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TRPC1 protects dopaminergic SH-SY5Y cells from MPP+, salsolinol, and N-methyl-(R)-salsolinol-induced cytotoxicity.

Arshad A1, Chen X, Cong Z, Qing H, Deng Y.
Acta biochimica et biophysica Sinica.Acta Biochim Biophys Sin (Shanghai).2014 Jan;46(1):22-30. doi: 10.1093/abbs/gmt127. Epub 2013 Nov 18.
Neurotoxins and alterations in Ca2+ homeostasis have been associated with Parkinson's disease (PD), but the role of store-operated Ca2+ entry channels is not well understood. Previous studies have shown the neurotoxicity of salsolinol and 1-methyl-4-phenylpyridinium ion on SH-SY5Y cells and cytoprot
PMID 24252728

Synthesis of 1-substituted tetrahydroisoquinolines by lithiation and electrophilic quenching guided by in situ IR and NMR spectroscopy and application to the synthesis of salsolidine, carnegine and laudanosine.

Li X1, Leonori D, Sheikh NS, Coldham I.
Chemistry (Weinheim an der Bergstrasse, Germany).Chemistry.2013 Jun 10;19(24):7724-30. doi: 10.1002/chem.201301096. Epub 2013 May 15.
The lithiation of N-tert-butoxycarbonyl (N-Boc)-1,2,3,4-tetrahydroisoquinoline was optimized by in situ IR (ReactIR) spectroscopy. Optimum conditions were found by using n-butyllithium in THF at -50 °C for less than 5 min. The intermediate organolithium was quenched with electrophiles to give 1
PMID 23677770

Toxic effects of low alcohol and nicotine combinations in SH-SY5Y cells are apoptotically mediated.

Ramlochansingh C1, Taylor RE, Tizabi Y.
Neurotoxicity research.Neurotox Res.2011 Oct;20(3):263-9. doi: 10.1007/s12640-011-9239-x. Epub 2011 Jan 8.
It is well established that combination of heavy drinking and smoking has severe health consequences. However, at relatively low concentrations, both alcohol and nicotine may have beneficial effects including neuroprotection. Thus, protective effects of low alcohol concentration against beta-amyloid
PMID 21222065