ピリミドン
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- pyrimidinone
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/10/27 10:45:17」(JST)
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4-Pyrimidone
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Names |
IUPAC name
Pyrimidone
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Other names
Hydroxypyrimidine; Pyrimidinone
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Identifiers |
CAS Number
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3D model (JSmol)
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ChemSpider |
- 61686 2-Pyrimidone
- 19489 4-Pyrimidone
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Properties |
Chemical formula
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C4H4N2O |
Molar mass |
96.09 g·mol−1 |
Appearance |
White to light yellow powder |
Melting point |
163 to 168 °C (325 to 334 °F; 436 to 441 K) |
Hazards |
Main hazards |
Respiratory system, eye, skin irritation |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Y verify (what is YN ?) |
Infobox references |
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Pyrimidone is the name given to either of two heterocyclic compounds with the formula C4H4N2O: 2-pyrimidone and 4-pyrimidone. The compounds can also be called 2-hydroxypyrimidine or 4-hydroxypyrimidine respectively, based on a substituted pyrimidine, or 1,3-diazine, ring.
Derivatives
Derivatives of pyrimidone are the basis of many other biological molecules, including:
- Nucleobases, such as cytosine
- Barbiturates, such as metharbital
- Antiulcer drugs including temelastine, icotidine, donetidine, and lupitidine.
English Journal
- On the wavelength dependence of UV induced thymine photolesions: a synchrotron radiation circular dichroism study.
- Madsen MM1, Jones NC2, Nielsen SB2, Hoffmann SV2.
- Physical chemistry chemical physics : PCCP.Phys Chem Chem Phys.2016 Nov 9;18(44):30436-30443.
- Solar mutagenesis via the formation of thymine dimer photoproducts is a primary cause of skin cancer. The aim of this study is to provide a direct method for following the development of photolesions in thymine single strands and to determine how the formation of these photoproducts depends on the e
- PMID 27781221
- Transcriptional and Posttranslational Regulation of Nucleotide Excision Repair: The Guardian of the Genome against Ultraviolet Radiation.
- Park JM1, Kang TH2.
- International journal of molecular sciences.Int J Mol Sci.2016 Nov 4;17(11). pii: E1840.
- Ultraviolet (UV) radiation from sunlight represents a constant threat to genome stability by generating modified DNA bases such as cyclobutane pyrimidine dimers (CPD) and pyrimidine-pyrimidone (6-4) photoproducts (6-4PP). If unrepaired, these lesions can have deleterious effects, including skin canc
- PMID 27827925
- Facilitators and Repressors of Transcription Coupled DNA Repair in Saccharomyces cerevisiae.
- Li W1, Li S2.
- Photochemistry and photobiology.Photochem Photobiol.2016 Oct 31. doi: 10.1111/php.12655. [Epub ahead of print]
- Nucleotide excision repair is a well-conserved DNA repair pathway that removes bulky and/or helix-distorting DNA lesions, such as UV induced cyclobutane pyrimidine dimers and pyrimidine (6-4) pyrimidone photoproducts. Transcription coupled repair (TCR) is a subpathway of nucleotide excision repair t
- PMID 27796045
Japanese Journal
- A convenient route to new pyrrolo〔1,2-c〕pyrimidone, thiazolo〔3,4-c〕pyrimidone and pyrimido〔4,5-d〕pyridazine derivatives
- Kheder Nabila A.,Mabkhot Yahia N.,Farag Ahmad M.
- Heterocycles 78(4), 937-946, 2009-04-01
- NAID 40016499769
- Temperature-Sensitive Photoreactivation of Cyclobutane Thymine Dimer in Soybean
- YAMAMOTO Ayumi,TANBIR Najrana,HIROUCHI Tokuhisa,TERANISHI Mika,HIDEMA Jun,MORIOKA Hiroshi,YAMAMOTO Kazuo
- Journal of radiation research 49(2), 189-196, 2008-03-16
- … UV radiation induces the formation of two classes of photoproducts in DNA, the cyclobutane pyrimidine dimer (CPD) and the pyrimidine 6-4 pyrimidone photoproduct. …
- NAID 110006633661
- CPD Photolyase Gene from Spinacia oleracea : Repair of UV-Damaged DNA and Expression in Plant Organs
- YOSHIHARA Ryouhei,IMAKI Toshiyuki,HORI Manabu,WATANABE Chihiro,YAMAMOTO Kazuo,TAKIMOTO Koichi
- Journal of radiation research 46(2), 157-164, 2005-06-30
- … Specific damage to DNA caused by UV radiation involves the cyclobutyl pyrimidine dimers (CPD) and the pyrimidine (6-4) pyrimidone photoproducts. …
- NAID 110004041111
Related Links
- Structure, properties, spectra, suppliers and links for: pyrimidone. ... Predicted data is generated using the US Environmental Protection Agency’s EPISuite , for more information see their website. Log Octanol-Water Partition Coef ...
- << Previous Next >> Product Specification Pyrimidone Pyrimidone is the name given to either of two heterocyclic compounds with the formula C4H4N2O: 2-pyrimidone and 4-pyrimidon.
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