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English Journal

LPS and PAN-induced podocyte injury in an in vitro model of minimal change disease: changes in TLR profile.

Srivastava T, Sharma M, Yew KH, Sharma R, Duncan RS, Saleem MA, McCarthy ET, Kats A, Cudmore PA, Alon US, Harrison CJ.SourceSection of Nephrology, Children's Mercy Hospital and University of Missouri at Kansas City, Kansas City, MO, USA.
Journal of cell communication and signaling.J Cell Commun Signal.2012 Nov 17. [Epub ahead of print]
Minimal change disease (MCD), the most common idiopathic nephrotic syndrome in children, is characterized by proteinuria and loss of glomerular visceral epithelial cell (podocyte) ultrastructure. Lipopolysaccharide (LPS) and puromycin aminonucleoside (PAN) are used to study podocyte injury in models
PMID 23161414

Losartan preserves glomerular basement membrane anionic charge sites in a rat model of nephropathy.

Liu Y, Zhou D, Xiao X, Qin D, Zhong X, Xiong X, Inui K, Yoshimura A.SourceDepartment of Nephrology, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou - PR China.
Journal of nephrology.J Nephrol.2012 Oct 10:0. doi: 10.5301/jn.5000228. [Epub ahead of print]
Background: Disruption of the size and charge selectivity of the glomerular basement membrane (GBM) leads to proteinuria. Blood pressure medications suppress proteinuria by preserving GBM function. We investigated the mechanism of losartan, an angiotensin II receptor blocker (ARB), in a rat model of
PMID 23065922

Muroya Y, Ito O, Rong R, Takashima K, Ito D, Cao P, Nakamura Y, Joh K, Kohzuki M.SourceDept. of Internal Medicine and Rehabilitation Science, Tohoku Univ. Graduate School of Medicine, 1-1 Seiryo-chyo, Aoba-ku, Sendai 980-8574, Japan.
American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2012 Oct;303(7):F1070-9. doi: 10.1152/ajprenal.00365.2011. Epub 2012 Aug 8.
Proteinuria is considered to play an essential role in the progression of tubulointerstitial damage, which causes end-stage renal disease. Fatty acid-binding albumins are filtered through glomeruli and reabsorbed into proximal tubular epithelial cells (PTECs). However, the role of fatty acid metabol
PMID 22874759

海外論文紹介 : The Immunosuppressive Drug Mizoribine Directly Prevents Podocyte Injury in Puromycin Aminonucleoside Nephrosis

Tolvaptan, a selective oral vasopressin V2 receptor antagonist, ameliorates podocyte injury in puromycin aminonucleoside nephrotic rats

OKADA Tadashi,SAKAGUCHI Toshifumi,HATAMURA Ikuji,SAJI Fumie,NEGI Shigeo,OTANI Haruhisa,MURAGAKI Yasuteru,KAWACHI Hiroshi,SHIGEMATSU Takashi
Clinical and experimental nephrology 13(5), 438-446, 2009-10-01
NAID 10027226471