Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/14 00:14:39」(JST)

wiki en

Sialoadhesin is a cell adhesion molecule found on the surface of certain cells of the immune system called macrophages. It is found in especially high amounts on macrophages of the spleen, liver, lymph node, bone marrow, colon, and lungs. Also, in patients suffering from rheumatoid arthritis, the protein has been found in great amounts on macrophages of the affected tissues.^[2] It is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin superfamily (IgSF). Sialoadhesin binds to certain molecules called sialic acids. During this binding process a salt bridge (protein) is formed between a highly conserved arginine residue (from the v-set domain to the 3'-sialyllactose) and the carboxylate group of the sialic acid.^[2] Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. Alternate names for sialoadhesin include siglec-1 and CD169 (cluster of differentiation 169).^[3]

Sialoadhesin predominantly binds neutrophils, but can also bind monocytes, natural killer cells, B cells and a subset of cytotoxic T cells by interacting with sialic acid molecules in the ligands on their surfaces.^[4]

Sialaodhesin (CD169) positive macrophages, along with mesenchymal stem cells and beta-adrenergic neurons, form the hematopoietic stem cell niche in the bone marrow. CD169+ macrophages mediate signaling between the various cells and seem to promote hematopoietic stem cell retention to the niche.

References

^ PDB: 2BVE ; Zaccai NR, May AP, Robinson RC, Burtnick LD, Crocker PR, Brossmer R, Kelm S, Jones EY (February 2007). "Crystallographic and in silico analysis of the sialoside-binding characteristics of the Siglec sialoadhesin". J. Mol. Biol. 365 (5): 1469–79. doi:10.1016/j.jmb.2006.10.084. PMID 17137591.
^ ^a ^b Hartnell A, Steel J, Turley H, Jones M, Jackson DG, Crocker PR (January 2001). "Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations". Blood 97 (1): 288–96. doi:10.1182/blood.V97.1.288. PMID 11133773.
^ Varki A (2001-09-10). "Sialoadhesin, Siglec-1 (CD169)". Protein Reviews on the Web (PROW) Guide. United States National Center for Biotechnology Information (NCBI). Retrieved 2011-04-15.
^ Kelm S, Pelz A, Schauer R, Filbin M, Tang S, de Bellard M, Schnaar R, Mahoney J, Hartnell A, Bradfield P (1994). "Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily". Curr Biol 4 (11): 965–72. doi:10.1016/S0960-9822(00)00220-7. PMID 7533044.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

English Journal

Replication characteristics of eight virulent and two attenuated genotype 1 and 2 porcine reproductive and respiratory syndrome virus (PRRSV) strains in nasal mucosa explants.

Frydas IS1, Nauwynck HJ2.
Veterinary microbiology.Vet Microbiol.2016 Jan 15;182:156-62. doi: 10.1016/j.vetmic.2015.11.016. Epub 2015 Nov 25.
Porcine reproductive and respiratory syndrome virus (PRRSV) can spread in between pigs via contact and airborne route. It was shown before that the highly pathogenic PRRSV strain Lena was able to replicate 10-100 times more in the nasal mucosa compared to the low pathogenic PRRSV strain LV. In this
PMID 26711043

The CD169 sialoadhesin molecule mediates cytotoxic T cell responses to tumour apoptotic vesicles.

Black LV1, Saunderson SC1, Coutinho FP1, Muhsin-Sharafaldine MR1, Damani TT1, Dunn AC1, McLellan AD1.
Immunology and cell biology.Immunol Cell Biol.2015 Dec 9. doi: 10.1038/icb.2015.111. [Epub ahead of print]
Apoptosis leads to the fragmentation and packaging of cellular contents into discrete vesicles, a process known as 'blebbing'. Extracellular vesicles express membrane-bound sialic acids, which enable their capture by CD169 (sialoadhesin; Siglec-1) expressing macrophages in lymph node and spleen. Fur
PMID 26647968

Prognostic Significance of CD169+ Lymph Node Sinus Macrophages in Patients with Malignant Melanoma.

Saito Y1, Ohnishi K1, Miyashita A2, Nakahara S2, Fujiwara Y1, Horlad H1, Motoshima T1, Fukushima S2, Jinnin M2, Ihn H2, Takeya M1, Komohara Y3.
Cancer immunology research.Cancer Immunol Res.2015 Dec;3(12):1356-63. doi: 10.1158/2326-6066.CIR-14-0180. Epub 2015 Aug 21.
CD169 (sialoadhesin) is a sialic acid receptor that is specifically expressed on macrophages, including lymph node sinus macrophages. Animal studies suggest that CD169(+) macrophages in lymph nodes have properties in preventing cancers. In order to determine the significance of CD169(+) macrophages
PMID 26297710

Japanese Journal

Identification of sialoadhesin as a dominant lymph node counter-receptor for mouse macrophage galactose-type C-type lectin 1

KUMAMOTO Y.
J. Biol. Chem. 279, 49274-49280, 2004
NAID 30016361738

A Streptavidin-Based Neoglycoprotein Carrying More Than 140 GT1b Oligosaccharides: Quantitative Estimation of the Binding Specificity of Murine Sialoadhesin Expressed on CHO Cells^1

HASHIMOTO Yasuhiro,SUZUKI Minoru,CROCKER Paul R.,SUZUKI Akemi
The journal of biochemistry 123(3), 468-478, 1998-03-01
NAID 10005842751

Related Pictures

★リンクテーブル★

リンク元	「シアロアドヘシン」

「シアロアドヘシン」

Sialoadhesin
	Structure of the N-terimal domain of mouse sialoadhesin.
Identifiers
Symbol	SIGLEC1
Alt. symbols	SN, CD169
Entrez	6614
HUGO	11127
OMIM	600751
PDB	2BVE
RefSeq	NM_023068
UniProt	Q9BZZ2
Other data
Locus	Chr. 20 p13

　　[★]

英: sialoadhesin
同: CD169

シアル酸結合タンパク質

[pmid17137591-1] PDB: 2BVE ; Zaccai NR, May AP, Robinson RC, Burtnick LD, Crocker PR, Brossmer R, Kelm S, Jones EY (February 2007). "Crystallographic and in silico analysis of the sialoside-binding characteristics of the Siglec sialoadhesin". J. Mol. Biol. 365 (5): 1469–79. doi:10.1016/j.jmb.2006.10.084. PMID 17137591.

[Hartnell_2001-2] Hartnell A, Steel J, Turley H, Jones M, Jackson DG, Crocker PR (January 2001). "Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations". Blood 97 (1): 288–96. doi:10.1182/blood.V97.1.288. PMID 11133773.

[titlePROW_Guide:_Sialoadhesin.2C_Siglec-1_.28CD169.29-3] Varki A (2001-09-10). "Sialoadhesin, Siglec-1 (CD169)". Protein Reviews on the Web (PROW) Guide. United States National Center for Biotechnology Information (NCBI). Retrieved 2011-04-15.

[4] Kelm S, Pelz A, Schauer R, Filbin M, Tang S, de Bellard M, Schnaar R, Mahoney J, Hartnell A, Bradfield P (1994). "Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily". Curr Biol 4 (11): 965–72. doi:10.1016/S0960-9822(00)00220-7. PMID 7533044.

匿名

検索

案内

案内

sialoadhesin