受容体エンドサイトーシス
WordNet
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- =sense organ / 受信装置
UpToDate Contents
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English Journal
- Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles.
- Xin H, Sha X, Jiang X, Zhang W, Chen L, Fang X.SourceKey Laboratory of Smart Drug Delivery, Ministry of Education & PLA, School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, China; Department of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing 210029, China.
- Biomaterials.Biomaterials.2012 Nov;33(32):8167-76. Epub 2012 Aug 11.
- Therapeutic effect of glioma is often limited due to low permeability of delivery systems across the Blood-Brain Barrier (BBB) and poor penetration into the tumor tissue. In order to overcome the two barriers, we proposed Angiopep-conjugated PEG-PCL nanoparticles (ANG-PEG-NP) as a dual targeting dru
- PMID 22889488
- Recycling of EGFR and ErbB2 is associated with impaired Hrs tyrosine phosphorylation and decreased deubiquitination by AMSH.
- Meijer IM, van Rotterdam W, van Zoelen EJ, van Leeuwen JE.AbstractErbB receptors play an important role in normal cellular growth, differentiation and development, but overexpression or poor downregulation can result in enhanced signaling and cancerous growth. ErbB signaling is terminated by clathrin-dependent receptor-mediated endocytosis, followed by incorporation in multi-vesicular bodies and subsequent degradation in lysosomes. In contrast to EGFR, ErbB2 displays poor ligand-induced downregulation and enhanced recycling, but the molecular mechanisms underlying this difference are poorly understood. Given our previous observation that both EGFR and an EGFR-ErbB2 chimera undergo Cbl-mediated K63-polyubiquitination, we investigated in the present study whether activation of the EGFR and the EGFR-ErbB2 chimera is associated with tyrosine phosphorylation of the ESCRT-0 complex subunit Hrs and AMSH-mediated deubiquitination. EGF stimulation of the EGFR resulted in efficient Hrs tyrosine phosphorylation and deubiquitination by the K63-polyubiquitin chain-specific deubiquitinating enzyme AMSH. In contrast, EGF activation of EGFR-ErbB2 showed significantly decreased Hrs tyrosine phosphorylation and deubiquitination by AMSH. To test whether this phenotype is the result of endosomal recycling, we induced recycling of the EGFR by stimulation with TGFα. Indeed, even though TGFα-stimulation of EGFR is associated with efficient ligand-stimulated K63-polyubiquitination, we observed that Hrs tyrosine phosphorylation as well as AMSH-mediated deubiquitination is significantly reduced under these conditions. Using various EGFR-ErbB2 chimeras, we demonstrate that enhanced recycling, decreased Hrs tyrosine phosphorylation and decreased AMSH mediated deubiquitination of EGFR-ErbB2 chimeras is primarily due to the presence of ErbB2 sequences or the absence of EGFR sequences C-terminal to the Cbl binding site. We conclude that endosomal recycling of the EGFR and ErbB2 receptors is associated with significantly impaired tyrosine phosphorylation of the ESCRT-0 subunit Hrs as well as decreased deubiquitination by AMSH, which is consistent with the finding that recycling receptors are not efficiently incorporated in the MVB pathway.
- Cellular signalling.Cell Signal.2012 Nov;24(11):1981-8. Epub 2012 Jul 16.
- ErbB receptors play an important role in normal cellular growth, differentiation and development, but overexpression or poor downregulation can result in enhanced signaling and cancerous growth. ErbB signaling is terminated by clathrin-dependent receptor-mediated endocytosis, followed by incorporati
- PMID 22800866
Japanese Journal
- Liposomal Lipopolysaccharide Initiates TRIF-Dependent Signaling Pathway Independent of CD14.
- Watanabe Sachiko,Kumazawa Yoshio,Inoue Joe
- PloS one 8(4), 2013-04-02
- … Lipopolysaccharide (LPS) is recognized by CD14 with Toll-like receptor 4 (TLR4), and initiates 2 major pathways of TLR4 signaling, the MyD88-dependent and TRIF-dependent signaling pathways. … CD14 plays a critical role in initiating the TRIF-dependent signaling pathway response to LPS, to support the internalization of LPS via endocytosis. …
- NAID 120005244422
- A-6 ナノ銀粒子が細胞に与える影響 : 2次元および3次元培養の比較(生体反応・臨床応用,一般講演(口頭発表),第61回日本歯科理工学会学術講演会)
- 橋本 正則,戸島 洋和,米澤 徹,河合 功治,加我 正行,遠藤 一彦
- 日本歯科理工学会誌 32(2), 86, 2013-03-25
- … The NPs were taken up by receptor-mediated endocytosis, in which particles aggregated in the vesicles. …
- NAID 110009596385
- Pharmacokinetic modeling of hepatocyte growth factor in experimental animals and humans
- Sugiura Tomoko,Takahashi Saki,Sano Kazusa,Abe Tetsushi,Fukuta Kazuhiro,Adachi Kiichi,Nakamura Toshikazu,Matsumoto Kunio,Nakamichi Noritaka,Kato Yukio
- Journal of Pharmaceutical Sciences 102(1), 237-249, 2013-01-00
- … Nevertheless, accumulation of fluorescein-4-isocyanate-labeled HGF in renal tubules in both cases suggests the occurrence of efficient endocytosis of HGF in kidney. … A pharmacokinetic model including plasma and liver compartments was constructed, incorporating both high- and low-affinity receptors for association and subsequent endocytosis of HGF because HGF is eliminated via specific receptor c-Met and heparin-like substance. …
- NAID 120005223453
Related Links
- Receptor mediated endocytosis is an endocytotic mechanism in which specific molecules are ingested into the cell. The specificity results from a receptor-ligand interaction. Receptors on the plasma membrane of the target tissue will ...
- Receptor-Mediated Endocytosis In contrast to phagocytosis, which plays only specialized roles, pinocytosis is common among eukaryotic cells. The best-characterized form of this process is receptor-mediated endocytosis, which ...
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エンドサイトーシス