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English Journal

The proton pump inhibitor lansoprazole improves the skeletal phenotype in dystrophin deficient mdx mice.

Sali A1, Many GM, Gordish-Dressman H, van der Meulen JH, Phadke A, Spurney CF, Cnaan A, Hoffman EP, Nagaraju K.
PloS one.PLoS One.2013 Jul 2;8(7):e66617. doi: 10.1371/journal.pone.0066617. Print 2013.
BACKGROUND: In Duchenne muscular dystrophy (DMD), loss of the membrane stabilizing protein dystrophin results in myofiber damage. Microinjury to dystrophic myofibers also causes secondary imbalances in sarcolemmic ion permeability and resting membrane potential, which modifies excitation-contraction
PMID 23843959

Pan Y1, Chen C, Shen Y, Zhu CH, Wang G, Wang XC, Chen HQ, Zhu MS.
Molecules and cells.Mol Cells.2008 Jun 30;25(4):531-7. Epub 2008 May 6.
Abnormal activation of nuclear factor kappa B (NF-kappaB) probably plays an important role in the pathogenesis of Duchenne's muscular dystrophy (DMD). In this report, we evaluated the efficacy of curcumin, a potent NF-kappaB inhibitor, in mdx mice, a mouse model of DMD. We found that it improved sar
PMID 18460899

Adenosine prevents K+-induced Ca2+ loading: insight into cardioprotection during cardioplegia.

Jovanović A1, Lopez JR, Alekseev AE, Shen WK, Terzic A.
The Annals of thoracic surgery.Ann Thorac Surg.1998 Feb;65(2):586-91.
In clinical practice, hyperkalemic cardioplegia induces sarcolemmic depolarization, and therefore is used to arrest the heart during open heart operations. However, the elevated concentration of K+ that is present in cardioplegic solutions promotes intracellular Ca2+ loading, which could aggravate v
PMID 9485282