同: SAP

WordNet

an artifact that is one of the individual parts of which a composite entity is made up; especially a part that can be separated from or attached to a system; "spare components for cars"; "a component or constituent element of a system" (同)constituent, element
an abstract part of something; "jealousy was a component of his character"; "two constituents of a musical composition are melody and harmony"; "the grammatical elements of a sentence"; "a key factor in her success"; "humor: an effective ingredient of a s (同)constituent, element, factor, ingredient
(pathology) a waxy translucent complex protein resembling starch that results from degeneration of tissue
a non-nitrogenous food substance consisting chiefly of starch; any substance resembling starch
the 16th letter of the Roman alphabet (同)p
an amber, watery fluid, rich in proteins, that separates out when blood coagulates (同)blood_serum
a river in western Thailand; a major tributary of the Chao Phraya (同)Ping River

PrepTutorEJDIC

構成している,成分の / 構成要素,成分
parking
phosphorusの化学記号
リンパ液 / 血清

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/22 16:33:44」(JST)

wiki en

The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid".^[1] APCS is its human gene.^[2]

In amyloidosis

AP makes up 14% of the dry mass of amyloid deposits^[3] and is thought to be an important contributor to the pathogenesis of a related group of diseases called the Amyloidoses.^[4] These conditions are characterised by the ordered aggregation of normal globular proteins and peptides into insoluble fibres which disrupt tissue architecture and are associated with cell death. AP is thought to decorate and stabilise aggregates by preventing proteolytic cleavage and hence inhibiting fibril removal via the normal protein scavenging mechanisms.^[5] This association is utilised in the routine clinical diagnostic technique of SAP scintigraphy whereby radio-labelled protein is injected into patients to locate areas of amyloid deposition.^[6] The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of a compound called CPHPC (R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxohexanoyl] pyrrolidine-2-carboxylic acid), a small molecule able to strip AP from deposits by reducing levels of circulating SAP.^[7]

Structure

SAP is a member of the pentraxins family, characterised by calcium dependent ligand binding and distinctive flattened β-jellyroll structure similar to that of the legume lectins.^[8] The name "pentraxin" is derived from the Greek word for five (penta) and berries (ragos) relating to the radial symmetry of five monomers forming a ring approximately 95 Å across and 35 Å deep. Human SAP has 51% sequence homology with C-reactive protein (CRP), a classical acute phase response plasma protein, and is a more distant relative to the "long" pentraxins such as PTX3 (a cytokine modulated molecule) and several neuronal pentraxins. Both SAP and CRP are evolutionary conserved in all vertebrates and also found in distant invertebrates such as the horseshoe crab (Limulus polyphemus).^[9]

References

^ Cathcart ES, Shirahama T, Cohen AS (1967). "Isolation and identification of a plasma component of amyloid". Biochim. Biophy. Acta. 147: 392–393.
^ "Entrez Gene: APCS amyloid P component, serum".
^ Skinner M, Pepys MB, Cohen AS, Heller LM, Lian JB (1980). Freitas, Antonio Falcão de; Glenner, George G.; Costa, Pedro Pinho e. editors, ed. Amyloid and amyloidosis: proceedings of the Third International Symposium on Amyloidosis, Póvoa de Varzim, Portugal, 23–28 September 1979. Amsterdam: Excerpta Medica. pp. 384–391. ISBN 0-444-90124-8.
^ Botto M, Hawkins PN, Bickerstaff MC, Herbert J, Bygrave AE, McBride A, Hutchinson WL, Tennent GA, Walport MJ, Pepys MB (1997). "Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene". Nat. Med. 3 (8): 855–9. doi:10.1038/9544. PMID 9256275.
^ Tennent GA, Lovat LB, Pepys MB (1995). "Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis" (PDF). Proc. Natl. Acad. Sci. U.S.A. 92 (10): 4299–303. doi:10.1073/pnas.92.10.4299. PMC 41931. PMID 7753801.
^ Hawkins PN, Pepys MB (1995). "Imaging amyloidosis with radiolabelled SAP". Eur J Nucl Med 22 (7): 595–9. doi:10.1007/BF01254559. PMID 7498219.
^ Pepys MB, Herbert J, Hutchinson WL, Tennent GA, Lachmann HJ, Gallimore JR, Lovat LB, Bartfai T, Alanine A, Hertel C, Hoffmann T, Jakob-Roetne R, Norcross RD, Kemp JA, Yamamura K, Suzuki M, Taylor GW, Murray S, Thompson D, Purvis A, Kolstoe S, Wood SP, Hawkins PN (2002). "Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis". Nature 417 (6886): 254–9. doi:10.1038/417254a. PMID 12015594.
^ Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP (1994). "Structure of pentameric human serum amyloid P component". Nature 367 (6461): 338–45. doi:10.1038/367338a0. PMID 8114934.
^ Pepys MB, Booth DR, Hutchinson WL, Gallimore JR, Collins PM, Hohenester E (1997). "Amyloid P component. A critical review". Amyloid-International Journal of Experimental and Clinical Investigation 4: 274–295.

