2003, we tried to deposit siliconized film on vacuum vessel. …
NAID 130000085479