reignite

　

WordNet

1. ignite anew, as of something burning; "The strong winds reignited the cooling embers"

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• 1. 局所化学熱傷 topical chemical burns

English Journal

• Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane.

• Kenwood BM1, Weaver JL1, Bajwa A2, Poon IK3, Byrne FL1, Murrow BA1, Calderone JA4, Huang L2, Divakaruni AS5, Tomsig JL1, Okabe K6, Lo RH7, Cameron Coleman G1, Columbus L7, Yan Z8, Saucerman JJ9, Smith JS10, Holmes JW9, Lynch KR1, Ravichandran KS3, Uchiyama S6, Santos WL4, Rogers GW11, Okusa MD2, Bayliss DA1, Hoehn KL12.Author information 1Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.2Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.3Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.4Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, USA.5Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.6University of Tokyo, Tokyo, Japan.7Department of Chemistry, University of Virginia, Charlottesville, VA 22908, USA.8Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA ; Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA ; Department of Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA.9Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA ; Department of Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA.10Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.11Seahorse Bioscience, North Billerica, MA 01862, USA.12Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA ; Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA ; Department of Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA ; Emily Couric Clinical Cancer Center, University of Virginia, Charlottesville, VA 22908, USA.AbstractDysregulation of oxidative phosphorylation is associated with increased mitochondrial reactive oxygen species production and some of the most prevalent human diseases including obesity, cancer, diabetes, neurodegeneration, and heart disease. Chemical 'mitochondrial uncouplers' are lipophilic weak acids that transport protons into the mitochondrial matrix via a pathway that is independent of ATP synthase, thereby uncoupling nutrient oxidation from ATP production. Mitochondrial uncouplers also lessen the proton motive force across the mitochondrial inner membrane and thereby increase the rate of mitochondrial respiration while decreasing production of reactive oxygen species. Thus, mitochondrial uncouplers are valuable chemical tools that enable the measurement of maximal mitochondrial respiration and they have been used therapeutically to decrease mitochondrial reactive oxygen species production. However, the most widely used protonophore uncouplers such as carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP) and 2,4-dinitrophenol have off-target activity at other membranes that lead to a range of undesired effects including plasma membrane depolarization, mitochondrial inhibition, and cytotoxicity. These unwanted properties interfere with the measurement of mitochondrial function and result in a narrow therapeutic index that limits their usefulness in the clinic. To identify new mitochondrial uncouplers that lack off-target activity at the plasma membrane we screened a small molecule chemical library. Herein we report the identification and validation of a novel mitochondrial protonophore uncoupler (2-fluorophenyl){6-[(2-fluorophenyl)amino](1,2,5-oxadiazolo[3,4-e]pyrazin-5-yl)}amine, named BAM15, that does not depolarize the plasma membrane. Compared to FCCP, an uncoupler of equal potency, BAM15 treatment of cultured cells stimulates a higher maximum rate of mitochondrial respiration and is less cytotoxic. Furthermore, BAM15 is bioactive in vivo and dose-dependently protects mice from acute renal ischemic-reperfusion injury. From a technical standpoint, BAM15 represents an effective new tool that allows the study of mitochondrial function in the absence of off-target effects that can confound data interpretation. From a therapeutic perspective, BAM15-mediated protection from ischemia-reperfusion injury and its reduced toxicity will hopefully reignite interest in pharmacological uncoupling for the treatment of the myriad of diseases that are associated with altered mitochondrial function.
• Molecular metabolism.Mol Metab.2013 Nov 28;3(2):114-23. doi: 10.1016/j.molmet.2013.11.005. eCollection 2014.
• Dysregulation of oxidative phosphorylation is associated with increased mitochondrial reactive oxygen species production and some of the most prevalent human diseases including obesity, cancer, diabetes, neurodegeneration, and heart disease. Chemical 'mitochondrial uncouplers' are lipophilic weak ac
• PMID 24634817

• The truth and coherence behind the concept of overdrainage of cerebrospinal fluid in hydrocephalic patients.

• Cheok S1, Chen J, Lazareff J.Author information 1Department of Neurosurgery, UCLA David Geffen School of Medicine, 10833 Le Conte Avenue, 13-154 CHS, Los Angeles, CA, 90095, USA.AbstractINTRODUCTION: Overdrainage, siphoning, and slit-ventricle syndrome are well-documented complications of shunting in hydrocephalic patients. Despite the prevalence of these conditions, their mechanisms are still not fully understood. In this paper, the authors trace the concept of overdrainage and the related phenomena of siphoning and slit-ventricle syndrome.
• Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery.Childs Nerv Syst.2014 Jan 15. [Epub ahead of print]
• INTRODUCTION: Overdrainage, siphoning, and slit-ventricle syndrome are well-documented complications of shunting in hydrocephalic patients. Despite the prevalence of these conditions, their mechanisms are still not fully understood. In this paper, the authors trace the concept of overdrainage and th
• PMID 24425583

• Histone Crosstalk: H2Bub and H3K4 Methylation.

• Soares LM1, Buratowski S.Author information 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.AbstractTwo new studies in this issue of Molecular Cell (Kim et al., 2013 and Wu et al., 2013) provide new insights and reignite debate over how histone H2B ubiquitination promotes methylation of histone H3 lysine 4.
• Molecular cell.Mol Cell.2013 Mar 28;49(6):1019-20. doi: 10.1016/j.molcel.2013.03.012.
• Two new studies in this issue of Molecular Cell (Kim et al., 2013 and Wu et al., 2013) provide new insights and reignite debate over how histone H2B ubiquitination promotes methylation of histone H3 lysine 4.Copyright © 2013 Elsevier Inc. All rights reserved.
• PMID 23541037

Japanese Journal

• 入学時に大学に対する不本意感および学業へのつまずき感を有する学生の特徴;Characteristics of the university freshmen who are unwilling to join theuniversity and who feel anxiety about academic learning

• 工学教育研究;KIT progress (24), 53-62, 2016
• NAID 120005847481

• グローバリゼーション下における連鎖的なバブルの形成と崩壊(グローバリゼーション下の経済金融危機と国家-新たな金融・財政政策の展開を踏まえて,第59回大会共通論題)

• 季刊経済理論 49(1), 14-23, 2012-04-20
• NAID 110009820329

• フォーリン・アフェアーズ・アップデート カダフィ後のリビア--選挙を急げば再び内戦になる (特集 After the Arab Spring)

• フォーリン・アフェアーズ・リポート 2011(10), 77-80, 2011-10
• NAID 40019027536

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