UpToDate Contents

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1. 続発性（AA）アミロイドーシスの病因 pathogenesis of secondary aa amyloidosis
2. 免疫グロブリン軽鎖（AL）アミロイドーシス（原発性アミロイドーシス）の臨床像、
検査所見、および診断 clinical presentation laboratory manifestations and diagnosis of immunoglobulin light chain al amyloidosis primary amyloidosis
3. 続発性（AA）アミロイドーシスの原因および診断並びにリウマチ性疾患との関連 causes and diagnosis of secondary aa amyloidosis and relation to rheumatic diseases
4. 腎アミロイドーシス renal amyloidosis
5. アミロイド疾患の遺伝的要因 genetic factors in the amyloid diseases

English Journal

Circulatory CNP Rescues Craniofacial Hypoplasia in Achondroplasia.

Yamanaka S1, Nakao K1, Koyama N1, Isobe Y1, Ueda Y2, Kanai Y2, Kondo E2, Fujii T2, Miura M2, Yasoda A2, Nakao K3, Bessho K1.
Journal of dental research.J Dent Res.2017 Dec;96(13):1526-1534. doi: 10.1177/0022034517716437. Epub 2017 Jun 23.
PMID 28644737

Metalloproteomic and differential expression in plasma in a rat model of type 1 diabetes.

Pereira Braga C1, Cavalcante Souza Vieira J2, Lima Leite A3, Henrique Fernandes AA2, Rabelo Buzalaf MA3, Magalhães Padilha P2.
International journal of biological macromolecules.Int J Biol Macromol.2017 Nov;104(Pt A):414-422. doi: 10.1016/j.ijbiomac.2017.06.032. Epub 2017 Jun 8.
PMID 28601647

Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance.

Kanai Y1, Yasoda A1, Mori KP2, Watanabe-Takano H3, Nagai-Okatani C4, Yamashita Y1, Hirota K1, Ueda Y1, Yamauchi I1, Kondo E1, Yamanaka S5, Sakane Y1, Nakao K5, Fujii T1, Yokoi H2,6, Minamino N4, Mukoyama M6,7, Mochizuki N3,6, Inagaki N1.
The Journal of clinical investigation.J Clin Invest.2017 Nov 1;127(11):4136-4147. doi: 10.1172/JCI94912. Epub 2017 Oct 9.
PMID 28990933

Japanese Journal

Up-Regulation of MUC2 Mucin Expression by Serum Amyloid A3 Protein in Mouse Colonic Epithelial Cells

Journal of Veterinary Medical Science 76(7), 985-991, 2014
NAID 130003391314

Effects of Serum Amyloid A and Lysophosphatidylcholine on Intracellular Calcium Concentration in Human Coronary Artery Smooth Muscle Cells

