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1. 造血および幹細胞の機能の概要 overview of hematopoiesis and stem cell function
2. 悪性神経膠腫の病因と分子生物学 pathology and molecular pathogenesis of diffuse gliomas
3. 慢性骨髄性白血病の細胞生物学および分子生物学 cellular and molecular biology of chronic myeloid leukemia

English Journal

Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors.

Li Y1, Luo S1, Ma R1, Liu J1, Xu P1, Zhang H2, Tang K2, Ma J2, Zhang Y2, Liang X2, Sun Y1, Ji T1, Wang N3, Huang B4.
Cancer research.Cancer Res.2015 Apr 1;75(7):1191-1196. Epub 2015 Feb 24.
Although metabolic defects have been investigated extensively in differentiated tumor cells, much less attention has been directed to the metabolic properties of stem-like cells that repopulate tumors [tumor-repopulating cells (TRC)]. Here, we show that melanoma TRCs cultured in three-dimensional so
PMID 25712344

Regulatory T cells in B-cell-deficient and wild-type mice differ functionally and in expression of cell surface markers.

Ellis JS1, Braley-Mullen H.
Immunology.Immunology.2015 Apr;144(4):598-610. doi: 10.1111/imm.12410.
NOD.H-2h4 mice develop spontaneous autoimmune thyroiditis (SAT) with chronic inflammation of thyroids by T and B cells. B-cell deficient (B(-/-) ) mice are resistant to SAT but develop SAT if regulatory T (Treg) cells are transiently depleted. We established a transfer model using splenocytes from C
PMID 25318356

EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival.

Fu NY1, Rios AC1, Pal B1, Soetanto R2, Lun AT3, Liu K1, Beck T1, Best SA1, Vaillant F1, Bouillet P4, Strasser A4, Preiss T5, Smyth GK6, Lindeman GJ7, Visvader JE1.
Nature cell biology.Nat Cell Biol.2015 Apr;17(4):365-75. doi: 10.1038/ncb3117. Epub 2015 Mar 2.
Expansion and remodelling of the mammary epithelium requires a tight balance between cellular proliferation, differentiation and death. To explore cell survival versus cell death decisions in this organ, we deleted the pro-survival gene Mcl-1 in the mammary epithelium. Mcl-1 was found to be essentia
PMID 25730472

Acquired Radioresistance of Cancer and the AKT/GSK3β/cyclin D1 Overexpression Cycle

Shimura Tsutomu
Journal of radiation research 52(5), 539-544, 2011-09-16
… In fact, repopulating tumors often acquire radioresistance and this is the major cause of failure of RT. …
NAID 10029455512