WordNet
- of the transmission gear causing backward movement in a motor vehicle; "in reverse gear"
- a relation of direct opposition; "we thought Sue was older than Bill but just the reverse was true" (同)contrary, opposite
- the gears by which the motion of a machine can be reversed (同)reverse gear
- the side of a coin or medal that does not bear the principal design (同)verso
- (American football) a running play in which a back running in one direction hands the ball to a back running in the opposite direction
- an unfortunate happening that hinders or impedes; something that is thwarting or frustrating (同)reversal, setback, blow, black_eye
- tending to undergo or resulting from mutation; "a mutant gene"
- an animal that has undergone mutation
- (biology) an organism that has characteristics resulting from chromosomal alteration (同)mutation, variation, sport
- a lapel on a womans garment; turned back to show the reverse side (同)revere
- turned inside out and resewn; "the reversed collar looked as good as new"
PrepTutorEJDIC
- (位置・方向・順序などにおいて)『逆の』;裏側の』 / 逆に動かす(動く),バックの / 〈U〉《the reverse》(…の)『反対』,『逆』《+『of』+『名』(『wh』‐節)》》 / 〈U〉《the reverse》(貨幣・メダルなどの)『裏側』,(一般に)(…の)裏面《+『of』+『名』》 / 〈C〉(運命などの)逆転,不運 / 〈U〉後退[装置],逆転[装置] / …‘を'『逆にする』,反対にする;…‘を'裏返す / 〈機械など〉‘を'逆転させる,逆方向に動かす / 〈判決など〉‘を'取り消す,破棄する / (ダンスで)逆に回る / 〈機械などが〉逆方向に動く
- 突然変異種(堤)
- （フランス語）(えりの)裏出し,折り返し
- 逆にした,反対の,裏返のし;取り消された
UpToDate Contents
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- 1. ワルファリンに関係した脳出血における抗凝固療法の反転 reversal of anticoagulation in warfarin associated intracerebral hemorrhage
- 2. 精管切除の概要 overview of vasectomy
- 3. 麻酔後ケア病棟における合併症発生の概要 overview of complications occurring in the post anesthesia care unit
- 4. Therapeutic use of unfractionated heparin and low molecular weight heparin
- 5. 消化管内視鏡検査に対する鎮静の合併症 complications of procedural sedation for gastrointestinal endoscopy
English Journal
- Novel lipid droplet-associated serine hydrolase regulates macrophage cholesterol mobilization.
- Goo YH, Son SH, Kreienberg PB, Paul A.Author information From the Center for Cardiovascular Sciences, Albany Medical College, NY (Y.-H.G., S.-H.S., A.P.); and the Institute for Vascular Health and Disease, Albany, NY (P.B.K.).AbstractOBJECTIVE: Lipid-laden macrophages or foam cells are characterized by massive cytosolic lipid droplet (LD) deposition containing mostly cholesterol ester (CE) derived from the lipoproteins cleared from the arterial wall. Cholesterol efflux from foam cells is considered to be atheroprotective. Because cholesterol is effluxed as free cholesterol, CE accumulation in LDs may limit free cholesterol efflux. Our objective was to identify proteins that regulate cholesterol trafficking through LDs.
- Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2014 Feb;34(2):386-96. doi: 10.1161/ATVBAHA.113.302448. Epub 2013 Dec 19.
- OBJECTIVE: Lipid-laden macrophages or foam cells are characterized by massive cytosolic lipid droplet (LD) deposition containing mostly cholesterol ester (CE) derived from the lipoproteins cleared from the arterial wall. Cholesterol efflux from foam cells is considered to be atheroprotective. Becaus
- PMID 24357060
- Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.
