shuck

　 　 　

WordNet

1. remove from the shell; "shuck oysters"
2. remove the shucks from; "shuck corn"
3. an expression of disappointment or irritation

PrepTutorEJDIC

1. (トウモロコシ・クルミ・豆・カキ・ハマグリなどの)殻(から),さや,皮 / …‘の'殻(さや)を取る / 〈衣服など〉‘を'取り去る,脱ぐ
2. (不快・後悔の発声を表して)ばかな,ちぇっ

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/06 21:21:57」(JST)

wiki en

[Wiki en表示]

Shuck may refer to:

• The shell sections of grains
• Black Shuck, mythical dog
• Shuckin' and jivin'

People

• Glenn Shuck, American academic
• Henrietta Hall Shuck, American missionary
• J. B. Shuck, baseball player
• Jim Shuck, American football player
• Ryan Shuck, guitarist
• William E. Shuck, Jr., Medal of Honor recipient

UpToDate Contents

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• 1. 亜急性または慢性の手首の疼痛を有する成人の評価 evaluation of the adult with subacute or chronic wrist pain

English Journal

• Development and model testing of antemortem screening methodology to predict required drug withholds in heifers.

• Jones SA1, Salter RS2, Goldsmith T3, Quintana J2, Rapnicki P4, Shuck K5, Wells JE5, Schneider MJ6, Griffin D5.Author information 1U.S. Department of Agriculture, Agricultural Research Service, U.S. Meat Animal Research Center, Clay Center, Nebraska 68933-0166, USA; U.S. Department of Agriculture, Agricultural Research Service, U.S. Meat Animal Research Center, Clay Center, Nebraska 68933-0166, USA. shuna.jones@ars.usda.gov.2Charm Sciences, Inc., 659 Andover Street, Lawrence, Massachusetts 01843, USA.3College of Veterinary Medicine, Center for Animal Health and Food Safety, University of Minnesota, Minneapolis, Minnesota 55455, USA.4Elanco Animal Health, 2500 Innovation Way, P.O. Box 708, Greenfield, Indiana 46140, USA.5U.S. Department of Agriculture, Agricultural Research Service, U.S. Meat Animal Research Center, Clay Center, Nebraska 68933-0166, USA.6U.S. Department of Agriculture, Eastern Regional Research Center, 600 East Mermaid Lane, Wyndmoor, Pennsylvania 19038, USA.AbstractA simple, cow-side test for the presence of drug residues in live animal fluids would provide useful information for tissue drug residue avoidance programs. This work describes adaptation and evaluation of rapid screening tests to detect drug residues in serum and urine. Medicated heifers had urine, serum, and tissue biopsy samples taken while on drug treatment. Samples were tested by rapid methods and high-performance liquid chromatography (HPLC). The adapted microbial inhibition method, kidney inhibition swab test, was useful in detecting sulfadimethoxine in serum, and its response correlated with the prescribed withdrawal time for the drug, 5 to 6 days posttreatment. The lateral flow screening method for flunixin and beta-lactams, adapted for urine, was useful in predicting flunixin in liver detected by HPLC, 96 h posttreatment. The same adapted methods were not useful to detect ceftiofur in serum or urine due to a lack of sensitivity at the levels of interest. These antemortem screening test studies demonstrated that the method selected, and the sampling matrix chosen (urine or serum), will depend on the drug used and should be based on animal treatment history if available. The live animal tests demonstrated the potential for verification that an individual animal is free of drug residues before sale for human consumption.
• Journal of food protection.J Food Prot.2014 Feb;77(2):292-8. doi: 10.4315/0362-028X.JFP-13-267.
• A simple, cow-side test for the presence of drug residues in live animal fluids would provide useful information for tissue drug residue avoidance programs. This work describes adaptation and evaluation of rapid screening tests to detect drug residues in serum and urine. Medicated heifers had urine,
• PMID 24490924

• Mass Spectrometric Methods for the Analysis of Nucleoside-Protein Cross-Links: Application to Oxopropenyl-deoxyadenosine.

