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| Relapsing polychondritis | |
|---|---|
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Ear inflammation with sparing of ear lobe in a person with relapsing polychondritis[1]
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| Classification and external resources | |
| Specialty | rheumatology |
| ICD-10 | M94.1 |
| ICD-9-CM | 733.99 |
| DiseasesDB | 10248 |
| eMedicine | med/2000 derm/375 |
| Patient UK | Relapsing polychondritis |
| MeSH | D011081 |
Relapsing polychondritis, also known as atrophic polychondritis,[2] systemic chondromalacia[2]) chronic atrophic polychondritis, Meyenburg-Altherr-Uehlinger syndrome, and generalized chondromalacia, is a multi-systemic condition characterized by inflammation and deterioration of cartilage. The often painful disease can cause joint deformity and be life-threatening if the respiratory tract, heart valves or blood vessels are affected. The exact mechanism is poorly understood, but it is thought to be related to an immune-mediated attack on particular proteins that are abundant in cartilage.
The diagnosis is reached on the basis of the symptoms and supported by investigations such as blood tests and sometimes other investigations. Treatment may involve symptomatic treatment with painkillers or anti-inflammatory medications, and more severe cases may require suppression of the immune system.
Contents
- 1 Signs and symptoms
- 1.1 Cartilage inflammation
- 1.1.1 Ear
- 1.1.2 Nose
- 1.1.3 Respiratory tract
- 1.1.4 Ribs
- 1.2 Other manifestations
- 1.2.1 Joint
- 1.2.2 Eye
- 1.2.3 Neurological
- 1.2.4 Kidney
- 1.2.5 Constitutional symptoms
- 1.2.6 Others
- 1.1 Cartilage inflammation
- 2 Causes
- 3 Diagnosis
- 3.1 Diagnostic criteria
- 3.2 Laboratory findings
- 3.3 Imaging studies
- 3.4 Special tests
- 3.4.1 Biopsy
- 3.4.2 Pulmonary function tests
- 3.5 Associated diseases
- 3.6 Differential diagnosis
- 4 Treatment
- 5 Prognosis
- 6 Epidemiology
- 7 History
- 8 Research
- 9 References
- 10 External links
Signs and symptoms
Though any cartilage in the body may be affected in persons with relapsing polychondritis, in many cases the disease affects several areas while sparing others. The disease may be variable in its signs and symptoms, resulting in a difficult diagnosis which may leads to delayed recognition for several months, years or decades.[3] Joint symptoms are often one of the first signs of the disease with cartilage inflammation initially absent in nearly half the cases.[3]
Cartilage inflammation
Cartilage inflammation (technically known as chondritis) that is relapsing is very characteristic of the disease and is required for the diagnosis of RP.[3] These recurrent episodes of inflammation over the course of the disease may result in breakdown and loss of cartilage.[3] The signs and symptoms of cartilage inflammation in various parts of the body will be described first.
Ear
A cauliflower ear deformity
Inflammation of the cartilage of the ear is a specific symptom of the disease and affects most people.[3] It is present in about 20% of persons with RP at presentation and in 90% at some point.[3] Both ears are often affected but the inflammation may alternate between either ear during a relapse.[3] It is characteristic for the entire outer part of the ear except the earlobe to be swollen, red, or less often purplish, warm and painful to light touch.[3]
The inflammation of the ear usually lasts a few days or more, rarely a few weeks, and then resolves spontaneously and recurs at various intervals.[3] Because of the loss of cartilage, after several flares cauliflower ear deformity may result.[3] The outer part of the ear may be either floppy or hardened by calcifications of the scar tissue that replaces the cartilage.[3] These cauliflower ear deformities occurs in about 10% of persons with RP.[3]
Nose
The inflammation of the cartilage of the nose involves the bridge of the nose and is often less marked as the ears.[3] Statistics show that this clinical manifestation is present in 15% of persons with RP and occurs at some point in 65% of persons with RP.[3] Nasal obstruction is not a common feature.[3] Atrophy may eventually develop secondarily during the disease, this appears gradual and is not easily noticed.[3] This can result in collapse of the nasal septum with saddle-nose deformity, which is painless but irreversible.[3]
Respiratory tract
Inflammation occurs in the laryngeal, tracheal and bronchial cartilages.[4] Both of these sites are involved in 10% of persons with RP at presentation and 50% over the course of this autoimmune disease, and is more common among females.[3] The involvement of the laryngotracheobronchial cartilages may be severe and life-threatening; it causes one-third of all deaths among persons with RP.[3][5] Laryngeal chondritis is manifested as pain above the thyroid gland and, more importantly, as dysphonia with a hoarse voice or transient aphonia.[3] Because this disease is relapsing, recurrent laryngeal inflammation may result in laryngomalacia or permanent laryngeal stenosis with inspiratory dyspnea that may require emergency tracheotomy as a temporary or permanent measure.[3]
Tracheobronchial involvement may or may not be accompanied with laryngeal chondritis and is potentially the most severe manifestation of RP.