- Allory Y1, Beukers W2, Sagrera A3, Flández M3, Marqués M3, Márquez M4, van der Keur KA2, Dyrskjot L5, Lurkin I2, Vermeij M2, Carrato A6, Lloreta J7, Lorente JA8, Carrillo-de Santa Pau E3, Masius RG2, Kogevinas M9, Steyerberg EW10, van Tilborg AA2, Abas C11, Orntoft TF5, Zuiverloon TC2, Malats N4, Zwarthoff EC2, Real FX12.Author information 1Epithelial Carcinogenesis Group, Molecular Pathology Program, CNIO (Spanish National Cancer Research Center), Madrid, Spain; Université Paris-Est Créteil, Institut Mondor de Recherche Biomédicale, Créteil, France.2Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.3Epithelial Carcinogenesis Group, Molecular Pathology Program, CNIO (Spanish National Cancer Research Center), Madrid, Spain.4Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, CNIO (Spanish National Cancer Research Center), Madrid, Spain.5Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.6Medical Oncology Department, Ramón y Cajal University Hospital, Madrid, Spain.7Department of Pathology, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.8Urology Service, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain.9Centre de Recerca d'Epidemiologia Ambiental, Barcelona, Spain; IMIM-Institut de Recerca Hospital del Mar, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; National School of Public Health, Athens, Greece.10Department of Public Health, Erasmus MC, Rotterdam, The Netherlands.11Department of Pathology, Erasmus MC, Rotterdam, The Netherlands; Epithelial Carcinogenesis Group, Molecular Pathology Program, CNIO (Spanish National Cancer Research Center), Madrid, Spain.12Epithelial Carcinogenesis Group, Molecular Pathology Program, CNIO (Spanish National Cancer Research Center), Madrid, Spain; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address: preal@cnio.es.AbstractBACKGROUND: Hotspot mutations in the promoter of the gene coding for telomerase reverse transcriptase (TERT) have been described and proposed to activate gene expression.
- European urology.Eur Urol.2014 Feb;65(2):360-6. doi: 10.1016/j.eururo.2013.08.052. Epub 2013 Sep 7.
- BACKGROUND: Hotspot mutations in the promoter of the gene coding for telomerase reverse transcriptase (TERT) have been described and proposed to activate gene expression.OBJECTIVES: To investigate TERT mutation frequency, spectrum, association with expression and clinical outcome, and potential for
- PMID 24018021
- Impact of Potential Permissive Neuraminidase Mutations on Viral Fitness of the H275Y Oseltamivir-Resistant Influenza A(H1N1)pdm09 Virus In Vitro, in Mice and in Ferrets.
- Abed Y, Pizzorno A, Bouhy X, Rhéaume C, Boivin G.Author information Research Center in Infectious Diseases of the CHUQ-CHUL and Laval University, Québec City, QC, Canada.AbstractNeuraminidase (NA) mutations conferring resistance to NA inhibitors (NAIs) generally compromise the fitness of influenza viruses. The only NAI-resistant virus that widely spread in the population, the A/Brisbane/59/2007 (H1N1) strain, contained permissive mutations that restored the detrimental effect caused by the H275Y change. Computational analysis predicted other permissive NA mutations for A(H1N1)pdm09 viruses. Here, we investigated the effect of T289M and N369K mutations on the viral fitness of the A(H1N1)pdm09 H275Y variant. Recombinant wild-type (WT) A(H1N1)pdm09 and the H275Y, H275Y/T289M, H275Y/N369K, and H275Y/V241I/N369K (a natural variant) NA mutants were generated by reverse genetics. Replication kinetics were performed by using ST6GalI-MDCK cells. Virulence was assessed in C57BL/6 mice, and contact transmission was evaluated in ferrets. The H275Y mutation significantly reduced viral titers during the first 12 to 36 h postinfection (p.i.) in vitro. Nevertheless, the WT and H275Y viruses induced comparable mortality rates, weight loss, and lung titers in mice. The T289M mutation eliminated the detrimental effect caused by the H275Y change in vitro while causing greater weight loss and mortality in mice, with significantly higher lung viral titers on days 3 and 6 p.i. than with the H275Y mutant. In index ferrets, the WT, H275Y, H275Y/T289M, and H275Y/V241I/N369K recombinants induced comparable fever, weight loss, and nasal wash viral titers. All tested viruses were transmitted at comparable rates in contact ferrets, with the H275Y/V241I/N369K recombinant demonstrating higher nasal wash viral titers than the H275Y mutant. Permissive mutations may enhance the fitness of A(H1N1)pdm09 H275Y viruses in vitro and in vivo. The emergence of such variants should be carefully monitored.
