quinoxalinedione

English Journal

Synthesis and inhibitory effects of novel pyrimido-pyrrolo-quinoxalinedione analogues targeting nucleoproteins of influenza A virus H1N1.

Lin MI1, Su BH2, Lee CH3, Wang ST3, Wu WC3, Dangate P3, Wang SY1, Huang WI1, Cheng TJ1, Lin OA4, Cheng YS1, Tseng YJ5, Sun CM6.
European journal of medicinal chemistry.Eur J Med Chem.2015 Sep 18;102:477-86. doi: 10.1016/j.ejmech.2015.08.016. Epub 2015 Aug 13.
The influenza nucleoprotein (NP) is a single-strand RNA-binding protein and the core of the influenza ribonucleoprotein (RNP) particle that serves many critical functions for influenza replication. NP has been considered as a promising anti-influenza target. A new class of anti-influenza compounds,
PMID 26310893

Synthesis and first evaluation of [¹⁸F]fluorocyano- and [¹⁸F]fluoronitro-quinoxalinedione as putative AMPA receptor antagonists.

Olma S, Ermert J, Sihver W, Coenen HH1.
Medicinal chemistry (Shāriqah (United Arab Emirates)).Med Chem.2014;11(1):13-20.
Derivatives of quinoxalinedione (QX) were chosen as chemical lead for the development of new radioligands of the AMPA receptor, since there are several examples of QX-derivatives with high affinity. The radiosyntheses of the new compounds 6-[(18)F]fluoro-7-nitro-QX([(18)F]FNQX) and 7-[(18)F]fluoro-6
PMID 24773348

The formation of overlooked compounds in the reaction of methyl amine with the diethyl ester of o-phenylenebis(oxamic acid) in MeOH.

Abdulmalic MA1, Aliabadi A, Petr A, Kataev V, Rüffer T.
Dalton transactions (Cambridge, England : 2003).Dalton Trans.2013 Feb 7;42(5):1798-809. doi: 10.1039/c2dt32259e. Epub 2012 Nov 20.
The treatment of the diethyl ester of o-phenylenebis(oxamic acid) (opbaH(2)Et(2)) with 2/3 of an equivalent of MeNH(2) in MeOH does not result in the formation of the methyl ester of o-phenylene(N'-methyloxamide)(oxamic acid) (opooH(3)Me, 1) in pure state, as reported previously. The colourless crud
PMID 23165342

Application of LC-NMR for Characterization of Rat Urinary Metabolites of Zonampanel Monohydrate (YM872)

Sohda Kin-ya,Minematsu Tsuyoshi,Hashimoto Tadashi [他],SUZUMURA Ken-ichi,FUNATSU Masashi,SUZUKI Katsuhiro,IMAI Harumitsu,USUI Takashi,KAMIMURA Hidetaka
Chemical & pharmaceutical bulletin 52(11), 1322-1325, 2004-11-01
… The results showed that R1 and R2 have a hydroxyamino group and an amino group at the C-7 position of the quinoxalinedione skeleton, respectively. …
NAID 110003665440

Synthesis of 2,3,8-Trisubstituted 7H-Isoindolo[5,6-g]quinoxaline-5,7,9,11(8H)-tetraones

Effects of the Novel Tricyclic Quinoxalinedione Derivatives, SM-18400 and Its Analogs, on N-Methyl-D-aspartate (NMDA) Receptor-Mediated Synaptic Transmission in the Isolated Neonatal Rat Spinal Cord In Vitro

Maruoka Yoshimi,Ohno Yukihiro,Tanaka Hiroyasu [他],YASUDA Hirokazu,OTANI Ken-ichi,TAMAMURA Chika,NAKAMURA Mitsutaka
The Japanese journal of pharmacology 76(3), 265-270, 1998-03
… We examined the effects of novel tricyclic quinoxalinedione derivatives, SM-18400 ((S)-9-chloro-5-[p-aminomethyl-o-(carboxymethoxy)phenylcarbamoylmethyl]-6, 7-dihydro-1H, 5H-pyrido[1, 2, 3-de]quinoxaline-2, 3-dione hydrochloride trihydrate) and its analogs (i.e., ID-17263 and ID-17332), on the N-methyl-D-aspartate (NMDA) receptor-mediated polysynaptic reflex (PSR) in the isolated spinal cord of neonatal rats in vitro. …
NAID 10008191944