The symptoms consist of dyspnea, wheezing, a nonproductive cough, and recurrent, sometimes severe, lower respiratory tract infections.[3][5] Obstructive respiratory failure may develop as the result of either permanent tracheal or bronchial narrowing or chondromalacia with expiratory collapse of the tracheobronchial tree.[3] Endoscopy, intubation, or tracheotomy has been shown to hasten death.[3]
Ribs
Involvement of the rib cartilages results in costochondritis.[3] Symptoms include chest wall pain or, less often, swelling of the involved cartilage.[3] The involvement of the ribs is seen in 35% of persons with RP but is rarely the first symptom.[3]
Other manifestations
Relapsing polychondritis may affect many different organ systems of the body. At first, some people with the disease may have only nonspecific symptoms such as fever, weight loss, and malaise.[6]
Joint
The second most common clinical finding of this disease is joint pain with or without arthritis, after chondritis.[3][4] All synovial joints may be affected.[4][5]
At presentation, around 33% of people have joint symptoms that involve Polyarthralgia and/or polyarthritis or oligoarthritis that affects various parts of the body and often appears to be episodic, asymmetric, migratory and non-deforming.[5] The most common sites of involvement are the metacarpophalangeal joints, proximal interphalangeal joints and knees. After which is followed by the ankles, wrists, metatarsophalangeal joints and the elbows.[3] Any involvement of the axial skeleton is considered to be very rare.[3] Tests for rheumatoid factor are negative in affected persons with RP, unless there is a co-morbidity with RA.[4]
Less often it has been reported that persons may experience arthralgia, monoarthritis, or chronic polyarthritis that mimics rheumatoid arthritis, leading to a difficult diagnosis for this disease.[3] The appearance of erosions and destruction, however, is exceedingly rare and this may point instead to rheumatoid arthritis as a cause.[3]
Diseases and inflammation of tendons have been reported in small numbers of people with RP.[3] During the course of the disease, around 80% of people develop joint symptoms.[3]
Eye
Involvement of the eye is rarely the initial symptom but develops in 60% of persons with RP.[3][4][5][7][8]
The most common forms of ocular involvement are usually mild and often consist of unilateral or bilateral episcleritis and/or scleritis, that is often anterior and could be lingering or relapsing.[3][5] Scleritis that is necrotizing is found to be exceedingly rare.[3] Less often, conjunctivitis occurs.[3][5] There are also other ocular manifestations that occur in persons with RP, these include keratoconjunctivitis sicca, peripheral keratitis (rarely with ulcerations), anterior uveitis, retinal vasculitis, proptosis, lid edema, keratoconus, retinopathy, iridocyclitis and ischemic optic neuritis that can lead to blindness.[3][4][5][9] Cataract also is reported in relation to either the disease or to glucocorticoid exposure.[3]
Neurological
The involvement of the peripheral or central nervous system is relatively rare and only occurs in 3% of persons affected with RP, and is sometimes seen in a relation with concomitant vasculitis.[3] The most common neurological manifestation are palsies of the cranial nerves V and VII. Also hemiplegia, ataxia, myelitis and polyneuropathy have been reported in scientific literature. Very rare neurological manifestations include aseptic meningitis, meningoencephalitis, stroke, focal or generalized seizures and intracranial aneurysm.[3][5] Magnetic Resonance Imaging of the brain shows multifocal areas of enhancement consistent with cerebral vasculitis in some cases.[4]
Kidney
The involvement of the kidney can be caused by primary renal parenchymal lesions, or an underlying vasculitis, or another associated autoimmune disease. Actual kidney involvement is quite rare, elevated creatinine levels are reported in approximately 10% of people with RP, and abnormalities in urinalysis in 26%. Involvement of the kidney often indicates a worse prognosis, with a 10-year survival rate of 30%.[3][4][5] The most common histopathologic finding is mild mesangial proliferation, that is followed by focal and segmental necrotizing glomerulonephritis with crescents. Other abnormalities that are found include glomerulosclerosis, IgA nephropathy and interstitial nephritis. Immunofluorescence studies most often reveal faint deposists of C3, IgG or IgM in the primarily mesangium.[4]
