WordNet
- (of genes) producing its characteristic phenotype only when its allele is identical
- a gene that disposes normal cells to change into cancerous tumor cells (同)transforming_gene
PrepTutorEJDIC
- 後退する,退行の / (遺伝が)劣性の / 劣性遺伝形質
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English Journal
- RhoBTB2 gene in breast cancer is silenced by promoter methylation.
- Tang W1, Wang C1, Fu F2, Chen Q1.Author information 1Department of Oncology, Graduate School of Education, Fujian Medical University, Fuzhou, Fujian, P.R. China.2Department of Galactophore Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, Fujian, P.R. China.AbstractMutation analysis in breast cancer has failed to explain the inactivation of RhoBTB2, a candidate breast cancer tumor suppressor gene on chromosome 8p. Some breast cancer‑related genes in this region become inactivated by hypermethylation, and hypermethylation of RhoBTB2 abrogates its expression in bladder cancers. The aim of the present study was to determine whether RhoBTB2 was silenced by methylation in breast cancer. Nested methylation‑specific PCR (nMSP) and quantitative reverse transcription PCR were used to analyze the methylation status and mRNA levels of RhoBTB2 in 50 paired breast cancer and normal tissues and the results were correlated with clinicopathological characteristics. Promoter methylation and the downregulation of RhoBTB2 mRNA was observed in tumor tissues (P<0.001). mRNA levels were decreased in samples with methylation (χ2 = 15.751, P<0.001). RhoBTB2 methylation was observed preferentially in progesterone receptor (PR)‑negative samples (P<0.05). The results demonstrated that aberrant methylation of RhoBTB2 may be responsible for the suppression of RhoBTB2 mRNA expression in breast cancer, a significant event during the genesis of breast cancer that correlated with PR status.
- International journal of molecular medicine.Int J Mol Med.2014 Mar;33(3):722-8. doi: 10.3892/ijmm.2013.1593. Epub 2013 Dec 18.
- Mutation analysis in breast cancer has failed to explain the inactivation of RhoBTB2, a candidate breast cancer tumor suppressor gene on chromosome 8p. Some breast cancer‑related genes in this region become inactivated by hypermethylation, and hypermethylation of RhoBTB2 abrogates its expression i
- PMID 24356943
- Array CGH analysis of a cohort of Russian patients with intellectual disability.
- Kashevarova AA1, Nazarenko LP2, Skryabin NA2, Salyukova OA2, Chechetkina NN2, Tolmacheva EN2, Sazhenova EA2, Magini P3, Graziano C3, Romeo G3, Kučinskas V4, Lebedev IN2.Author information 1Institute of Medical Genetics, Tomsk, Russia. Electronic address: anna.kashevarova@medgenetics.ru.2Institute of Medical Genetics, Tomsk, Russia.3University of Bologna, Bologna, Italy.4Vilnius University, Department of Human and Medical Genetics, Vilnius, Lithuania.AbstractThe use of array comparative genomic hybridization (array CGH) as a diagnostic tool in molecular genetics has facilitated the identification of many new microdeletion/microduplication syndromes (MMSs). Furthermore, this method has allowed for the identification of copy number variations (CNVs) whose pathogenic role has yet to be uncovered. Here, we report on our application of array CGH for the identification of pathogenic CNVs in 79 Russian children with intellectual disability (ID). Twenty-six pathogenic or likely pathogenic changes in copy number were detected in 22 patients (28%): 8 CNVs corresponded to known MMSs, and 17 were not associated with previously described syndromes. In this report, we describe our findings and comment on genes potentially associated with ID that are located within the CNV regions.
- Gene.Gene.2014 Feb 15;536(1):145-50. doi: 10.1016/j.gene.2013.11.029. Epub 2013 Nov 27.
- The use of array comparative genomic hybridization (array CGH) as a diagnostic tool in molecular genetics has facilitated the identification of many new microdeletion/microduplication syndromes (MMSs). Furthermore, this method has allowed for the identification of copy number variations (CNVs) whose
- PMID 24291026
Japanese Journal
- ヒト骨・軟部腫瘍における優性および劣性癌遺伝子の変異に関する研究
- 尾崎 敏文
- 岡山医学会雑誌 101(5-6), 589-602, 1989-06
- … To examine alterations in the dominant oncogenes in the osteosarcoma and other bone and soft tissue tumors, DNA extracted from 12 bone tumors, 12 soft part tumors and 2 cells lines was hybridized with c-oncogene (c-myc, c-sis, c-raf-1, c-fos, K-ras2, c-erbB, c-fms, c-fos). … DNA extracted from the same samples was examined with Rb cDNA (p0.9R, p3.8R) probes, the retinoblastoma gene (Rb gene) localized at 13q14, to analize whether a recessive mutation is a target in osteosarcoma, and other bone and soft tissue tumors. …
- NAID 120002674313
Related Links
- Page 1 1179 Recessive Oncogenes Robert Bookstein, M.D., and D. Craig Allred, M.D. Tumor-suppressor genes (antioncogenes or recessive oncogenes) are cancer genes that achieve their oncogenic effect by mutational inactivation ...
- How to Cite Bookstein, R. and Allred, D. C. (1993), Recessive oncogenes. Cancer, 71: 1179–1186. doi: 10.1002/1097-0142(19930201)71:3+<1179::AID-CNCR2820711442 ... Author Information Institute of Biotechnology and the ...
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- 関
- inferior、recessively、recessiveness