WordNet

a skin disease marked by hard edema of the tissue usually beginning in the face

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/19 09:46:31」(JST)

wiki en

Scleredema, also known as Buschke disease, scleredema of Buschke, and scleredema adultorum,^[1]^[2] is a rare, self-limiting skin condition defined by progressive thickening and hardening of the skin, usually on the areas of the upper back, neck, shoulders and face.^[3] The skin may also change color to red or orange. The disease was discovered by Abraham Buschke. Although the cause of scleredema is unknown, it is usually associated with a disease, usually diabetes,^[4] a viral illness or strep throat.^[5] It is usually not fatal, but it may cause death if the disease spreads to the internal organs.^[3] It may also cause an infection.^[5]

Diagnosis

The scleredema is usually proposed as a diagnosis based on the appearance of the skin and the patient's medical history. To confirm the diagnosis, the doctor performs a skin biopsy, in which hematoxylin and eosin staining will show a thick reticular dermis with thick collagen bundles separated by clear spaces.^[6] The patient's blood may be examined for diseases that may appear after the onset of symptoms, such as multiple myeloma.^[5]

Treatment

Although many types of medications have been tried as treatments, none of them have been proven effective in treating scleredema. Those treatments, such as corticosteroids, may benefit the patient, but will not cure their condition. If the affected area is infected, it is usually treated immediately. The symptoms of the condition usually resolve within six months to two years after onset. However, patients whose condition was associated to diabetes may suffer for longer periods of time.^[5]

Myocarditis resulting as a complication from the disease has been successfully treated with penicillin and steroids.^[7]

References

^ Turchin I, Adams SP, Enta T (September 2003). "Dermacase. Scleredema adultorum, or Bushke disease". Can Fam Physician 49: 1089, 1093. PMC 2214291. PMID 14526859.
^ Pegum JS (June 1972). "Scleredema of Buschke". Proc. R. Soc. Med. 65 (6): 528. PMC 1643957. PMID 5044976.
^ ^a ^b "Scleredema". Retrieved 2009-05-18.
^ Meguerditchian, C; Jacquet P, Béliard S et al. (November 2006). "Scleredema adultorum of Buschke: an under recognized skin complication of diabetes". Diabetes and Metabolism 32 (5): 481–484. doi:10.1016/S1262-3636(07)70307-5. PMID 17110904.
^ ^a ^b ^c ^d "Scleredema". Retrieved 2009-05-18.
^ Schmults CA (October 2003). "Scleredema". Dermatol. Online J. 9 (4): 11. PMID 14594584.
^ "Buschke's Sclerema with right-sided heart failure.". Retrieved 2009-05-18.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 浮腫性硬化症 scleredema
2. 硬化性粘液水腫 scleromyxedema
3. 内臓悪性腫瘍の皮膚症状 cutaneous manifestations of internal malignancy
4. 好酸球性筋膜炎 eosinophilic fasciitis
5. 成人における全身性硬化症（強皮症）の診断および鑑別診断 diagnosis and differential diagnosis of systemic sclerosis scleroderma in adults

English Journal

Neck Pain, Stiffness, and Periorbital Edema in a Man With Diabetes.

Chatterjee S1.
JAMA.JAMA.2016 Mar 15;315(11):1159-60. doi: 10.1001/jama.2016.1770.
PMID 26978211

A case of scleredema adultorum successfully treated with narrow-band ultraviolet B phototherapy.

Yoshimura J1, Asano Y1, Takahashi T1, Uwajima Y1, Kagami S1, Honda H2, Idezuki T2, Igarashi A2, Sato S1.
Modern rheumatology / the Japan Rheumatism Association.Mod Rheumatol.2016 Mar;26(2):302-6. doi: 10.3109/14397595.2013.875640. Epub 2014 Feb 5.
Scleredema adultorum, also known as scleredema of Buschke, is a rare connective tissue disease with unknown etiology, which is characterized by diffuse skin induration of face, neck, upper chest, back, shoulders and arms. Although there is no established treatment for this disease, the efficacy of p
PMID 24499427

Scleredema adultorum of Buschke with prominent periorbital edema in a Tunisian patient with diabetes mellitus: a case report.

Mohamed M1, Belhadjali H1, Béchir AB1, Moussa A2, Zili J1.
International journal of dermatology.Int J Dermatol.2016 Feb;55(2):e100-2. doi: 10.1111/ijd.13128. Epub 2015 Nov 4.
PMID 26536602

Japanese Journal

Scleredema adultorum treated with narrow-band ultraviolet B phototherapy

XIAO Ting,YANG Zhen-Hai,HE Chun-Di,CHEN Hong-Duo
Journal of dermatology 34(4), 270-272, 2007-04-01
NAID 10020116214

Successful UVA1 phototherapy in a patient with scleredema adultorum

EBERLEIN-KONIG B
J Eur Acad Dermatol Venereol 19, 203-204, 2005
NAID 30010612483

Scleredema adultorum due to streptococcal infection

ALP HANDAN,ORBAK ZERRIN,AKTAS AKIN
Pediatrics international : official journal of the Japan Pediatric Society 45(1), 101-103, 2003-02-01
NAID 10011916778