• Shuck SC, Rose KL, Marnett LJ.Author information Department of Biochemistry, Vanderbilt University , Nashville, Tennessee 37232, United States.AbstractElectrophilic DNA adducts produced following oxidative stress can form DNA-protein cross-links (DPCs), dramatically altering genomic maintenance pathways. Complete characterization of DPCs has been hindered, in part, because of a lack of comprehensive techniques for their analysis. We have, therefore, established a proteomics approach to investigate sites of cross-link formation using N(6)-(3-oxo-1-propenyl)-2'-deoxyadenosine (OPdA), an electrophilic DNA adduct produced from oxidative stress. OPdA was reacted with albumin and reduced with NaBH4 to stabilize DPCs. Using LC-MS/MS proteomics techniques, high-resolution peptide sequence data were obtained; however, using a database searching strategy, adducted peptides were only identified in samples subjected to chemical depurination. This strategy revealed multiple oxopropenyl adenine-lysine adducts and oxopropenyl-lysine adducts with the most reactive lysines identified to be Lys256 and Lys548. Manual interrogation of the mass spectral data provided evidence of OPdA deoxynucleoside conjugates to lysines and cross-links that underwent facile collision-induced dissociation to release an unmodified peptide without subsequent fragmentation. These fragmentations precluded adduct detection and peptide sequencing using database searching methods. Thus, comprehensive analysis of DPCs requires chemical depurination of DNA-protein reaction mixtures followed by a combination of database-dependent and manual interrogation of LC-MS/MS data using higher-energy collision-induced dissociation. In the present case, this approach revealed that OPdA selectively modifies surface lysine residues and produces nucleoside-protein cross-links and oxopropenyl lysine.
• Chemical research in toxicology.Chem Res Toxicol.2014 Jan 21;27(1):136-46. doi: 10.1021/tx400384e. Epub 2013 Dec 20.
• Electrophilic DNA adducts produced following oxidative stress can form DNA-protein cross-links (DPCs), dramatically altering genomic maintenance pathways. Complete characterization of DPCs has been hindered, in part, because of a lack of comprehensive techniques for their analysis. We have, therefor
• PMID 24359270

• Effects of TP53 mutational status on gene expression patterns across 10 human cancer types.

• Parikh N, Hilsenbeck S, Creighton CJ, Dayaram T, Shuck R, Shinbrot E, Xi L, Gibbs RA, Wheeler DA, Donehower LA.Author information Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.AbstractMutations in the TP53 tumour suppressor gene occur in half of all human cancers, indicating its critical importance in inhibiting cancer development. Despite extensive studies, the mechanisms by which mutant p53 enhances tumour progression remain only partially understood. Here, using data from the Cancer Genome Atlas (TCGA), genomic and transcriptomic analyses were performed on 2256 tumours from 10 human cancer types. We show that tumours with TP53 mutations have altered gene expression profiles compared to tumours retaining two wild-type TP53 alleles. Among 113 known p53-up-regulated target genes identified from cell culture assays, 10 were consistently up-regulated in at least eight of 10 cancer types that retain both copies of wild-type TP53. RPS27L, CDKN1A (p21CIP1 ) and ZMAT3 were significantly up-regulated in all 10 cancer types retaining wild-type TP53. Using this p53-based expression analysis as a discovery tool, we used cell-based assays to identify five novel p53 target genes from genes consistently up-regulated in wild-type p53 cancers. Global gene expression analyses revealed that cell cycle regulatory genes and transcription factors E2F1, MYBL2 and FOXM1 were disproportionately up-regulated in many TP53 mutant cancer types. Finally, > 93% of tumours with a TP53 mutation exhibited greatly reduced wild-type p53 messenger expression, due to loss of heterozygosity or copy neutral loss of heterozygosity, supporting the concept of p53 as a recessive tumour suppressor. The data indicate that tumours with wild-type TP53 retain some aspects of p53-mediated growth inhibitory signalling through activation of p53 target genes and suppression of cell cycle regulatory genes. Published by John Wiley & Sons, Ltd. www.pathsoc.org.uk.
• The Journal of pathology.J Pathol.2013 Dec 28. doi: 10.1002/path.4321. [Epub ahead of print]
• Mutations in the TP53 tumour suppressor gene occur in half of all human cancers, indicating its critical importance in inhibiting cancer development. Despite extensive studies, the mechanisms by which mutant p53 enhances tumour progression remain only partially understood. Here, using data from the
• PMID 24374933

• Replication, repair, and translesion polymerase bypass of N⁶-oxopropenyl-2'-deoxyadenosine.

