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1. 性腺刺激ホルモン（ゴナドトロピン）放出ホルモンの生理学physiology of gonadotropin releasing hormone [show details]
…pulsatile release of gonadotropin-releasing hormone (GnRH). In response to GnRH (also called luteinizing hormone-releasing hormone or LHRH), the pituitary releases pulses of the gonadotropins, luteinizing hormone …
2. 原因不明の不妊症unexplained infertility [show details]
…addition, gonadotropin/IUI is associated with a high rate of multiple gestation and increases the cost out of proportion to the modest improvement in outcome (live birth rate 32 percent for gonadotropin/IUI …
3. 続発性性腺機能低下を呈する男性における生殖能の誘導induction of fertility in men with secondary hypogonadism [show details]
…Men who have pituitary disease can be treated with gonadotropins, while those with hypothalamic disease can be treated with gonadotropins or gonadotropin-releasing hormone (GnRH). The diagnosis of secondary …
4. 多嚢胞性卵巣症候群における排卵誘発のための腹腔鏡下手術laparoscopic surgery for ovulation induction in polycystic ovary syndrome [show details]
…preferred laparoscopic ovarian drilling over gonadotropin ovulation induction . A summary of the advantages and disadvantages of laparoscopic surgery and gonadotropin therapy for ovulation induction is shown …
5. 性腺刺激ホルモン放出ホルモン単独欠乏症（特発性低ゴナドトロピン性性腺機能低下症）isolated gonadotropin releasing hormone deficiency idiopathic hypogonadotropic hypogonadism [show details]
…found separately. In boys, puberty can be induced with testosterone, exogenous gonadotropins, or pulsatile gonadotropin-releasing hormone (GnRH) therapy. The latter two options also induce spermatogenesis …

English Journal

Paper-based immunocapture for targeted protein analysis.

Skjærvø Ø, Solbakk EJ, Halvorsen TG, Reubsaet L.
Talanta. 2019 Apr;195()764-770.
A novel sampling concept for mass spectrometric bottom-up targeted protein analysis is here demonstrated with polymeric sampling spots integrated with instant immunocapture for analysis of dried matrix spots. The polymers 2-hydroxyethyl methacrylate-co-2-vinyl-4,4-dimethyl azlactone (pHEMA-VDM) and
PMID 30625614

A Multicenter, Randomized, Equivalence Trial of a New Recombinant Human Chorionic Gonadotropin Preparation versus Ovitrelle for Ovulation in Women Undergoing Intrauterine Insemination Following Ovarian Stimulation.

Majumdar A, Sachan R, Nandanwar YS, Mayekar RV, Soni N, Banker MR, Vaidya RS, Arora M, Godbole GP, Daftary GV, Divekar GH, John J.
Journal of human reproductive sciences. ;12(1)53-58.
A new indigenous recombinant human chorionic gonadotropin (r-hCG) has been developed in India with a comparable pharmacological profile to that of Ovitrelle (Merck Serono). This study aims to compare the efficacy and safety of the new r-hCG with that of Ovitrelle for induction of ovulation in women
PMID 31007468

FSHB -211 G>T is a major genetic modulator of reproductive physiology and health in childbearing age women.

Rull K, Grigorova M, Ehrenberg A, Vaas P, Sekavin A, Nõmmemees D, Adler M, Hanson E, Juhanson P, Laan M.
Human reproduction (Oxford, England). 2018 05;33(5)954-966.
Are the genetic variants FSHB -211 G>T (rs10835638), FSHR c.2039 A>G (Asn680Ser, rs6166) and FSHR -29 G>A (rs1394205) associated with serum FSH, LH and anti-Müllerian hormone (AMH) levels in reproductive age women, their menstrual cycle parameters and risk of infertility? Only the FSHB -211 G>T var
PMID 29617818

Japanese Journal

Inhibitory Effect of Thyroid Blocking Antibody (TBAb) on the Thyroid Stimulatory Effect of Human Chorionic Gonadotropin (HCG) and Equine Chorionic Gonadotropin (ECG)

OCHI YUKIO,HAMAZU MASANARI,KAJITA YOSHIHIRO,HACHIYA TAKASHI,HAMAOKI MASARU
Endocrine journal 57(4), 311-315, 2010-04-01
… We examined the inhibitory effect of thyroid blocking antibody (TBAb) on the thyroid stimulating activity of human chorionic gonadotropin (HCG) and equine CG (ECG). … Both HCG and ECG preparations showed weak TBI activity in the presence of small amounts of protein [bovine serum albumin (BSA)] but were negative in the presence of large amounts of protein [normal human serum (NHS) or BSA]. …
NAID 10029584318

卵胞培養システムからみた卵胞発育機序の解明および副作用予防のための最適排卵誘発法の確立

安藤一道
日本産科婦人科學會雜誌 58(10), 1629-1637, 2006-10-01
… Our results clarified that hMG preparation acts detrimentally on follicles from androgen-sterilized mice by increasing the sensitivity of type 4 follicles to FSH and by inducing the luteinization on type 5 follicles. … To prevent adverse effects in ovulation induction using gonadotropin, we compare the efficacy and safety of the fixed-dose, the step-down, and the low-dose step-up regimens of hMG for women with polycystic ovary syndrome (PCOS). …
NAID 110004823028

前立腺癌(既治療例)に対する3ヵ月徐放性LH-RH agonist,TAP-144-SR(3M)(リュープリンSR注射用キット11.25)の臨床効果の検討

小磯謙吉,赤座英之,内藤誠二,宇佐美道之,塚本泰司,島崎淳,古武敏彦,山中英壽,大橋靖雄,吉中亮治,小野内仁志,横川潔
泌尿器科紀要 48(12), 781-795, 2002-12
前立腺癌103例を対象に,24週で被験薬TAP-144-SR(3M)(TAP-144として11.25mg含有)2回投与(A群)と,対照薬TAP-144-SR(1M)(TAP-144として3.75mg含有)6回投与(B群)に無作為割付した.血清中テストステロン濃度の去勢レベル維持率は両群とも100%であった.前立腺癌取り扱い規約中の「前立腺癌の非観血的治療効果判定基準」にしたがった総合効果の維持率は …
NAID 120002142386