WordNet
- any malignant tumor derived from epithelial tissue; one of the four major types of cancer
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- がん,がん腫
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/21 07:22:07」(JST)
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| Sebaceous carcinoma |
| Classification and external resources |
Micrograph of a sebaceous carcinoma (left of image) metastatic to the parotid gland (right of image). H&E stain.
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| ICD-10 |
C44 (ILDS C44.L46) |
| eMedicine |
article/1101433 |
Sebaceous carcinoma is an uncommon and aggressive malignant cutaneous tumor.[1] Most are typically about 10 mm in size at presentation.[2] This neoplasm is thought to arise from sebaceous glands in the skin and, therefore, may originate anywhere in the body where these glands are found. Because the periocular region is rich in this type of gland, this region is a common site of origin.[3][4] The etiology of these lesions are, in the vast majority of cases, unknown. Occasional cases may be associated with Muir-Torre syndrome.[5][6]
This type of cancer usually has a poor prognosis because of a high rate of metastasis.[2]
Contents
- 1 Pathophysiology
- 2 Morphology
- 3 Treatment
- 4 See also
- 5 References
Pathophysiology
The cell of origin is usually unknown. Sebaceous gland carcinoma clearly resembles normal sebaceous glands and is thought to arise from them.[1][2]
Morphology
Well-differentiated and moderately differentiated sebaceous carcinoma tend to exhibit vacuolization within the cytoplasm of the tumor cells.[7] Histology may mimic basal cell carcinoma.
Treatment
This type of carcinoma is commonly managed by local resection, cryotherapy, topical chemotherapy, and radiotherapy. Multimodal therapy has been shown to improve both visual prognosis and survival.[3]
Mohs micrographic surgery has become the treatment of choice for this form of cancer. When used as the primary treatment modality for sebaceous carcinoma of the eyelid, Mohs surgery is associated with significantly lower local and distant recurrence rates.[4][8]
See also
- Sebaceous hyperplasia
- Sebaceous adenoma
- Sebaceoma
- List of cutaneous neoplasms associated with systemic syndromes
References
- ^ a b Nelson BR, Hamlet KR, Gillard M, Railan D, Johnson TM (July 1995). "Sebaceous carcinoma". J. Am. Acad. Dermatol. 33 (1): 1–15; quiz 16–8. doi:10.1016/0190-9622(95)90001-2. PMID 7601925.
- ^ a b c Rao NA, Hidayat AA, McLean IW, Zimmerman LE (February 1982). "Sebaceous carcinomas of the ocular adnexa: A clinicopathologic study of 104 cases, with five-year follow-up data". Hum. Pathol. 13 (2): 113–22. doi:10.1016/S0046-8177(82)80115-9. PMID 7076199.
- ^ a b Shields JA, Demirci H, Marr BP, Eagle RC, Shields CL (2005). "Sebaceous carcinoma of the ocular region: a review". Surv Ophthalmol 50 (2): 103–22. doi:10.1016/j.survophthal.2004.12.008. PMID 15749305.
- ^ a b Callahan EF, Appert DL, Roenigk RK, Bartley GB (August 2004). "Sebaceous carcinoma of the eyelid: a review of 14 cases". Dermatol Surg 30 (8): 1164–8. doi:10.1111/j.1524-4725.2004.30348.x. PMID 15274713.
- ^ Cohen PR (August 1992). "Sebaceous carcinomas of the ocular adnexa and the Muir-Torre syndrome". J. Am. Acad. Dermatol. 27 (2 Pt 1): 279–80. doi:10.1016/S0190-9622(08)80752-9. PMID 1430382.
- ^ Rishi K, Font RL (January 2004). "Sebaceous gland tumors of the eyelids and conjunctiva in the Muir-Torre syndrome: a clinicopathologic study of five cases and literature review". Ophthal Plast Reconstr Surg 20 (1): 31–6. doi:10.1097/01.IOP.0000103009.79852.BD. PMID 14752307.
- ^ Kumar V, Abbas AK, Fausto N. Robbins and Cotran Pathologic Basis of Disease. Seventh Edition. Philadelphia: Elsevier Saunders, 2005, p. 1425.
- ^ Spencer JM, Nossa R, Tse DT, Sequeira M (June 2001). "Sebaceous carcinoma of the eyelid treated with Mohs micrographic surgery". J. Am. Acad. Dermatol. 44 (6): 1004–9. doi:10.1067/mjd.2001.113692. PMID 11369914.