International Heart Journal 52(3), 185-193, 2011
NAID 130000770919

最終講義 : 我が学問 : 透析アミロイドーシスの研究と共に

新潟医学会雑誌 123(12), 599-604, 2009-12
NAID 120005457461

「SAP」

Amyloid P component, serum
	Cartoon model of SAP showing helices in red, sheets in yellow and coils in green.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1GYK, 1LGN, 1SAC, 2A3W, 2A3X, 2A3Y, 2W08, 3D5O, 3KQR, 4AVS, 4AVT, 4AVV, 4AYU
Identifiers
Symbols	APCS ; HEL-S-92n; PTX2; SAP
External IDs	OMIM: 104770 MGI: 98229 HomoloGene: 123932 ChEMBL: 4929 GeneCards: APCS Gene
Gene ontology
Molecular function	• complement component C1q binding; • calcium ion binding; • carbohydrate binding; • virion binding; • unfolded protein binding;
Cellular component	• extracellular region; • extracellular space; • nucleus; • extracellular matrix; • protein complex; • extracellular exosome; • blood microparticle;
Biological process	• negative regulation of acute inflammatory response; • protein folding; • acute-phase response; • negative regulation by host of viral exo-alpha-sialidase activity; • negative regulation by host of viral glycoprotein metabolic process; • innate immune response; • negative regulation of monocyte differentiation; • negative regulation of viral entry into host cell; • negative regulation of viral process; • chaperone-mediated protein complex assembly; • negative regulation of wound healing; • negative regulation of exo-alpha-sialidase activity; • negative regulation of glycoprotein metabolic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

　　[★]

血清アルカリホスファターゼ、血清アミロイドP成分

関: serum amyloid P-component

同: serum amyloid P component

「血清アルカリホスファターゼ」

　　[★]

英

(n

SAP

関: 血清アミロイドP成分

-SAP

同: serum amyloid P component

「serum amyloid P-component」

　　[★] 血清アミロイドP成分

関: SAP

「component」

　　[★]

n.

成分、構成成分、構成要素、コンポーネント

関: building block、composition、constituent、element、ingredient、moiety

「P」

　　[★]

「amyloid」

　　[★]

アミロイド

関: amyloid fibril、amyloid protein

「p」

　　[★]

ピコ

10の-12乗

関: pico

「Pd」

　　[★] パラジウム palladium 　

[Cathcart_1967-1] Cathcart ES, Shirahama T, Cohen AS (1967). "Isolation and identification of a plasma component of amyloid". Biochim. Biophy. Acta. 147: 392–393.

[entrez-2] "Entrez Gene: APCS amyloid P component, serum".

[isbn0-444-90124-8-3] Skinner M, Pepys MB, Cohen AS, Heller LM, Lian JB (1980). Freitas, Antonio Falcão de; Glenner, George G.; Costa, Pedro Pinho e. editors, ed. Amyloid and amyloidosis: proceedings of the Third International Symposium on Amyloidosis, Póvoa de Varzim, Portugal, 23–28 September 1979. Amsterdam: Excerpta Medica. pp. 384–391. ISBN 0-444-90124-8.

[pmid9256275-4] Botto M, Hawkins PN, Bickerstaff MC, Herbert J, Bygrave AE, McBride A, Hutchinson WL, Tennent GA, Walport MJ, Pepys MB (1997). "Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene". Nat. Med. 3 (8): 855–9. doi:10.1038/9544. PMID 9256275.

[pmid7753801-5] Tennent GA, Lovat LB, Pepys MB (1995). "Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis" (PDF). Proc. Natl. Acad. Sci. U.S.A. 92 (10): 4299–303. doi:10.1073/pnas.92.10.4299. PMC 41931. PMID 7753801.

[pmid7498219-6] Hawkins PN, Pepys MB (1995). "Imaging amyloidosis with radiolabelled SAP". Eur J Nucl Med 22 (7): 595–9. doi:10.1007/BF01254559. PMID 7498219.

[pmid12015594-7] Pepys MB, Herbert J, Hutchinson WL, Tennent GA, Lachmann HJ, Gallimore JR, Lovat LB, Bartfai T, Alanine A, Hertel C, Hoffmann T, Jakob-Roetne R, Norcross RD, Kemp JA, Yamamura K, Suzuki M, Taylor GW, Murray S, Thompson D, Purvis A, Kolstoe S, Wood SP, Hawkins PN (2002). "Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis". Nature 417 (6886): 254–9. doi:10.1038/417254a. PMID 12015594.

[pmid8114934-8] Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP (1994). "Structure of pentameric human serum amyloid P component". Nature 367 (6461): 338–45. doi:10.1038/367338a0. PMID 8114934.

[Pepys_1997-9] Pepys MB, Booth DR, Hutchinson WL, Gallimore JR, Collins PM, Hohenester E (1997). "Amyloid P component. A critical review". Amyloid-International Journal of Experimental and Clinical Investigation 4: 274–295.

リンク元	「SAP」「血清アルカリホスファターゼ」
拡張検索	「serum amyloid P-component」
関連記事	「component」「P」「amyloid」「p」「Pd」

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案内

案内

serum amyloid P component