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a bitter alkaloid extracted from chinchona bark; used in malaria therapy

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キニーネ;キニーネ剤(マラリアの特効薬)

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1. 夜間の足痙攣nocturnal leg cramps [show details]
… that patients should be encouraged to read the given to them at the pharmacy before starting quinine sulfate and each time they get a refill . Patients should be cautioned to promptly report potentially …
2. 抗マラリア剤：概要antimalarial drugs an overview [show details]
…intravenous infusion, as both quinine and quinidine stimulate insulin production . Reduced quinine efficacy has been described in Southeast Asia . The mechanism for quinine resistance is complex and poorly …
3. 血栓性微小血管障害症drug induced thrombotic microangiopathy [show details]
… Eighteen (95 percent) were caused by a quinine tablet; one was caused by quinine in tonic water of a vodka/tonic drink . Eighteen (95 percent) had evidence of quinine-dependent antiplatelet (or antineutrophil) …
4. 重症マラリアの治療treatment of severe malaria [show details]
…faster than quinine and are associated with lower mortality rates in both adults and children . Artemisinins are active against a broader life cycle range of blood stage parasites than quinine and they are …
5. 成人の肝硬変：合併症、全般的なマネージメント、予後の概要cirrhosis in adults overview of complications general management and prognosis [show details]
…effect that occurred more often with quinine than with placebo. Quinine sulfate may act by reducing the excitability of the motor nerve . Note that quinine sulfate is not the same as quinidine sulfate …

English Journal

Screening study of SFC critical method parameters for the determination of pharmaceutical compounds.

Dispas A1, Lebrun P2, Sacré PY3, Hubert P3.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2016 Jun 5;125:339-54. doi: 10.1016/j.jpba.2016.04.005. Epub 2016 Apr 8.
Nowadays, supercritical fluid chromatography is commonly presented as a promising alternative technique in the field of separation sciences. Nevertheless the selection of chromatographic conditions and sample preparation of pharmaceutical compounds remain a challenge and peak distortion was previous
PMID 27105334

Monosodium glutamate derived tricolor fluorescent carbon nanoparticles for cell-imaging application.

Zheng N1, Ding S1, Zhou X2.
Colloids and surfaces. B, Biointerfaces.Colloids Surf B Biointerfaces.2016 Jun 1;142:123-9. doi: 10.1016/j.colsurfb.2016.02.037. Epub 2016 Feb 22.
Fluorescent carbon nanoparticle (FCN) is a new type of carbon-based materials. Because of its wide raw material sources, excellent optical properties and good biocompatibility, FCN is getting more and more attentions. However, its synthesis from resources at low cost under mild conditions is still a
PMID 26945164

Significant Pharmacokinetic Interactions Between Quinine and Ampicillin-Cloxacillin Combination.

Falade OB1, Falusi AG2, Olaniyi AA1, Ezeasor C3, Kwasi DA1, Babalola CP4,5.
Drugs in R&D.Drugs R D.2016 Jun;16(2):193-203. doi: 10.1007/s40268-016-0128-x.
INTRODUCTION: The co-existence of malaria with bacterial infections is common in the tropics, hence the concurrent use of antimalarials and antibiotics.OBJECTIVE: This study aimed to investigate the effect on pharmacokinetics and antimicrobial activity of co-administration of quinine and combined am
PMID 27020278