retinol O-fatty-acyltransferase

レチノール-O-脂肪酸アシル基転移酵素、レチノール-O-脂肪酸アシルトランスフェラーゼ

WordNet

1. having an (over)abundance of flesh; "he hadnt remembered how fat she was"
2. a soft greasy substance occurring in organic tissue and consisting of a mixture of lipids (mostly triglycerides); "pizza has too much fat"
3. marked by great fruitfulness; "fertile farmland"; "a fat land"; "a productive vineyard"; "rich soil" (同)fertile, productive, rich
4. lucrative; "a juicy contract"; "a nice fat job" (同)juicy
5. having a relatively large diameter; "a fat rope"
6. the 15th letter of the Roman alphabet (同)o
7. the blood group whose red cells carry neither the A nor B antigens; "people with type O blood are universal donors" (同)type_O, group O
8. containing or composed of fat; "fatty food"; "fat tissue" (同)fat

PrepTutorEJDIC

1. 『脂肪』,脂肪分 / (動物の)あぶら身 / (料理用の)油,ヘット / 肥満,太り過ぎ / 『太った』,肥満した / 『脂肪の多い』 / たっぷりとはいった,分厚い / もうかる / (土地が)肥えた / …‘を'太らせる / ふとる,肥える
2. 《呼び掛けの名前の前につけて》『おお』,あ / (驚き・恐れ・喜び・苦痛などを表して)『おお』,ああ,まあ / 《肯定・否定を強めて》
3. oxygenの化学記号
4. ohmオーム / Old
5. 脂肪質の,脂肪の多い / でぶ,太っちょ
6. osmiumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/30 10:10:40」(JST)

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[Wiki en表示]

retinol O-fatty-acyltransferase
Identifiers
EC number	2.3.1.76
CAS number	81295-48-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a retinol O-fatty-acyltransferase (EC 2.3.1.76) is an enzyme that catalyzes the chemical reaction

acyl-CoA + retinol CoA + retinyl ester

Thus, the two substrates of this enzyme are acyl-CoA and retinol, whereas its two products are CoA and retinyl ester.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:retinol O-acyltransferase. Other names in common use include retinol acyltransferase, and retinol fatty-acyltransferase. This enzyme participates in retinol metabolism.

References

• Helgerud P, Petersen LB, Norum KR (1983). "Retinol esterification by microsomes from the mucosa of human small intestine. Evidence for acyl-Coenzyme A retinol acyltransferase activity". J. Clin. Invest. 71 (3): 747–53. doi:10.1172/JCI110822. PMC 436925. PMID 6826734. 
• Ross AC (1982). "Retinol esterification by rat liver microsomes. Evidence for a fatty acyl coenzyme A: retinol acyltransferase". J. Biol. Chem. 257 (5): 2453–9. PMID 7061433. 

UpToDate Contents

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English Journal

• Identification of the 11-cis-specific retinyl-ester synthase in retinal Müller cells as multifunctional O-acyltransferase (MFAT).

• Kaylor JJ1, Cook JD1, Makshanoff J1, Bischoff N1, Yong J1, Travis GH2.
• Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2014 May 20;111(20):7302-7. doi: 10.1073/pnas.1319142111. Epub 2014 May 5.
• Absorption of a photon by a rhodopsin or cone-opsin pigment isomerizes its 11-cis-retinaldehyde (11-cis-RAL) chromophore to all-trans-retinaldehyde (all-trans-RAL), which dissociates after a brief period of activation. Light sensitivity is restored to the resulting apo-opsin when it recombines with
• PMID 24799687

• Genetic dissection of retinoid esterification and accumulation in the liver and adipose tissue.

• Wongsiriroj N1, Jiang H, Piantedosi R, Yang KJ, Kluwe J, Schwabe RF, Ginsberg H, Goldberg IJ, Blaner WS.
• Journal of lipid research.J Lipid Res.2014 Jan;55(1):104-14. doi: 10.1194/jlr.M043844. Epub 2013 Nov 1.
• Approximately 80-90% of all retinoids in the body are stored as retinyl esters (REs) in the liver. Adipose tissue also contributes significantly to RE storage. The present studies, employing genetic and nutritional interventions, explored factors that are responsible for regulating RE accumulation i
• PMID 24186946

• Cultured Müller cells from mammals can synthesize and accumulate retinyl esters.

• Betts BS, Obregon I, Tsin AT.
• Experimental eye research.Exp Eye Res.2012 Aug;101:56-9. doi: 10.1016/j.exer.2012.05.004. Epub 2012 May 24.
• PMID 22634428

Related Links

• Retinol O-fatty-acyltransferase - Springer

EC number 2.3.1.76 Systematic name acyl-CoA:retinol O-acyltransferase Recommended name retinol O-fatty-a ... Jurukovski, V.; Simon, M.: Reduced lecithin:retinol acyl transferase activity in cultured squamous cell carcinoma lines ...

• GO:0050252 retinol O-fatty-acyltransferase activity

The European Bioinformatics Institute ... Database Code Database Name UniProtKB Universal Protein Knowledgebase UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot UniProtKB/TrEMBL UniProtKB-TrEMBL protein sequence database

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★リンクテーブル★

リンク元	「レチノール-O-脂肪酸アシル基転移酵素」「レチノール-O-脂肪酸アシルトランスフェラーゼ」
関連記事	「acyltransferase」「fatty」「O」「fat」「Os」

「レチノール-O-脂肪酸アシル基転移酵素」

　　[★]

英

retinol O-fatty-acyltransferase

関

レチノール-O-脂肪酸アシルトランスフェラーゼ

「レチノール-O-脂肪酸アシルトランスフェラーゼ」

　　[★]

英

retinol O-fatty-acyltransferase

関

レチノール-O-脂肪酸アシル基転移酵素

「acyltransferase」

　　[★]

アシルトランスフェラーゼ、アシル転移酵素、アシル基転移酵素

関

transacylase

「fatty」

　　[★]

• adj.

• 脂肪性の、脂肪質の

関

adipose、aliphatic、lipogenous

　 　

「O」

　　[★]

同

食道入口部

　 　 　 　 　

「fat」

　　[★] 脂肪

　 　 　 　 　 　

「Os」

　　[★] オスミウム osmium