関: Senegae Radix

WordNet

perennial bushy herb of central and southern United States having white flowers with green centers and often purple crest; similar to Seneca snakeroot (同)Polygala alba
dried root of two plants of the genus Polygala containing an irritating saponin
100 sene equal 1 tala in Western Samoa

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/03/23 20:40:40」(JST)

wiki en

[Wiki en表示]

Senega is the dried root of the Polygala senega once used medicinally.

Use

In 1911, senega was official in the British and United States pharmacopoeias. Senega contains an active ingredient, saponin. Senega is used chiefly as a stimulating expectorant in chronic bronchitis. It is occasionally used as a diuretic in renal dropsy. It is a cardiac depressant, and is contra-indicated in diseased conditions of the heart. It has a tendency to upset the digestion, and is therefore only used in combination with other drugs in what are termed expectorant mixtures. It was formerly used as an antidote for snake bites. It is used in a freely available cough mixture called "Senega and Ammonia" which formerly contained a small amount of chloroform, but the chloroform is no longer permitted under current regulations.

Dosage and administration

Senega is usually taken orally in dosages equivalent to 0.5-1 gram of the powdered root.^[1]

Toxicology

Saponins are shown to be very irritating and haemolytic. Taken orally these adverse effects seem to be bypassed. Caution should be taken if a sensitivity does exist or if taken in high doses. The most common adverse side effects are nausea and vomiting.^[1]

External links

R05CA06

References

^ ^a ^b Heinrich, Michael, A. D. Kinghorn, and J. D. Phillipson (2004). Fundamentals of Pharmacognosy and Phytotherapy. Churchill Livingstone. ISBN 0-43-07132-2.

This article incorporates text from a publication now in the public domain: Chisholm, Hugh, ed. (1911). Encyclopædia Britannica (11th ed.). Cambridge University Press.

This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it.

This rosid article is a stub. You can help Wikipedia by expanding it.

English Journal

Anticancer potentials of root extract of Polygala senega against benzo[a]pyrene-induced lung cancer in mice.

Paul S1, Bhattacharyya SS, Samaddar A, Boujedaini N, Khuda-Bukhsh AR.
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.Zhong Xi Yi Jie He Xue Bao.2011 Mar;9(3):320-7.
OBJECTIVE: To evaluate anticancer potentials of Polygala senega on lung cancer induced by benzo[a]pyrene (B[a]P) in mice.METHODS: Swiss albino mice were divided into five groups with each containing six animals. Group 1 served as control, and the animals received olive oil as vehicle. Group 2 animal
PMID 21419086

Anticancer Potentials of Root Extract of Polygala senega and Its PLGA Nanoparticles-Encapsulated Form.

Paul S1, Bhattacharyya SS, Boujedaini N, Khuda-Bukhsh AR.
Evidence-based complementary and alternative medicine : eCAM.Evid Based Complement Alternat Med.2011;2011. pii: 517204. doi: 10.1155/2011/517204. Epub 2010 Sep 21.
Ethanolic extract of Polygala senega (EEPS) had little or no cytotoxic effects on normal lung cells, but caused cell death and apoptosis to lung cancer cell line A549. In the present paper, ethanolic root extract of P. senega (EEPS) was nanoencapsulated (size: 147.7 nm) by deploying a biodegradabl
PMID 20953431

Anti-angiogenic effect of triterpenoidal saponins from Polygala senega.

Arai M1, Hayashi A, Sobou M, Ishida S, Kawachi T, Kotoku N, Kobayashi M.
Journal of natural medicines.J Nat Med.2011 Jan;65(1):149-56. doi: 10.1007/s11418-010-0477-7. Epub 2010 Nov 2.
Senegasaponins [senegin II (1), senegin III (2), senegin IV (3), senegasaponin a (4), and senegasaponin b (5)] from Polygala senega were re-discovered as selective anti-proliferative substances against human umbilical vein endothelial cells (HUVECs). Senegasaponins (1-5) showed anti-proliferative ac
PMID 21042868

In vitro and in vivo studies demonstrate anticancer property of root extract of Polygala senega.

Paul S1, Mandal SK, Bhattacharyya SS, Boujedaini N, Khuda-Bukhsh AR.
Journal of acupuncture and meridian studies.J Acupunct Meridian Stud.2010 Sep;3(3):188-96. doi: 10.1016/S2005-2901(10)60035-0.
Polygala senega is extensively used in traditional systems of medicine against various lung diseases including cancer. In the present study we tested the anticancer potentials of ethanolic extract of roots of P. senega (generally used as a homeopathic drug) in a mammalian model, where mice, in vivo,
PMID 20869020

Japanese Journal

Anti-angiogenic effect of triterpenoidal saponins from Polygala senega

Journal of natural medicines 65(1), 149-156, 2011-01-20
NAID 10029460687

ヒロハセネガ(Polygala senega L.var.latifolia Torrey et Gray)の連作障害

生薬學雜誌 : shoyakugaku zasshi : the Japanese journal of pharmacognosy 62(2), 43-47, 2008
NAID 110008729798

Studies of the Active Substances in Herbs Used for Hair Treatment. III. Isolation of Hair-Regrowth Substances form Polygara senega var. latifolia TORR. et GRAY

Biological & pharmaceutical bulletin 22(11), 1249-1250, 1999-11-15
NAID 110003639586

Bioactive Saponins and Glycosides. II. Senegae Radix (2): Chemical St4ructures, Hypoglycemic Activity, and Ethanol Absorption-Inhibitory Effect of E-Senegasaponin c, Z-Senegasaponin c, and Z-Senegins II, III, IV

Chemical & pharmaceutical bulletin 44(7), 1305-1313, 1996-07-15
NAID 110003632076

「セネガ」

　　[★]

英: senega, senega root, senega snake root
ラ: Senegae Radix, senegae radix

[pcog-0] Heinrich, Michael, A. D. Kinghorn, and J. D. Phillipson (2004). Fundamentals of Pharmacognosy and Phytotherapy. Churchill Livingstone. ISBN 0-43-07132-2.

匿名

検索

案内

案内

senega