- Journal of virology.J Virol.2014 Feb;88(3):1652-8. doi: 10.1128/JVI.02681-13. Epub 2013 Nov 20.
- Neuraminidase (NA) mutations conferring resistance to NA inhibitors (NAIs) generally compromise the fitness of influenza viruses. The only NAI-resistant virus that widely spread in the population, the A/Brisbane/59/2007 (H1N1) strain, contained permissive mutations that restored the detrimental effe
- PMID 24257597
Japanese Journal
- Detection of the staphylococcal enterotoxin D-like gene from staphylococcal food poisoning isolates over the last two decades in Tokyo
- SUZUKI Yasunori,KOBAYASHI Makiko,MATSUSHITA Shigeru,UEHARA Satomi,KATO Rei,SATO'O Yusuke,ONO Hisaya K.,SADAMASU Kenji,KAI Akemi,KAMATA Yoichi
- Journal of Veterinary Medical Science 77(8), 905-911, 2015
- … A nucleotide sequencing analysis revealed that three plasmids harbored by the SED-non-producing isolates had a single-base deletion in the sed gene with a resulting stop codon (from 233 amino acids of the intact SED to 154 amino acids of the mutant SED (mSED)). … A real-time reverse transcription-PCR analysis showed that the mRNA of the msed gene was transcribed in the isolates. …
- NAID 130005094680
- Detection of the staphylococcal enterotoxin D-like gene from staphylococcal food poisoning isolates over the last two decades in Tokyo
- SUZUKI Yasunori,KOBAYASHI Makiko,MATSUSHITA Shigeru,UEHARA Satomi,KATO Rei,SATO'O Yusuke,ONO Hisaya K.,SADAMASU Kenji,KAI Akemi,KAMATA Yoichi
- Journal of Veterinary Medical Science advpub(0), 2015
- … A nucleotide sequencing analysis revealed that three plasmids harbored by the SED-non-producing isolates had a single-base deletion in the sed gene with a resulting stop codon (from 233 amino acids of the intact SED to 154 amino acids of the mutant SED (mSED)). … A real-time reverse transcription-PCR analysis showed that the mRNA of the msed gene was transcribed in the isolates. …
- NAID 130004781135
- Amino acid substitutions away from the RNase H catalytic site increase the thermal stability of Moloney murine leukemia virus reverse transcriptase through RNase H inactivation.
- Konishi Atsushi,Hisayoshi Tetsuro,Yokokawa Kanta,Barrioluengo Verónica,Menéndez-Arias Luis,Yasukawa Kiyoshi
- Biochemical and biophysical research communications 454(2), 269-274, 2014-11-14
- … Lys) in the nucleic acid binding cleft of the Moloney murine leukemia virus reverse transcriptase (MMLV RT) in order to increase its template-primer (T/P) binding affinity. … The three single-mutants (E286R, E302K, and L435R), an RNase H-deficient MMLV RT (carrying the RNase H-inactivating mutation D524A), a quadruple mutant (E286R/E302K/L435R/D524A, designated as MM4) and the wild-type enzyme (WT) were produced in Escherichia coli. …
- NAID 120005522512
Related Links
- 必应词典为您提供reverse mutant的释义，un. 逆转突变种； 网络释义： 回复变株； ... reverse mutant
- 必应词典为您提供reversemutant的释义，un. 逆转突变种； 网络释义： 回复变株； ... reverse mutant
Related Pictures
★リンクテーブル★
| リンク元 | 「revertant」「復帰変異体」「復帰突然変異体」 |
| 関連記事 | 「reverse」「mutant」 |
「revertant」
「復帰変異体」
「復帰突然変異体」
「reverse」
- v.
- 逆転させる、逆行する、逆戻りさせる、リバースする
- adj.
- 逆の、逆性の
「mutant」
- n.