Constitutional symptoms
These symptoms could consist of asthenia, fever, anorexia, and weight loss. It mostly occurs during a severe disease flare.[3][4]
Others
- Skin and mucous membranes:20-30% of people with relapsing polychondritis have skin involvement, including aphthous ulcers, genital ulcers, and a number of non-specific skin rashes including erythema nodosum, livedo reticularis, hives, and erythema multiforme.[6]
- Cardiovascular system: Relapsing polychrondritis may cause inflammation of the aorta. It can also cause leaky heart valves (aortic valve regurgitation in 4-10%, mitral valve regurgitation in 2%).[6]
Causes
Relapsing polychondritis is an autoimmune disease[10] in which the body's immune system begins to attack and destroy the cartilage tissues in the body. It has been postulated that both cell-mediated immunity and humoral immunity are responsible.[6]
Reasons for disease onset are not known, but there is no evidence of a genetic predisposition to developing relapsing polychondritis.[6] However, there are cases where multiple members of the same family have been diagnosed with this illness. Studies indicate that some genetic contribution to susceptibility is likely.[medical citation needed]
Diagnosis
There is no specific test for relapsing polychondritis. Some people may exhibit abnormal lab results while others may have completely normal labs even during active flares.
Diagnostic criteria
There are several clinical criteria used to diagnose this disease. McAdam et al. introduced the clinical criteria for RP in 1976.[5][9] These clinical criteria have later been expanded by Damiani et al. in 1979 and finally Michet et al. modified them in 1986.[5][11][12] See the following table for these diagnostic clinical criteria and the number of conditions required for an official diagnosis.
| Authors | Criteria | Conditions required |
|---|---|---|
| McAdam et al. |
|
3 out of 6 criteria |
| Damiani et al. |
|
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| Michet et al. |
|
|
Laboratory findings
Patients presenting with acute episodes often have high levels of inflammatory markers such as erythrocyte sedimentation rate or C-reactive protein, ESR or CRP. Patients often have cartilage-specific antibodies present during acute relapsing polychondritis episodes. Antinuclear antibody reflexive panel, rheumatoid factor, and antiphospholipid antibodies are tests that may assist in the evaluation and diagnosis of autoimmune connective-tissue diseases.[citation needed]
Imaging studies
Imaging studies including MRI, CT scans, and X-rays may reveal inflammation and/or damaged cartilage facilitating diagnosis.[citation needed]
Special tests
Biopsy
Biopsy of the cartilage tissue (for example, ear) may show tissue inflammation and destruction, and may help with the diagnosis. The Biopsy of cartilage in patients with relapsing polychondritis may demonstrate chondrolysis, chondritis, and perichondritis.[citation needed]
Pulmonary function tests
It is useful to do a full set of pulmonary function tests, including inspiratory and expiratory flow-volume loops. Patterns consistent with either extrathoracic or intrathoracic obstruction (or both) may occur in this disease. Pulmonary function tests (flow-volume loops) provide a useful noninvasive means of quantifying and following the degree of extrathoracic airway obstruction in relapsing polychondritis.[13]
Associated diseases
There are several other overlapping diseases associated with RP, that should also be taken into account. About one third of people with RP might be associated with other autoimmune diseases, vasculitides and hematologic disorders.[5] Systemic vasculitis is the most common association with RP, followed by rheumatoid arthritis and systemic lupus erythematosus.[14] The following table displays the main diseases in association with RP.
