キネタゾン、キネサゾン
- 関
- Thiazide diuretics
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/17 15:09:02」(JST)
[Wiki en表示]
Quinethazone
|
| Systematic (IUPAC) name |
7-chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydroquinazoline-
6-sulfonamide |
| Clinical data |
| AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
| Legal status |
℞ Prescription only |
| Routes |
Oral |
| Identifiers |
| CAS number |
73-49-4 Y |
| ATC code |
C03BA02 |
| PubChem |
CID 6307 |
| DrugBank |
DB01325 |
| ChemSpider |
6068 Y |
| UNII |
455E0S048W Y |
| KEGG |
D00461 Y |
| ChEMBL |
CHEMBL1532 Y |
| Chemical data |
| Formula |
C10H12ClN3O3S |
| Mol. mass |
289.739 g/mol |
SMILES
- O=S(=O)(c2c(Cl)cc1c(C(=O)NC(N1)CC)c2)N
|
InChI
-
InChI=1S/C10H12ClN3O3S/c1-2-9-13-7-4-6(11)8(18(12,16)17)3-5(7)10(15)14-9/h3-4,9,13H,2H2,1H3,(H,14,15)(H2,12,16,17) Y
Key:AGMMTXLNIQSRCG-UHFFFAOYSA-N Y
|
| Y (what is this?) (verify) |
Quinethazone (INN, brand name Hydromox) is a thiazide-like diuretic used to treat hypertension. Common side effects include dizziness, dry mouth, nausea, and low potassium levels.
Synthesis
References
Cohen, Elliott; Klarberg, Betty; Vaughan, James R. (1960). Journal of the American Chemical Society 82 (11): 2731. doi:10.1021/ja01496a020.
|
Antihypertensives: diuretics (C03)
|
|
Sulfonamides
(and etacrynic acid) |
|
CA inhibitors (at PT)
|
|
|
|
Loop (Na-K-Cl at AL)
|
- Furosemide#
- Bumetanide
- Etacrynic acid
- Etozoline
- Muzolimine
- Piretanide
- Tienilic acid
- Torasemide
|
|
|
Thiazides (Na-Cl at DCT,
Calcium-sparing)
|
- Hydrochlorothiazide#
- Bendroflumethiazide
- Hydroflumethiazide
- Chlorothiazide
- Polythiazide
- Trichlormethiazide
- Cyclopenthiazide
- Methyclothiazide
- Cyclothiazide
- Mebutizide
|
|
|
Thiazide-likes (primarily DCT)
|
- Quinethazone
- Clopamide
- Chlortalidone
- Mefruside
- Clofenamide
- Metolazone
- Meticrane
- Xipamide
- Indapamide
- Clorexolone
- Fenquizone
|
|
|
| Potassium-sparing (at CD) |
|
ESC blockers
|
- Amiloride#
- Triamterene
- Benzamil
|
|
|
Aldosterone antagonists
|
- Spironolactone#
- Eplerenone
- Potassium canrenoate
- Canrenone
|
|
|
| Osmotic diuretics (PT, DL) |
|
|
Vasopressin receptor antagonists
(DCT and CD) |
- vaptans: Conivaptan
- Mozavaptan
- Satavaptan
- Tolvaptan
- tetracyclines: Demeclocycline
|
|
| Other |
- ethanol, isopropanol, 2M2B
- mercurial diuretic (Mersalyl, Meralluride)
- Theobromine
- Cicletanine
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
anat (a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot
|
noco/syva/cong/lyvd/tumr, sysi/epon, injr
|
proc, drug (C2s+n/3/4/5/7/8/9)
|
|
|
|
English Journal
- Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 - 2013).
- Carta F1, Supuran CT.
- Expert opinion on therapeutic patents.Expert Opin Ther Pat.2013;23(6):681-91. doi: 10.1517/13543776.2013.780598. Epub 2013 Mar 14.
- INTRODUCTION: The benzothiadiazines and high ceiling diuretics (hydrochlorothiazide, hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide and bumetanide) contain primary sulfamoyl moieties acting as zinc-binding groups in the metalloenzyme carbonic anhydrase (CA, EC 4
- PMID 23488823
- Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited--old leads for new applications?
- Temperini C1, Cecchi A, Scozzafava A, Supuran CT.
- Organic & biomolecular chemistry.Org Biomol Chem.2008 Jul 21;6(14):2499-506. doi: 10.1039/b800767e. Epub 2008 May 29.
- Sulfonamide diuretics such as hydrochlorothiazide, hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide and bumetanide were tested as inhibitors of the zinc enzyme carbonic anhydrases (CAs, EC 4.2.1.1). These drugs were discovered in a period when only isoform CA II w
- PMID 18600270
- Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.
- Temperini C1, Cecchi A, Scozzafava A, Supuran CT.
- Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2008 Apr 15;18(8):2567-73. doi: 10.1016/j.bmcl.2008.03.051. Epub 2008 Mar 20.
- Diuretics such as hydrochlorothiazide, hydroflumethiazide, quinethazone, metolazone, chlorthalidone, indapamide, furosemide, and bumetanide containing primary sulfamoyl moieties were reevaluated as inhibitors of 12 human carbonic anhydrases (hCAs, EC 4.2.1.1). These drugs considerably inhibit (low n
- PMID 18374572
Japanese Journal
- 16. 各種利尿剤の腎Mg Activated, Na-K Dependent ATPase活性に対する影響
- A quantum-biological analysis of thiazide diuretics and ethacrynic acid
- Quinethazone(Hydromox)の使用経験
★リンクテーブル★
[★]
- 英
- quinethazone
- 関
- キネタゾン
[★]
- 英
- quinethazone
- 関
- キネサゾン