a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11
Reviparin is an antithrombotic and belongs to the group of low molecular weight heparins (LMWH).
Contents
1Medical uses
2Chemistry
3References
4External links
Medical uses
Prevention of blood clots
Prophylaxis of perioperative thromboembolism[1][2]
Treatment of DVT with or without pulmonary embolism (PE)[3]
Prophylaxis of acute thrombotic events after percutaneous transluminal coronary angioplasty (PTCA)[4][5]
Chemistry
Reviparin is a low molecular weight heparin obtained by nitrous acid depolymerization of heparin extracted from porcine intestinal mucosa. Its structure is characterized, for the most part, by a group of 2-O-sulfo-α-lidopyranosuronic acid. The average molecular weight is about 3900 daltons.
References
^Kakkar VV, Cohen AT, Mohamed MS (1996). "Patients at risk of venous thromboembolism--clinical results with reviparin". Thromb. Res. 81 (2 Suppl): S39–45. doi:10.1016/0049-3848(95)00228-6. PMID 8822126.
^Lassen MR, Backs S, Borris LC, Kaltoft-Sørenson M, Coff-Ganes H, Jeppesen E (1999). "Deep-vein thrombosis prophylaxis in orthopedic surgery: hip surgery". Semin. Thromb. Hemost. 25 Suppl 3: 79–82. PMID 10549720.
^Gore M, Kelkar P, Rege N, Ross C (October 2004). "Reviparin sodium clivarine: a review of its therapeutic use". J Indian Med Assoc. 102 (10): 589–90, 592. PMID 15887830.
^Preisack MB, Karsch KR (December 1993). "Experimental and early clinical experience with reviparin-sodium for prevention of restenosis after percutaneous transluminal coronary angioplasty". Blood Coagul. Fibrinolysis. 4 Suppl 1: S55–8, discussion S59–60. PMID 8180331.
^Karsch KR, Preisack MB, Baildon R, Eschenfelder V, Foley D, Garcia EJ, Kaltenbach M, Meisner C, Selbmann HK, Serruys PW, Shiu MF, Sujatta M, Bonan R (November 1996). "Low molecular weight heparin (reviparin) in percutaneous transluminal coronary angioplasty. Results of a randomized, double-blind, unfractionated heparin and placebo-controlled, multicenter trial (REDUCE trial). Reduction of Restenosis After PTCA, Early Administration of Reviparin in a Double-Blind Unfractionated Heparin and Placebo-Controlled Evaluation". J. Am. Coll. Cardiol. 28 (6): 1437–43. doi:10.1016/s0735-1097(96)00343-9. PMID 8917255.
External links
reviparin at the US National Library of Medicine Medical Subject Headings (MeSH)
Yusuf S, Mehta SR, Xie C, et al. (2005). "Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation". JAMA. 293 (4): 427–35. doi:10.1001/jama.293.4.427. PMID 15671427.
v
t
e
Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)
Repeated Oral or Subcutaneous LMWH Has similar Antithrombotic Activity in a Rat Venous Thrombosis Model: Antithrombotic Activity Correlates With Heparin on Endothelium When Orally Administered.
Hiebert LM1.
Journal of cardiovascular pharmacology and therapeutics.J Cardiovasc Pharmacol Ther.2016 Sep 20. pii: 1074248416667601. [Epub ahead of print]
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.Clin Appl Thromb Hemost.2014 Oct;20(7):678-86. doi: 10.1177/1076029614545212. Epub 2014 Aug 12.
Are pharmacological properties of anticoagulants reflected in pharmaceutical pricing and reimbursement policy? Out-patient treatment of venous thromboembolism and utilization of anticoagulants in Poland.
Bochenek T1, Czarnogorski M, Nizankowski R, Pilc A.
European review for medical and pharmacological sciences.Eur Rev Med Pharmacol Sci.2014 Jun;18(11):1649-56.
Reviparin Sodium is a medicine available in a number of countries worldwide. A list of US medications equivalent to Reviparin Sodium is available on the Drugs.com website. ... Drugs.com provides accurate and independent ...
1. Expert Opin Pharmacother. 2002 Feb;3(2):173-82. Reviparin sodium - a new low molecular weight heparin. Breddin HK(1). Author information: (1)International Institute of Thrombosis and Vascular Diseases e ...