シャットダウン、活動停止

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(工場などの一時的または永久的)閉鎖,操業停止

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/04 07:14:24」(JST)

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1. 非移植手術を受ける腎臓の同種移植片レシピエントに関連する問題 issues relating to the renal allograft recipient undergoing non transplant surgery
2. 外傷に伴う凝固障害 coagulopathy associated with trauma
3. 外傷性前房出血：臨床的特徴および診断 traumatic hyphema clinical features and diagnosis
4. 帝王切開分娩後の出血管理 management of postpartum hemorrhage at cesarean delivery
5. 赤血球抗原および抗体のプライマー a primer of red blood cell antigens and antibodies

English Journal

Inhibition of RSK/YB-1 signaling enhances the anti-cancer effect of enzalutamide in prostate cancer.

Shiota M1, Yokomizo A, Takeuchi A, Itsumi M, Imada K, Kashiwagi E, Inokuchi J, Tatsugami K, Uchiumi T, Naito S.Author information 1Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.AbstractBACKGROUND: Previously, we have shown that Y-box binding protein-1 (YB-1) regulates androgen receptor (AR) expression and contributes to castration resistance. However, the mechanism of YB-1 activation remains unknown. In this study, we aimed to elucidate the mechanism and role of YB-1 activation in relation to castration resistance as well as enzalutamide resistance, with a view to developing a novel therapeutic concept for castration-resistant prostate cancer (CRPC) treatment.
The Prostate.Prostate.2014 Apr 17. doi: 10.1002/pros.22813. [Epub ahead of print]
BACKGROUND: Previously, we have shown that Y-box binding protein-1 (YB-1) regulates androgen receptor (AR) expression and contributes to castration resistance. However, the mechanism of YB-1 activation remains unknown. In this study, we aimed to elucidate the mechanism and role of YB-1 activation in
PMID 24740858

Arsenic-tolerant plant-growth-promoting bacteria isolated from arsenic-polluted soils in South Korea.

Shagol CC1, Krishnamoorthy R, Kim K, Sundaram S, Sa T.Author information 1Department of Environmental and Biological Chemistry, College of Agriculture, Life and Environment Sciences, Chungbuk National University, Cheongju, Chungbuk, 361-763, Republic of Korea.AbstractThe Janghang smelter in Chungnam, South Korea started in 1936 was subsequently shutdown in 1989 due to heavy metal (loid) pollution concerns in the vicinity. Thus, there is a need for the soil in the area to be remediated to make it usable again especially for agricultural purposes. The present study was conducted to exploit the potential of arsenic (As)-tolerant bacteria thriving in the vicinity of the smelter-polluted soils to enhance phytoremediation of hazardous As. We studied the genetic and taxonomic diversity of 21 As-tolerant bacteria isolated from soils nearer to and away from the smelter. These isolates belonging to the genera Brevibacterium, Pseudomonas, Microbacterium, Rhodococcus, Rahnella, and Paenibacillus, could tolerate high concentrations of arsenite (As(III)) and arsenate (As(V)) with the minimum inhibitory concentration ranging from 3 to >20 mM for NaAsO2 and 140 to 310 mM NaH2AsO4 · 7H2O, respectively. All isolates exhibited As(V) reduction except Pseudomonas koreensis JS123, which exhibited both oxidation and reduction of As. Moreover, all the 21 isolates produced indole acetic acid (IAA), 13 isolates exhibited 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase activity, 12 produced siderophore, 17 solubilized phosphate, and 13 were putative nitrogen fixers under in vitro conditions. Particularly, Rhodococcus aetherivorans JS2210, P. koreensis JS2214, and Pseudomonas sp. JS238 consistently increased root length of maize in the presence of 100 and 200 μM As(V). Possible utilization of these As-tolerant plant-growth-promoting bacteria can be a potential strategy in increasing the efficiency of phytoremediation in As-polluted soils.
Environmental science and pollution research international.Environ Sci Pollut Res Int.2014 Apr 16. [Epub ahead of print]
The Janghang smelter in Chungnam, South Korea started in 1936 was subsequently shutdown in 1989 due to heavy metal (loid) pollution concerns in the vicinity. Thus, there is a need for the soil in the area to be remediated to make it usable again especially for agricultural purposes. The present stud
PMID 24737020

Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Interacts with Host KAP1 to Facilitate Establishment of Viral Latency.

Sun R1, Liang D, Gao Y, Lan K.Author information 1Unit of Tumor Virology, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.AbstractKaposi's sarcoma-associated herpesvirus (KSHV) typically displays two different phases in its life cycle, including the default latent phase as well as the lytic phase. There is a short period of lytic gene expression at the early stage of KSHV primary infection. The factors involved in the shutdown process of lytic gene expression are poorly identified. It has been shown that the latency-associated nuclear antigen (LANA) encoded by KSHV plays an important role in the establishment of viral latency. In screening, we identified a host protein, Krüppel-associated box domain associated protein-1 (KAP1) that bound to LANA. We validated the interaction between LANA and KAP1 in vivo and in vitro as well as their colocalization in the nucleus. We mapped out that LANA interacted with both the N- and C-terminal domains of KAP1. Based on the determined interface of LANA-KAP1 interaction, we proved that LANA recruited KAP1 to the RTA promoter region of the KSHV genome. We revealed that KAP1 was involved in transcriptional repression by LANA. We found that multiple co-occupation sites of LANA and KAP1 on the whole KSHV genome by ChIP-seq and demonstrated that LANA-recruited KAP1 played a critical role in the shutdown of lytic gene expression during the early stage of KSHV primary infection. Taken together, our data suggest that LANA interacts with KAP1 and represses lytic gene expression to facilitate the establishment of KSHV latency.
Journal of virology.J Virol.2014 Apr 16. [Epub ahead of print]
Kaposi's sarcoma-associated herpesvirus (KSHV) typically displays two different phases in its life cycle, including the default latent phase as well as the lytic phase. There is a short period of lytic gene expression at the early stage of KSHV primary infection. The factors involved in the shutdown
PMID 24741090