- perform (a play), especially on a stage; "we are going to stage `Othello" (同)present, represent
- a section or portion of a journey or course; "then we embarked on the second stage of our Caribbean cruise" (同)leg
- a small platform on a microscope where the specimen is mounted for examination (同)microscope stage
- a large platform on which people can stand and can be seen by an audience; "he clambered up onto the stage and got the actors to help him into the box"
- any scene regarded as a setting for exhibiting or doing something; "All the worlds a stage"--Shakespeare; "it set the stage for peaceful negotiations"
- the theater as a profession (usually `the stage'
- plan, organize, and carry out (an event); "the neighboring tribe staged an invasion" (同)arrange
- not active or activated; "the quiescent level of centimeter wave-length solar radiation"
- (pathology) causing no symptoms; "a quiescent tumor"
- being quiet or still or inactive
- marked by a state of tranquil repose; "the quiescent melancholy of the town"
- attend a dance or a party without a female companion
- adult male deer
- getting rid of a stage of a multistage rocket
- travel by stagecoach
- written for or performed on the stage; "a staged version of the novel"
- (劇場・ホールなどの)『舞台』・on stage 舞台上で・《無冠詞》・off stage 舞台の陰で 《無冠詞》：ステージ;演壇;《the~》演劇;俳優業,演劇(舞台)の仕事 / (事件・活動などの)『舞台』,場所 / (発達などの)『段階』,時期 / (駅馬車などの止まる)駅,宿場;休憩地;(旅行における休憩地間の)旅程,行程 / =stagecoach / (多段ロケットの)段 / 〈劇〉‘を'『上演する』,〈試合など〉‘を'公開する / (特に劇的に)…‘を'実行する,やってのける
- 雄ジカ / 《米話》(社交的な集まりに)婦人を同伴しない男 / 男性用の,男性のみ出席する,男性向けの / 女性を同謀しないで
- 〈U〉足場 / 〈U〉〈C〉(劇の)上演,演出[方法]
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- GPI/AMF inhibition blocks the development of the metastatic phenotype of mature multi-cellular tumor spheroids.
- Gallardo-Pérez JC1, Rivero-Segura NA1, Marín-Hernández A1, Moreno-Sánchez R1, Rodríguez-Enríquez S2.Author information 1Departamento de Bioquímica, Instituto Nacional de Cardiología, Tlalpan, México DF 14080, México.2Departamento de Bioquímica, Instituto Nacional de Cardiología, Tlalpan, México DF 14080, México; Laboratorio de Medicina Traslacional, Instituto Nacional de Cancerología, México. Electronic address: email@example.com.AbstractEpithelial-mesenchymal transition (EMT) and cellular invasiveness are two pivotal processes for the development of metastatic tumor phenotypes. The metastatic profile of non-metastatic MCF-7 cells growing as multi-cellular tumor microspheroids (MCTSs) was analyzed by determining the contents of the EMT, invasive and migratory proteins, as well as their migration and invasiveness potential and capacity to secrete active cytokines such as the glucose phosphate isomerase/AMF (GPI/AMF). As for the control, the same analysis was also performed in MCF-7 and MDA-MB-231 (highly metastatic, MDA) monolayer cells, and in stage IIIB and IV human metastatic breast biopsies. The proliferative cell layers (PRL) of mature MCF-7 MCTSs, MDA monolayer cells and metastatic biopsies exhibited increased cellular contents (2-15 times) of EMT (β-catenin, SNAIL), migratory (vimentin, cytokeratin, and fibronectin) and invasive (MMP-1, VEGF) proteins versus MCF-7 monolayer cells, quiescent cell layers of mature MCF-7 MCTS and non-metastatic breast biopsies. The increase in metastatic proteins correlated with substantially elevated cellular abilities for migration (18-times) and invasiveness (13-times) and with the higher level (6-times) of the cytokine GPI/AMF in the extracellular medium of PRL, as compared to MCF-7 monolayer cells. Interestingly, the addition of the GPI/AMF inhibitors erythrose-4-phosphate or 6-phosphogluconate at micromolar doses significantly decreased its extracellular activity (>80%), with a concomitant diminution in the metastatic protein content and migratory tumor cell capacity, and with no inhibitory effect on tumor lactate production or toxicity on 3T3 mouse fibroblasts. The present findings provide new insights into the discovery of metabolic inhibitors to be used as complementary therapy against metastatic and aggressive tumors.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 Jun;1843(6):1043-53. doi: 10.1016/j.bbamcr.2014.01.013. Epub 2014 Jan 16.
- Epithelial-mesenchymal transition (EMT) and cellular invasiveness are two pivotal processes for the development of metastatic tumor phenotypes. The metastatic profile of non-metastatic MCF-7 cells growing as multi-cellular tumor microspheroids (MCTSs) was analyzed by determining the contents of the
- PMID 24440856
- Suppression of phase coarsening in immiscible, co-continuous polymer blends under high temperature quiescent annealing.
