English Journal

Modification of the length and structure of the linker of N(6)-benzyladenosine modulates its selective antiviral activity against enterovirus 71.

Drenichev MS1, Oslovsky VE1, Sun L2, Tijsma A2, Kurochkin NN1, Tararov VI1, Chizhov AO3, Neyts J2, Pannecouque C2, Leyssen P2, Mikhailov SN4.
European journal of medicinal chemistry.Eur J Med Chem.2016 Mar 23;111:84-94. doi: 10.1016/j.ejmech.2016.01.036. Epub 2016 Jan 26.
Very recently, we demonstrated that N(6)-isopentenyladenosine, a cytokinin nucleoside, exerts a potent and selective antiviral effect on the replication of human enterovirus 71. The present study is devoted to the structure optimization of another natural compound: N(6)-benzyladenosine. We mainly fo
PMID 26854380

Pyrone Diels-Alder Routes to Indolines and Hydroindolines: Syntheses of Gracilamine, Mesembrine, and Δ(7) -Mesembrenone.

Gan P1, Smith MW2,1, Braffman NR2, Snyder SA3,4,5.
Angewandte Chemie (International ed. in English).Angew Chem Int Ed Engl.2016 Mar 7;55(11):3625-30. doi: 10.1002/anie.201510520. Epub 2016 Feb 10.
Although the Diels-Alder reaction has long been utilized for the preparation of numerous heterocycles, opportunities to extend its power remain. Herein, we detail a simple, modular, and robust approach that combines various amines regioselectively with 4,6-dichloropyrone to create substrates which,
PMID 26865400

Switching the cleavage sites in palladium on carbon-catalyzed carbon-carbon bond disconnection.

Hattori T, Takakura R, Ichikawa T, Sawama Y, Monguchi Y, Sajiki H.
The Journal of organic chemistry.J Org Chem.2016 Mar 4. [Epub ahead of print]
We have demonstrated a palladium on carbon catalyzed approach to regioselectively alter the cleavage sites of the C-C bonds of cinnamaldehyde derivatives by the slight change of the reaction conditions in isopropanol under O2 atmosphere. Styrene derivatives could be selectively formed by the additio
PMID 26944077

Japanese Journal

Alteration of the substrate specificity of cytochrome P450 CYP199A2 by site-directed mutagenesis(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)

Furuya Toshiki,Shitashima Yoh,Kino Kuniki
Journal of bioscience and bioengineering 119(1), 47-51, 2015-01
… In whole-cell assays with p-methylbenzylalcohol and phenol as hydroxy aromatic substrates, the S247D mutant regioselectively oxidized these compounds to 1,4-benzenedimethanol and hydroquinone, respectively, although the wild-type enzyme exhibited no oxidation activity for these compounds. …
NAID 110009892232

DBU-promoted regioselective HBr-elimination of vicinal dibromides: effects of the adjacent oxygen and/or other heterofunctional groups

Kutsumura Noriki,Toguchi Shohei,Iijima Masatoshi,Tanaka Osamu,Iwakura Izumi,Saito Takao
Tetrahedron 70(43), 8004-8009, 2014-10
… These HBr-eliminations proceeded more or less regioselectively, and all associated calculation results agreed with the experimental facts. …
NAID 120005516380

Regioselective Preparation of 4-Nitro-o-xylene Using Nitrogen Dioxide/Molecular Oxygen over Zeolite Catalysts. Remarkable Enhancement of para-Selectivity

, , , ,
Chemistry Letters 43(6), 817-819, 2014
… In the presence of molecular oxygen and zeolite H-β with Si/Al2 = 500, o-xylene reacted regioselectively with liquid nitrogen dioxide at 35 °C to yield mononitro-o-xylenes as the main product, where the 4-nitro-o-xylene isomer predominated up to 89% and the 4-nitro-/3-nitro-o-xylene isomer ratio improved to 7.8. …
NAID 130004868143

リンク元	「位置選択的」
関連記事	「regioselective」