Brain uptake of a non-radioactive pseudo-carrier and its effect on the biodistribution of [(18)F]AV-133 in mouse brain.
Wu X1, Zhou X1, Zhang S1, Zhang Y1, Deng A1, Han J1, Zhu L2, Kung HF3, Qiao J4.
Nuclear medicine and biology.Nucl Med Biol.2015 Jul;42(7):630-6. doi: 10.1016/j.nucmedbio.2015.03.009. Epub 2015 Apr 6.
INTRODUCTION: 9-[(18)F]Fluoropropyl-(+)-dihydrotetrabenazine ([(18)F]AV-133) is a new PET imaging agent targeting vesicular monoamine transporter type II (VMAT2). To shorten the preparation of [(18)F]AV-133 and to make it more widely available, a simple and rapid purification method using solid-phas
Carbon-11 radiolabelling of organosulfur compounds: (11) C synthesis of the progesterone receptor agonist tanaproget.
Haywood T1, Kealey S1, Sánchez-Cabezas S1, Hall JJ1, Allott L2, Smith G2, Plisson C3, Miller PW4.
Chemistry (Weinheim an der Bergstrasse, Germany).Chemistry.2015 Jun 15;21(25):9034-8. doi: 10.1002/chem.201501089. Epub 2015 May 12.
Herein a new (11) C radiolabelling strategy for the fast and efficient synthesis of thioureas and related derivatives using the novel synthon, (11) CS2 , is reported. This approach has enabled the facile labelling of a potent progesterone receptor (PR) agonist, [(11) C]Tanaproget, by the intramolecu
ChemMedChem.ChemMedChem.2015 Jun 1. doi: 10.1002/cmdc.201500198. [Epub ahead of print]
In the past few years, gallium-68 has demonstrated significant potential as a radioisotope for positron emission tomography (PET), and the optimization of chelators for gallium coordination is a major goal in the development of radiopharmaceuticals. Methylaminotriazacyclononane trimethylphosphinate
Synthesis of ^<11>C-Labelled Bis (phenylalkyl) amines and Their in Vitro and in Vivo Binding Properties in Rodent and Monkey Brains (Medicinal Chemistry)
… Two new ^<11>C-labelled ligands, N-(3-(4-hydroxyphenyl)propyl)-3-(4-methoxyphenyl)propylamine ([^<11>C]2) and N-(3-(4-hydroxyphenyl)butyl)-3-(4-methoxyphenyl)butylamine ([^<11>C]3) were designed based on bis (phenylalkyl)-amines (1) which have been reported as polyamine site antagonists with high-selectivity for NR1A/2B NMDA receptors, and radiolabelling of the corresponding phenol precursors with [^<11>C] methyl iodide was readily accomplished. …
Differentiating the Biosynthesis of Pseudomonic Acids A and B
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Journal of antibiotics 54(2), 166-174, 2001-02-25
… Since [methyl-14C] methionine only labels carbons in the 12-carbon part of the pseudomonate molecule that is thought to be an early biosynthetic moiety, the evidence from radiolabelling experiments implies that preferential early oxidation of this biosynthetic intermediate causes the pathway diversion to accumulate 2 instead of 1. …
Selcia's reputation for excellence in radiochemistry makes it the company of choice for the custom synthesis of carbon-14 radiolabelled compounds ... As the world’s largest independent supplier of custom carbon-14 radiochemicals ...
Go Back Radiolabelling with 99m Tc & Calculation of Doses Radiolabelling is the stage at which the radiopharmaceutical is prepared by mixing the radioactive eluate (99mTc in the chemical form of pertechnetate in a 0.9% NaCl ...