| Class of disease | Specific type of disease |
|---|---|
| Vasculitides | Granulomatosis with polyangiitis,[5] Chürg-Strauss syndrome,[5] Polyarteritis nodosa,[5] Behçet's disease,[5][14] Takayasu's arteritis,[5] Leukocytoclastic vasculitis,[5] Temporal arteritis[5] and Systemic vasculitis.[14] |
| Autoimmune diseases | Systemic lupus erythematosus,[5][14] Systemic scleroderma,[5] Mixed connective tissue disease,[5][14] Autoimmune thyroiditis,[5] Sjögren's syndrome,[5] Dermatomyositis,[5] Antiphospholipid syndrome,[5] Autoimmune hemolytic anemia,[5] Hashimoto's thyroiditis.[14] |
| Other Rheumatologic diseases | Rheumatoid arthritis,[5][14] Spondyloarthropathy,[5][14] Reactive arthritis,[5] Polymyalgia rheumatica.[5][14] |
| Hematologic disorders | Myelodysplasia,[5] Myeloproliferative neoplasm.[5][14] |
| Dermatologic diseases | Psoriasis,[5] atopic dermatitis,[5] lichen ruber planus,[5] vitiligo.[5] |
| Autoinflammatory diseases | Familial Mediterranean fever.[5] |
| Others | Primary biliary cirrhosis,[5][14] ulcerative colitis,[5] Crohn's disease,[5] diabetes mellitus,[5] Pulmonary fibrosis.[14] |
Differential diagnosis
A differential diagnosis should be taken into account with the following main RP manifestations.[5]
| Manifestation of RP | Differential diagnosis |
|---|---|
| Arthritis | Rheumatoid arthritis |
| Auricular chondritis | Infectious perichondritis, injury, insect bites and stings, ear erysipelas, cystic chondromalacia, overexposure to extreme cold temperatures or to sunlight, frostbite of the ear, congenital syphilis. |
| Airway/kidney involvement | Granulomatosis with polyangiitis, bronchial asthma. |
| Nose cartilage involvement/saddle nose | Leishmaniasis, congenital syphilis, leprosy aspergillosis, paracoccidioidomycosis, Cocaine inhalation, systemic lupus erythematosus. |
| Subglottic stenosis | Prior endotracheal intubation, amyloidosis, sarcoidosis. |
| Vascular involvement | Takayasu's arteritis, polyarteritis nodosa, Behçet's disease, antiphospholipid syndrome. |
| Vestibular disease | Posterior circulation infarct, vestibulitis, benign paroxysmal vertigo, Ménière's disease. |
Treatment
There are no prospective randomized controlled trials studying therapies for relapsing polychondritis. Evidence for efficacy of treatments is based on case reports and series of small groups of patients.[citation needed]
For mild cases limited to joint pain or arthritis, oral nonsteroidal antiinflammatory drugs (NSAIDs) may be used. Other treatments typically involve medications to suppress the immune system. Corticosteroids are frequently used for more serious disease. Steroid-sparing medications such as azathioprine or methotrexate may be used to minimize steroid doses and limit the side effects of steroids. For severe disease cyclophosphamide is often given in addition to high dose intravenous steroids.[6]
Prognosis
Many individuals have mild symptoms, which recur infrequently, while others may have persistent problems that become debilitating or life-threatening.[15]
Epidemiology
Relapsing polychondritis occurs as often in men as in women. In a Mayo Clinic series, the annual incidence was about 3.5 cases per million. The highest incidence is between the ages of 40 and 50 years, but it may occur at any age.[6]
History
In 1923 Rudolf Jaksch von Wartenhorst first discovered Relapsing polychondritis while working in Prague and initially named it Polychondropathia.[16][17]
The discoverer of Relapsing polychondritis Rudolf Jaksch von Wartenhorst.
