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Two
serotypes 1a and 1b with antigens 2a and 2b on surface.
Serotype or serovar refers to distinct variations within a species of bacteria or viruses or among immune cells of different individuals. These microorganisms, viruses, or cells are classified together based on their cell surface antigens, allowing the epidemiologic classification of organisms to the sub-species level.[1][2][3] A group of serovars with common antigens is called a serogroup.
Serotyping often plays an essential role in determining species and subspecies. The Salmonella genus of bacteria, for example, has been determined to have over 4400 serotypes, including Salmonella enterica serovar Typhimurium, S. enterica serovar Typhi, and S. enterica serovar Dublin.[2] Vibrio cholerae, the species of bacteria that causes cholera, has over 200 serotypes, based on cell antigens. Only two of them have been observed to produce the potent enterotoxin that results in cholera: 0:1 and 0:139.
Serotypes were discovered by the American microbiologist Rebecca Lancefield in 1933.[4]
Contents
- 1 Role in organ transplantation
- 1.1 Human leukocyte antigens
- 2 See also
- 3 References
- 4 External links
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Role in organ transplantation
Agglutination of HLA-A3 positive red blood cells (RBCs) with anti-A3 alloreactive antisera containing Anti-A3 IgM
The immune system is capable of discerning a cell as being 'self' or 'non-self' according to that cell's serotype. In humans, that serotype is largely determined by human leukocyte antigen (HLA), the human version of the major histocompatibility complex. Cells determined to be non-self are usually recognized by the immune system as foreign, causing an immune response, such as hemagglutination. Serotypes differ widely between individuals; therefore, if cells from one human (or animal) are introduced into another random human, those cells are oftentimes determined to be non-self because they do not match the self-serotype. For this reason, transplants between genetically non-identical humans often induce a problematic immune response in the recipient, leading to transplant rejection. In some situations this effect can be reduced by serotyping both recipient and potential donors to determine the closest HLA match.[5]
Human leukocyte antigens
Serotypes according the HLA (MHC) locus
HLA Locus |
# of Serotypes |
Broad Antigens |
Split Antigens |
A |
25 |
4 |
15 |
B |
50 |
9 |
|
C* |
12 |
1 |
|
DR |
21 |
4 |
|
DQ |
8 |
2 |
|
DP* |
|
|
|
*DP and many Cw require SSP-PCR for typing. |
See also
References
- ^ Baron EJ (1996). Classification. In: Baron's Medical Microbiology (Baron S et al., eds.) (4th ed.). Univ of Texas Medical Branch. ISBN 0-9631172-1-1. (via NCBI Bookshelf).
- ^ a b Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN 0-8385-8529-9.
- ^ "serovar." The American Heritage Medical Dictionary. 2007. Houghton Mifflin Company 24 Oct. 2009 http://medical-dictionary.thefreedictionary.com/serovar
- ^ Lancefield RC (1933). "A SEROLOGICAL DIFFERENTIATION OF HUMAN AND OTHER GROUPS OF HEMOLYTIC STREPTOCOCCI" (abstract). J Exp Med 57 (4): 571–95. doi:10.1084/jem.57.4.571. PMC 2132252. PMID 19870148.
- ^ Christoph Frohn, Lutz Fricke, Jan-Christoph Puchta, and Holger Kirchner. The effect of HLA-C matching on acute renal transplant rejection. Nephrol. Dial. Transplant. 16: 355-360. http://ndt.oxfordjournals.org/cgi/content/full/16/2/355
External links
- HLA Allele and Haplotype Frequency Database
Surface antigens
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Major histocompatibility complex/
Human leukocyte antigen |
MHC class I |
- HLA-A
- HLA-B
- HLA-C
- HLA-E
- HLA-F
- HLA-G
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MHC class II |
- HLA-DM
- HLA-DO
- HLA-DP
- HLA-DQ
- HLA-DR
- Minor histocompatibility antigen
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Other |
- Arrestin
- Calgranulin
- Blood group antigens
- Cell adhesion molecules
- Differentiation antigens
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cell/phys/auag/auab/comp, igrc
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UpToDate Contents
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English Journal
- Reassessment of Cronobacter spp. originally isolated as Enterobacter sakazakii from infant food.
- Akineden Ö1, Heinrich V2, Gross M3, Usleber E2.
- Food microbiology.Food Microbiol.2017 Aug;65:44-50. doi: 10.1016/j.fm.2017.01.021. Epub 2017 Feb 1.
- PMID 28400018
- Enhancing the sensitivity of Dengue virus serotype detection by RT-PCR among infected children in India.
- Ahamed SF1, Vivek R2, Kotabagi S3, Nayak K4, Chandele A5, Kaja MK6, Shet A7.
- Journal of virological methods.J Virol Methods.2017 Jun;244:46-54. doi: 10.1016/j.jviromet.2017.02.014. Epub 2017 Feb 28.
- PMID 28254680
- Characteristics of CI children with complicated middle ear infections.
- Hoberg S1, Danstrup C2, Laursen B1, Petersen NK2, Udholm N2, Kamarauskas GA2, Ovesen T1,3.
- Cochlear implants international.Cochlear Implants Int.2017 May;18(3):136-142. doi: 10.1080/14670100.2017.1289298. Epub 2017 Feb 24.
- PMID 28235386
Japanese Journal
- High-Level Genetic Diversity among Invasive Streptococcus pneumoniae Isolates in Turkey
- Multiplex PCR serogrouping of Listeria monocytogenes isolated in Japan
- Characterization of the Shiga toxin-producing <i>Escherichia coli</i> isolated from human between 2011 and 2014
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