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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/25 23:54:03」(JST)

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Sclerotome

Scheme showing the manner in which each vertebral centrum is developed from portions of two adjacent segments.

Transverse section of a human embryo of the third week to show the differentiation of the primitive segment. (Kollmann.) ao. Aorta. m.p. Muscle-plate. n.c. Neural canal. sc. Sclerotome. s.p. cutis-plate.
Latin	sclerotomus
Gray's	subject #17 80
Carnegie stage	10
Precursor	somite
Gives rise to	vertebrae
Code	TE E5.0.2.2.2.0.1

A sclerotome is part of a somite, a structure in vertebrate embryonic development. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra.^[1]

From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch. Other cells move distally to the costal processes of thoracic vertebrae to form the ribs.^[1]

References

^ ^a ^b Walker, Warren F., Jr. (1987) Functional Anatomy of the Vertebrate San Francisco: Saunders College Publishing.

External links

mslimb-008 — Embryo Images at University of North Carolina
Diagrams at ciwemb.edu
Embryology at UNSW Notes/week3_6

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English Journal

Extracellular matrix assembly and 3D organization during paraxial mesoderm development in the chick embryo.

Rifes P, Thorsteinsdóttir S.SourceCentro de Biologia Ambiental/Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal; Instituto Gulbenkian de Ciência, Oeiras, Portugal.
Developmental biology.Dev Biol.2012 Jun 13. [Epub ahead of print]
The extracellular matrix (ECM) is a major player in the microenvironment governing morphogenesis. However, much is yet to be known about how matrix composition and architecture changes as it influences major morphogenetic events. Here we performed a detailed, 3D analysis of the distribution of two E
PMID 22705477

The generation of vertebral segmental patterning in the chick embryo.

Senthinathan B, Sousa C, Tannahill D, Keynes R.SourceDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Journal of anatomy.J Anat.2012 Jun;220(6):591-602. doi: 10.1111/j.1469-7580.2012.01497.x. Epub 2012 Mar 28.
We have carried out a series of experimental manipulations in the chick embryo to assess whether the notochord, neural tube and spinal nerves influence segmental patterning of the vertebral column. Using Pax1 expression in the somite-derived sclerotomes as a marker for segmentation of the developing
PMID 22458512

Japanese Journal

Investigation of mRNA Expression for Secreted Frizzled-Related Protein 2 (sFRP2) in Chick Embryos

LIN Chung-Tien,LIN Yu-Ting,KUO Tzong-Fu
The Journal of reproduction and development 53(4), 801-810, 2007-08-01
… In younger embryos on days 3-6, the sFRP2 signals were consistent with growth of the sclerotome, suggesting that sFRP2 may be associated with somite development. …
NAID 10020003842