His patient was a 32-year-old male brewer who presented with fever, asymmetric polyarthritis, and the ears and nose showed signs of swelling, deformity and were painful. Biopsy of nasal cartilage revealed loss of the cartilage matrix and a hyperplastic mucous membrane. Jaksch von Wartenhorst considered this was an undescribed degenerative disorder of cartilage and named it Polychondropathia. He even took his patient's occupation into consideration, and related the cause to excessive alcohol intake.[17]
Since then, the disease has received many names. The following table shows the history of the nomenclature of Relapsing polychondritis. The current name, Relapsing Polychondritis (RP), was introduced by Pearson and his colleagues in 1960 to emphasize the episodic course of the disease.[17][18]
| Suggested name | Author(s) and year |
|---|---|
| Polychondropathia | Rudolf Jaksch von Wartenhorst in 1923 |
| Chondromalacia | Von Meyenburg in 1936 and Altherr in 1936 |
| Panchondritis | Harders in 1954 |
| Polychondritis chronica atrophicans | Bober and Czarniecki in 1955 |
| Chronic atrophic polychondritis | Bean, Drevets, and Chapman in 1958 |
| Relapsing polychondritis | Pearson, Kline, and Newcomer in 1960 |
| Atrophic polychondritis | Rhys Davies and Kelsall in 1961 |
Research
There has been little research on neurological problems related to RP.[3] If these cartilage structures get inflamed, they could press against nerves and cause a variety of problems that is seen in RP like peripheral neuropathy and many more.[3][5]
References
- ^ Starr, JC; Taneja, N; Brasher, GW (2010). "Relapsing polychondritis following alopecia areata.". Case reports in medicine 2010: 623158. doi:10.1155/2010/623158. PMID 20672055.
- ^ a b Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
- ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at Puéchal, X; Terrier, B; Mouthon, L; Costedoat-Chalumeau, N; Guillevin, L; Le Jeunne, C (March 2014). "Relapsing polychondritis.". Joint, bone, spine : revue du rhumatisme 81 (2): 118–24. doi:10.1016/j.jbspin.2014.01.001. PMID 24556284.
- ^ a b c d e f g h i j Drosos, Alexandros A. (October 2004). "Prof.". Orphanet encyclopedia.
- ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as Cantarini, L; Vitale, A; Brizi, MG; Caso, F; Frediani, B; Punzi, L; Galeazzi, M; Rigante, D (2014). "Diagnosis and classification of relapsing polychondritis.". Journal of autoimmunity. 48-49: 53–9. doi:10.1016/j.jaut.2014.01.026. PMID 24461536.
- ^ a b c d e f g Chopra R (May 2013). "Relapsing Polychondritis". Rheum Dis Clin N Am 39 (2): 263–276. doi:10.1016/j.rdc.2013.03.002. PMID 23597963.
- ^ Zeuner, M; Straub, RH; Rauh, G; Albert, ED; Schölmerich, J; Lang, B (January 1997). "Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients.". The Journal of rheumatology 24 (1): 96–101. PMID 9002018.
- ^ Mathew, SD; Battafarano, DF; Morris, MJ (August 2012). "Relapsing polychondritis in the Department of Defense population and review of the literature.". Seminars in arthritis and rheumatism 42 (1): 70–83. doi:10.1016/j.semarthrit.2011.12.007. PMID 22417894.
- ^ a b McAdam, LP; O'Hanlan, MA; Bluestone, R; Pearson, CM (May 1976). "Relapsing polychondritis: prospective study of 23 patients and a review of the literature.". Medicine 55 (3): 193–215. doi:10.1097/00005792-197605000-00001. PMID 775252.
- ^ "Relapsing Polychondritis: Autoimmune Disorders of Connective Tissue". Merck Manual Home Health Handbook.
- ^ Damiani, JM; Levine, HL (June 1979). "Relapsing polychondritis--report of ten cases.". The Laryngoscope 89 (6 Pt 1): 929–46. doi:10.1288/00005537-197906000-00009. PMID 449538.
- ^ Michet CJ, Jr; McKenna, CH; Luthra, HS; O'Fallon, WM (January 1986). "Relapsing polychondritis. Survival and predictive role of early disease manifestations.". Annals of internal medicine 104 (1): 74–8. doi:10.7326/0003-4819-104-1-74. PMID 3484422.
- ^ Stone, J.H. (2013). CURRENT Rheumatology Diagnosis & Treatment (3e ed.). New York, NY: McGraw-Hill. pp. Chapter 28, relapsing polychondritis.
|access-date=requires|url=(help) - ^ a b c d e f g h i j k l Langford, Carol A. (2015). Harrison's Principles of Internal Medicine (19th ed.). New York, NY: McGraw-Hill. p. 389: Relapsing Polychondritis. ISBN 978-0-07-1802161.
- ^ http://www.polychondritis.org/what-is-rp/
- ^ Jaksch Von Wartenhorst, Rudolf (1923). "Polychondropathia". Wiener Archiv Für Innere Medizin (Urban & Schwarzenberg) (6): 93–100.
