rickettsial vaccine

WordNet

immunogen consisting of a suspension of weakened or dead pathogenic cells injected in order to stimulate the production of antibodies (同)vaccinum
any of a group of very small rod-shaped bacteria that live in biting arthropods (as ticks and mites) and cause disease in vertebrate hosts; they cause typhus and other febrile diseases in human beings
relating to or caused by rickettsias

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Full-genome sequence of human betacoronavirus 2c jordan-n3/2012 after serial passage in Mammalian cells.

Frey KG1, Redden CL, Bishop-Lilly KA, Johnson R2, Hensley LE2, Raviprakash K3, Luke T, Kochel T3, Mokashi VP4, Defang GN5.
Genome announcements.Genome Announc.2014 May 29;2(3). pii: e00324-14. doi: 10.1128/genomeA.00324-14.
Middle East respiratory syndrome coronavirus (MERS-CoV) is the etiologic agent of a highly lethal pneumonia. Here, we report the full-genome sequence of the Jordan-N3/2012 strain after serial passage in two distinct mammalian cell lines. The genome exhibits noteworthy stability, which may inform the
PMID 24874668

Surface protein Adr2 of Rickettsia rickettsii induced protective immunity against Rocky Mountain spotted fever in C3H/HeN mice.

Gong W1, Xiong X2, Qi Y1, Jiao J1, Duan C1, Wen B3.
Vaccine.Vaccine.2014 Apr 11;32(18):2027-33. doi: 10.1016/j.vaccine.2014.02.057. Epub 2014 Feb 28.
BACKGROUND: Rickettsia rickettsii is the pathogen of Rocky Mountain spotted fever (RMSF), a life-threatening tick-transmitted infection. Adr2 was a surface-exposed adhesion protein of R. rickettsii and its immunoprotection against RMSF was investigated in mice.METHODS: Recombinant Adr2 (rAdr2) was u
PMID 24582636

Immunogenicity of ALVAC-HIV vCP1521 in infants of HIV-1-infected women in Uganda (HPTN 027): the first pediatric HIV vaccine trial in Africa.

Kaleebu P1, Njai HF, Wang L, Jones N, Ssewanyana I, Richardson P, Kintu K, Emel L, Musoke P, Fowler MG, Ou SS, Jackson JB, Guay L, Andrew P, Baglyos L, Cao H; HPTN 027 protocol team.
Journal of acquired immune deficiency syndromes (1999).J Acquir Immune Defic Syndr.2014 Mar 1;65(3):268-77. doi: 10.1097/01.qai.0000435600.65845.31.
OBJECTIVE: Maternal-to-child-transmission of HIV-1 infection remains a significant cause of HIV-1 infection despite successful prevention strategies. Testing protective HIV-1 vaccines remains a critical priority. The immunogenicity of ALVAC-HIV vCP1521 (ALVAC) in infants born to HIV-1-infected women
PMID 24091694

Development of multiple-locus variable-number tandem-repeat analysis for rapid genotyping of Ehrlichia ruminantium and its application to infected Amblyomma variegatum collected in heartwater endemic areas in Uganda

Nakao Ryo,Morrison Liam J.,Zhou Lijia,Magona Joseph W.,Jongejan Frans,Sugimoto Chihiro
Parasitology 139(1), 69-82, 2012-01
… The rickettsial bacterium Ehrlichia ruminantium is the causative agent of heartwater, a serious tick-borne disease in ruminants. … The genetic diversity of organisms in the field will have implications for cross-protective capacities of any vaccine developed, and for an effective vaccine design strategy proper genotyping and understanding of existing genetic diversity in the field is necessary. …
NAID 120003837251

Multi-locus sequence typing of Ehrlichia ruminantium strains from geographically diverse origins and collected in Amblyomma variegatum from Uganda

Nakao Ryo,Magona Joseph W.,Zhou Lijia,Jongejan Frans,Sugimoto Chihiro
Parasites & Vectors 4, 137, 2011-07-15
… Background: The rickettsial bacterium Ehrlichia ruminantium is the causative agent of heartwater in ruminants. … Comprehensive information on the degree of cross-protection between strains and further understanding of possible relationships between genotypes and phenotypes such as vaccine efficacy are expected to lead to the development of region-specific vaccination strategies. …
NAID 120003260048