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Tumors: Skin neoplasm, skin appendages / Adnexal and skin appendage (C44.L40–L68/D23.L15–49, 173/216)
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| Glands |
| Sweat gland |
| Eccrine: |
- Papillary eccrine adenoma
- Eccrine carcinoma
- Eccrine nevus
- Syringofibroadenoma
- Spiradenoma
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| Apocrine: |
- Cylindroma
- Syringocystadenoma papilliferum
- Papillary hidradenoma
- Hidrocystoma
- Apocrine gland carcinoma
- Apocrine nevus
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| Eccrine/apocrine: |
- Syringoma
- Acrospiroma
- Hidradenoma/Hidradenocarcinoma
- Ceruminous adenoma
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| Sebaceous gland |
- Nevus sebaceous
- Muir–Torre syndrome
- Sebaceous carcinoma
- Sebaceous adenoma
- Sebaceoma
- Sebaceous nevus syndrome
- Sebaceous hyperplasia
- Mantleoma
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| Hair |
- Pilomatricoma/Malignant pilomatricoma
- Trichoepithelioma
- Multiple familial trichoepithelioma
- Solitary trichoepithelioma
- Desmoplastic trichoepithelioma
- Generalized trichoepithelioma
- Trichodiscoma
- Trichoblastoma
- Fibrofolliculoma
- Trichilemmoma
- Trichilemmal carcinoma
- Proliferating trichilemmal cyst
- Giant solitary trichoepithelioma
- Trichoadenoma
- Trichofolliculoma
- Dilated pore
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- Isthmicoma
- Fibrofolliculoma
- Perifollicular fibroma
- Birt–Hogg–Dubé syndrome
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| Hamartoma: |
- Basaloid follicular hamartoma
- Folliculosebaceous cystic hamartoma
- Folliculosebaceous-apocrine hamartoma
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| Nails |
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noco/cong/tumr, sysi/epon
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 脂腺癌 sebaceous carcinoma
- 2. ミュアト－ル症候群 muir torre syndrome
- 3. 眼瞼の病変 eyelid lesions
- 4. 皮膚付属器癌 cutaneous adnexal tumors
- 5. モース手術 mohs surgery
English Journal
- Expression of cell cycle regulatory proteins in eyelid sebaceous gland carcinoma: Low p27 expression predicts poor prognosis.
- Kim N, Kim JE, Choung HK, Lee MJ, Khwarg SI.SourceDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul, South Korea; Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, South Korea.
- Experimental eye research.Exp Eye Res.2013 Nov 8. pii: S0014-4835(13)00311-4. doi: 10.1016/j.exer.2013.10.022. [Epub ahead of print]
- Prognosis of eyelid sebaceous gland carcinoma is largely unpredictable and there are few practically available markers for predicting patients' prognosis. Dysregulation of cell cycle progression is strongly associated with the development of cancer and the cancer prognosis. We investigated the expre
- PMID 24216315
- Sebaceous carcinoma in Japanese patients: clinical presentation, staging and outcomes.
- Watanabe A, Sun MT, Pirbhai A, Ueda K, Katori N, Selva D.SourceDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, , Kyoto, Japan.
- The British journal of ophthalmology.Br J Ophthalmol.2013 Nov;97(11):1459-63. doi: 10.1136/bjophthalmol-2013-303758. Epub 2013 Sep 13.
- AIM: To describe the clinical features, management and correlation of the American Joint Committee on Cancer tumour node metastasis (TNM) staging for eyelid carcinoma with outcomes in Japanese patients with sebaceous carcinoma.METHODS: Multicentre retrospective review of 63 Japanese patients. Tumour
- PMID 24037608
- Downregulation of erythroid differentiation regulator 1 as a novel marker of skin tumors.
- Lee YB, Kim HJ, Jung HY, Park YG, Kim SY, Cho BK, Cho D, Park HJ.SourceDepartment of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- International journal of dermatology.Int J Dermatol.2013 Oct 29. doi: 10.1111/ijd.12057. [Epub ahead of print]
- BACKGROUND: Erythroid differentiation regulator 1 is decreased in malignant melanoma. However, the expression of erythroid differentiation regulator 1 has not been reported in normal epidermis, vessel, nerve, dermal adnexae, and various skin tumors.METHODS: To investigate the expression of erythroid
- PMID 24168163
Japanese Journal
- 症例 脂腺母斑からの発生が疑われた基底細胞癌と有棘細胞癌の併発例
Related Links
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