WordNet

want to have; "Id like a beer now!"
a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
be fond of; "I like my nephews"
feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
(medicine) any sensation or change in bodily function that is experienced by a patient and is associated with a particular disease
anything that accompanies X and is regarded as an indication of Xs existence
any of several psychotic disorders characterized by distortions of reality and disturbances of thought and language and withdrawal from social contact (同)schizophrenic_disorder, schizophrenic psychosis, dementia_praecox
a feeling of pleasure and enjoyment; "Ive always had a liking for reading"; "she developed a liking for gin"
found pleasant or attractive; often used as a combining form; "a well-liked teacher"

PrepTutorEJDIC

…‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
(外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
(病気の)徴候,症状《+of+名》 / (一般)に(…の)徴候,きざし,印《+of+名》
精神分裂症
(…の)『好み』,趣味《+『for』(『to』)+『名』》

UpToDate Contents

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1. 統合失調症：臨床症状、経過、評価、および診断 schizophrenia clinical manifestations course assessment and diagnosis
2. 統合失調症における不安 anxiety in schizophrenia
3. 統合失調症：疫学および病因 schizophrenia epidemiology and pathogenesis
4. Evaluation and management of treatment-resistant schizophrenia
5. 統合失調症におけるうつ病 depression in schizophrenia

English Journal

Alterations of miR-132 are novel diagnostic biomarkers in peripheral blood of schizophrenia patients.

Yu HC1, Wu J2, Zhang HX3, Zhang GL4, Sui J4, Tong WW4, Zhang XY4, Nie LL5, Duan JH4, Zhang LR6, Lv LX7.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2015 Dec 3;63:23-9. doi: 10.1016/j.pnpbp.2015.05.007. Epub 2015 May 16.
Alterations in microRNAs (miRNAs) have been considered to have diagnostic implications in most diseases, but few studies have reported dysregulated miRNAs in schizophrenia (SCZ). In order to observe an association between miRNAs and SCZ, this study was designed to investigate expression profiling of
PMID 25985888

Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor.

Pompeu TE1, Monteiro do Monte F1, Bosier B2, Fraga CA3, Barreiro EJ3, Menegatti R4, Hermans E2, Noël F5.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2015 Oct 1;62:1-6. doi: 10.1016/j.pnpbp.2015.04.003. Epub 2015 Apr 17.
In an attempt to better understand the molecular mechanism of action of the antipsychotic lead LASSBio-579 and of its main metabolite LQFM 037, the aim of this work was to evaluate their intrinsic activity and binding kinetics at the dopamine D2 receptor. In transfected HEK cells expressing the D2L
PMID 25891249

mGlu5-GABAB interplay in animal models of positive, negative and cognitive symptoms of schizophrenia.

Wierońska JM1, Kłeczek N2, Woźniak M2, Gruca P2, Łasoń-Tyburkiewicz M2, Papp M2, Brański P2, Burnat G2, Pilc A3.
Neurochemistry international.Neurochem Int.2015 Sep;88:97-109. doi: 10.1016/j.neuint.2015.03.010. Epub 2015 Apr 8.
Diverse preclinical studies exploiting the modulation of the GABAergic and/or glutamatergic system in brain via metabotropic receptors suggest their potential therapeutic utility. GS39783 and CDPPB, positive allosteric modulators of GABAB and mGlu5 receptors, were previously shown to reverse behavio
PMID 25863284

Japanese Journal

前頭前皮質のプレシナプス・タンパク質Piccoloを発現抑制した統合失調症モデル動物における認知機能障害は、嗅周皮質の神経ネットワーク不全に関与する

宮本嘉明,桶谷祐貴,濱谷康平,村松慎一,新田淳美
日本薬理学会年会要旨集 93(0), 3-O-100, 2020
… Schizophrenia, a severe psychiatric disorder, exhibits three major symptoms, including cognitive dysfunction. … We previously proposed that mice knocking down Piccolo in the prefrontal cortex (PFC-Piccolo-KD mice) were useful as an animal model for schizophrenia based on those face and predictive validities. …
NAID 130007811808

マウス嗅周皮質におけるプレシナプスタンパク質Piccoloのノックダウンは認知機能障害を引き起こす

桶谷祐貴,宮本嘉明,濱谷康平,村松慎一,新田淳美
日本薬理学会年会要旨集 92(0), 1-P-027, 2019
… Schizophrenia is a severe mental disorder with cognitive dysfunction as one of the core symptoms. … gene serves at the nerve terminal, its knock down (KD) in mice prefrontal cortex (PFC) induced schizophrenia-like symptoms. …
NAID 130007812595

統合失調症治療薬ブレクスピプラゾール（レキサルティ錠® 1 mg，2 mg）の薬理学的特性と臨床効果

鈴木幹生,新留和成,前田健二,菊地哲朗,宇佐美智浩,二村隆史
日本薬理学雑誌 154(5), 275-287, 2019
ブレクスピプラゾール（レキサルティ®）は，大塚製薬がアリピプラゾールに続いて創製した，世界で2番目のドパミンD2受容体部分アゴニスト系の新規抗精神病薬である．本剤はセロトニン5-HT1A受容体及びD2</sub&gt …
NAID 130007745896