• Maddukuri L, Shuck SC, Eoff RL, Zhao L, Rizzo CJ, Guengerich FP, Marnett LJ.Author information A. B. Hancock Jr. Memorial Laboratory for Cancer Research, †Department of Biochemistry, ‡Department of Chemistry, and §Department of Pharmacology, Center in Molecular Toxicology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-0146, United States.AbstractThe oxidative stress products malondialdehyde and base propenal react with DNA bases forming the adduction products 3-(2'-deoxy-β-D-erythro-pentofuranosyl)pyrimido[1,2-a]purin-10(3H)-one (M1dG) and N(6)-(oxypropenyl)-2'-deoxyadenosine (OPdA). M1dG is mutagenic in vivo and miscodes in vitro, but little work has been done on OPdA. To improve our understanding of the effect of OPdA on polymerase activity and mutagenicity, we evaluated the ability of the translesion DNA polymerases hPols η, κ, and ι to bypass OPdA in vitro. hPols η and κ inserted dNTPs opposite the lesion and extended the OPdA-modified primer to the terminus. hPol ι inserted dNTPs opposite OPdA but failed to fully extend the primer. Steady-state kinetic analysis indicated that these polymerases preferentially insert dTTP opposite OPdA, although less efficiently than opposite dA. Minimal incorrect base insertion was observed for all polymerases, and dCTP was the primary mis-insertion event. Examining replicative and repair polymerases revealed little effect of OPdA on the Sulfolobus solfataricus polymerase Dpo1 or the Klenow fragment of Escherichia coli DNA polymerase I. Bacteriophage T7 DNA polymerase displayed a reduced level of OPdA bypass compared to unmodified DNA, and OPdA nearly completely blocked the activity of base excision repair polymerase hPol β. This work demonstrates that bypass of OPdA is generally error-free, modestly decreases the catalytic activity of most polymerases, and blocks hPol β polymerase activity. Although mis-insertion opposite OPdA is relatively weak, the efficiency of bypass may introduce A → G transitions observed in vivo.
• Biochemistry.Biochemistry.2013 Dec 3;52(48):8766-76. doi: 10.1021/bi401103k. Epub 2013 Nov 15.
• The oxidative stress products malondialdehyde and base propenal react with DNA bases forming the adduction products 3-(2'-deoxy-β-D-erythro-pentofuranosyl)pyrimido[1,2-a]purin-10(3H)-one (M1dG) and N(6)-(oxypropenyl)-2'-deoxyadenosine (OPdA). M1dG is mutagenic in vivo and miscodes in vitro, but lit
• PMID 24171480

Japanese Journal

• 人工股関節全置換術の shuck test の再現性の検討

• 高尾 正樹,西井 孝,坂井 孝司,吉川 秀樹,菅野 伸彦
• 中部日本整形外科災害外科学会雑誌. 中部日本整形外科災害外科学会抄録 54(4), 655-656, 2011-07-01
• NAID 10029661351

• 6060 祭りにおけるコミュニティの可視化 : 能登半島地震被災集落・道下における2009年夏祭り調査報告(4)(祭り・祭祀空間,農村計画)

• 白浜 晋平,山崎 寿一,竹田 和樹,金 斗換,川口 麻子,久保 佳与子
• 学術講演梗概集. E-2, 建築計画II, 住居・住宅地, 農村計画, 教育 2010, 491-492, 2010-07-20
• NAID 110008112526

• 6057 祭りにみる集落の社会構造の考察 : 能登半島地震被災集落・道下における2009年夏祭り調査報告(1)(祭り・祭祀空間,農村計画)

• 白浜 晋平,山崎 寿一,竹田 和樹,金 斗換,川口 麻子,久保 佳与子
• 学術講演梗概集. E-2, 建築計画II, 住居・住宅地, 農村計画, 教育 2010, 485-486, 2010-07-20
• NAID 110008112523

• Cloning and characterization of two K^+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3)

• SHUCK M. E.
• J Biol Chem 272, 586-593, 1997
• NAID 80009457214

Related Links

• Shuck | Define Shuck at Dictionary.com

noun 1. a husk or pod, as the outer covering of corn, hickory nuts, chestnuts, etc. 2. Usually, shucks. Informal. something useless or worthless: They don't care shucks ... verb (used with object) Slang. to deceive or lie to.

• shuckの意味 - 英和辞書 - goo辞書

shuckとは。意味や和訳。[名]1 ((米))（トウモロコシ・クリなどの）皮, さや, 殻；（カキ・ハマグリなどの）殻.2 ((通例〜s))((略式))無価値なもの；いかさま；うそつき, 不誠実な人not worth shucks少しの値うちもない. [動](他)1 ((米... - goo ...

• Photos | shuck

Home Restaurant Shuck Bar Wine Lists Functions Photos Whats On Staff Contact Become a Shuck VIP Member. Ask our friendly wait staff for an application. Saturday nights @ Shuck Bar with Danny Waho entertaining you from ...

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