- Liu XQ1, Li RH, Bao RY, Jiang WR, Yang W, Xie BH, Yang MB.Author information 1State Key Laboratory of Polymer Materials Engineering, College of Polymer Science and Engineering, Sichuan University, Chengdu, 610065 Sichuan, China. firstname.lastname@example.org.AbstractThe properties of polymer blends greatly depend on the morphologies formed during processing, and the thermodynamic non-equilibrium nature of most polymer blends makes it important to maintain the morphology stability to ensure the performance stability of structural materials. Herein, the phase coarsening of co-continuous, immiscible polyamide 6 (PA6)-acrylonitrile-butadiene-styrene (ABS) blends in the melt state was studied and the effect of introduction of nano-silica particles on the stability of the phase morphology was examined. It was found that the PA6-ABS (50/50 w) blend maintained the co-continuous morphology but coarsened severely upon annealing at 230 °C. The coarsening process could be divided into two stages: a fast coarsening process at the initial stage of annealing and a second coarsening process with a relatively slow coarsening rate later. The reduction of the coarsening rate can be explained from the reduction of the global curvature of the interface. With the introduction of nano-silica, the composites also showed two stages of coarsening. However, the coarsening rate was significantly decreased and the phase morphology was stabilized. Rheological measurements indicated that a particle network structure was formed when the concentration of nano-silica particles was beyond 2 wt%. The particle network inhibited the movement of molecular chains and thus suppressed the coarsening process.
- Soft matter.Soft Matter.2014 May 28;10(20):3587-96. doi: 10.1039/c3sm53211a. Epub 2014 Mar 24.
- The properties of polymer blends greatly depend on the morphologies formed during processing, and the thermodynamic non-equilibrium nature of most polymer blends makes it important to maintain the morphology stability to ensure the performance stability of structural materials. Herein, the phase coa
- PMID 24663286
- Do Tetranychus urticae males avoid mating with familiar females?
- Yoshioka T1, Yano S.Author information 1Kyoto University, Japan.AbstractThe two-spotted spider mite Tetranychus urticae usually lives in kin groups under common webs. Since only the first mating results in fertilisation in female T. urticae, adult males guard quiescent deutonymph females, those at the stage immediately before maturation, to ensure paternity. Therefore, the cost of precopulatory guarding time seems considerable for males. Moreover, the fitness indices of daughters from intra-population crosses were significantly lower than those of daughters from inter-population crosses, indicating that inbreeding depression exists in T. urticae. Therefore, we hypothesised that T. urticae males should be choosy in guarding familiar females to avoid inbreeding depression. Furthermore, webs should be a key element of the environment shared by familiar individuals. In this study, we demonstrated the inbreeding avoidance mechanism of T. urticae males in relation to webs produced by familiar females (known webs) or unfamiliar females (unknown webs). Regardless of surrounding webs (known or unknown), males preferred unfamiliar to familiar females. We further examined whether males detect unfamiliar females by their webs. When males had experienced a female's web without encountering that female, they subsequently preferred females that did not produce the surrounding webs in which the choice experiment was conducted. Results suggest that putative kin recognition for inbreeding avoidance in T. urticae males is based on the relationship between webs and females, and not on the discrimination of webs in shared environments.
- The Journal of experimental biology.J Exp Biol.2014 Apr 15. [Epub ahead of print]
- The two-spotted spider mite Tetranychus urticae usually lives in kin groups under common webs. Since only the first mating results in fertilisation in female T. urticae, adult males guard quiescent deutonymph females, those at the stage immediately before maturation, to ensure paternity. Therefore,
- PMID 24737758
- Pseudo-CMOS with Re-Pull-Down Transistor: A Low Power Inverter Design for Thin-Film Transistors
- 0.8-/1.5-GHz-Band WCDMA HBT MMIC Power Amplifiers with an Analog Bias Control Scheme
- A 3.5-GHz-Band GaAs HBT Stage-Bypass-Type Step-Gain Amplifier Using Base-Collector Diode Switches and Its Application to a WiMAX HBT MMIC Power Amplifier Module
- Cells in this stage are metabolically active but no longer proliferate unless called on to do so depending on he requirement of the organism. Also called the Go ... The empty cafeteria was oddly quiescent. She became passive and ...
- Visible promontory and hypotympanic air cells. Subtotal perforation in quiescent stage with visible ossicles. Visible middle ear structures with concurrent osseous canal otomycosis. The tensor tympani tendon (arrow). Right subtotal ...
- resting state、stationary phase, stationary growth phase、interphase、resting phase, quiescent stage
- G0 phase
- 静止期 quiescent stage、休止期 resting stage
- quiescence、resting state、static state