- ^ a b c Ratnesh Chopra, MD, Nida Chaudhary, MD, Jonathan Kay, MD* (2013). "Relapsing Polychondritis". Rheum Dis Clin N Am 39 (2): 263–276. doi:10.1016/j.rdc.2013.03.002. PMID 23597963.
- ^ H. RHYS DAVIES AND A. R. KELSALL (1961). "ATROPHIC POLYCHONDRITIS WITH THE REPORT OF A CASE". Ann. rheum. Dis. 20 (186). Retrieved 2 March 2015.
External links
- Trentham DE, Le CH (July 1998). "Relapsing polychondritis". Ann. Intern. Med. 129 (2): 114–22. doi:10.7326/0003-4819-129-2-199807150-00011. PMID 9669970.
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UpToDate Contents
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- 1. 再発性多発性軟骨炎の臨床症状 clinical manifestations of relapsing polychondritis
- 2. 再発性多発性軟骨炎の治療 treatment of relapsing polychondritis
- 3. 再発性多発性軟骨炎の診断的評価 diagnostic evaluation of relapsing polychondritis
- 4. 再発性多発性軟骨炎の病理 pathology of relapsing polychondritis
- 5. 再発性多発性軟骨炎の病因および発症機序 etiology and pathogenesis of relapsing polychondritis
English Journal
- [Disorders of the Larynx and Chronic Inflammatory Diseases.]
- Pickhard A, Smith E, Rottscholl R, Brosch S, Reiter R.SourceHNO, Technische Universität München, München.
- Laryngo- rhino- otologie.Laryngorhinootologie.2012 Oct 8. [Epub ahead of print]
- Chronic inflammatory diseases including tuberculosis, rheumatic disorders (rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, Wegeners's granulomatosis, relapsing polychondritis) and reflux disease are considered as systemic diseases, and may affect the larynx. The clinical symptoms ar
- PMID 23044789
- [18F]fluorodeoxyglucose positron emission tomography imaging in a case of relapsing polychondritis.
- Cassone G, Lo Gullo A, Bajocchi G, Salvarani C.SourceUnità Operativa di Reumatologia, Arcispedale S. Maria Nuova, Viale Risorgimento 80, Reggio Emilia 42121, Italy. Baiocchi.Gianluigi@asmn.re.it.
- Rheumatology (Oxford, England).Rheumatology (Oxford).2012 Oct;51(10):1813. Epub 2012 Jul 23.
- PMID 22829695
Japanese Journal
- 気管に限局した再発性多発軟骨炎の1例
- 日本耳鼻咽喉科学会会報 118(9), 1150-1154, 2015
- NAID 130005103261
- Relapsing Polychondritis Followed Up with FDG-PET
- Internal Medicine 54(13), 1675-1676, 2015
- NAID 130005086456
- 抗グルタミン酸受容体（GluRε2）抗体が検出された非ヘルペス性急性辺縁系脳炎を合併した両側耳介軟骨炎の1例
- 臨床神経学 55(6), 395-400, 2015
- NAID 130005083886
Related Links
- Read about relapsing polychondritis, a chronic disorder characterized by recurrent episodes of inflammation of the cartilage of various tissues of the body. ... Relapsing polychondritis is an uncommon, chronic disorder of ...
- My story: November 11, 1999-- If you've found this page you probably already know what relapsing polychondritis (RP) is. (If you don't know, you can read an article by Dr. Trentham, one of the foremost ...
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★リンクテーブル★
| リンク元 | 「再発性多発軟骨炎」「再発性多発性軟骨炎」「反復性多発性軟骨炎」 |
| 関連記事 | 「relapsing」 |
「再発性多発軟骨炎」
参考
uptodate
- 1. [charged] 再発性多発性軟骨炎の病因および発症機序 - uptodate [1]
- 2. [charged] 再発性多発性軟骨炎の病理 - uptodate [2]
- 3. [charged] 再発性多発性軟骨炎の臨床症状 - uptodate [3]
- 4. [charged] 再発性多発性軟骨炎の診断的評価 - uptodate [4]
- 5. [charged] 再発性多発性軟骨炎の治療 - uptodate [5]
「再発性多発性軟骨炎」
「反復性多発性軟骨炎」
「relapsing」
- adj.
- 再発性の