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a tumor derived from fibrous tissue of the meninges or choroid plexus or certain other structures associated with the brain; characterized by sandlike particles (同)sand_tumor

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/14 00:33:46」(JST)

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A psammoma body is a round collection of calcium, seen microscopically. The term is derived from the Greek word psammos meaning "sand."

Etiology[edit]

Psammoma bodies are associated with the papillary (nipple-like) histomorphology and are thought to arise from (1) the infarction and calcification of papillae tips and (2) calcification of intralymphatic tumor thrombi.^[1]

Association with lesions[edit]

Look up papillary in Wiktionary, the free dictionary.

Psammoma bodies are commonly seen in certain tumors such as:

Papillary thyroid carcinoma
Papillary renal cell carcinoma
Ovarian papillary serous cystadenocarcinoma^[2]
Endometrial adenocarcinomas (Papillary serous carcinoma ~3%-4%)
Meningiomas, in the central nervous system^[3]
Peritoneal and Pleural Mesothelioma
Somatostatinoma (pancreas)^[4]
Prolactinoma of the pituitary ^[5]
Mesothelioma, in membranes that line body cavities

Benign lesions[edit]

Micrograph of a psammomatous melanotic schwannoma with a psammoma body, as may be seen in Carney complex. H&E stain.

Psammoma bodies may be seen in:

Endosalpingiosis^[6]
Psammomatous melanotic schwannoma
Melanocytic nevus^[7]

Appearance[edit]

Psammoma bodies usually have a laminar appearance, are circular, acellular and basophilic.

References[edit]

^ Johannessen JV, Sobrinho-Simões M (September 1980). "The origin and significance of thyroid psammoma bodies". Lab. Invest. 43 (3): 287–96. PMID 7401638. Cite uses deprecated parameters (help)
^ Ovarian papillary serous cystadenocarcinoma at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer University School of Medicine. Retrieved July 2011
^ http://spinwarp.ucsd.edu/neuroweb/Text/br-300b.htm
^ 10.1148/rg.306105523, October 2010, RadioGraphics, 30, 1445-1464
^ Robbin's Pathology, Eight Ed
^ Hallman KB, Nahhas WA, Connelly PJ (September 1991). "Endosalpingiosis as a source of psammoma bodies in a Papanicolaou smear. A case report". J Reprod Med 36 (9): 675–8. PMID 1774734. Cite uses deprecated parameters (help)
^ Rapini, Ronald. Practical Dermatopathology. Elsevier Mosby, 2005, p. 10.

External links[edit]

Slides:

Meningioma
Thyroid cancer
Endometriosis (peritoneum)
Video of psammoma bodies in meningioma

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UpToDate Contents

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1. 上皮性卵巣癌：病理 epithelial ovarian cancer pathology
2. 甲状腺乳頭癌の概要 overview of papillary thyroid cancer
3. 子宮体癌：病理組織学および病因 endometrial carcinoma histopathology and pathogenesis
4. 原発不明の腺癌 adenocarcinoma of unknown primary site
5. ソマトスタチン産生腫瘍 somatostatinoma

English Journal

The transducible TAT-RIZ1-PR protein exerts histone methyltransferase activity and tumor-suppressive functions in human malignant meningiomas.

Ding MH1, Wang Z2, Jiang L1, Fu HL3, Gao J4, Lin XB1, Zhang CL3, Liu ZY5, Shi YF4, Qiu GZ1, Ma Y3, Cui DX3, Hu GH6, Jin WL7.
Biomaterials.Biomaterials.2015 Jul;56:165-78. doi: 10.1016/j.biomaterials.2015.03.058. Epub 2015 Apr 17.
Malignant meningiomas are a rare meningioma subtype and tend to have post-surgical recurrence. Significant endeavors have been taken to identify functional therapeutic targets to halt the growth of this aggressive cancer. We have recently discovered that RIZ1 is downregulated in high-grade meningiom
PMID 25934289

Meningiomas after cranial radiotherapy for childhood cancer: a single institution experience.

Felicetti F1, Fortunati N, Garbossa D, Biasin E, Rudà R, Daniele D, Arvat E, Corrias A, Fagioli F, Brignardello E.
Journal of cancer research and clinical oncology.J Cancer Res Clin Oncol.2015 Jul;141(7):1277-82. doi: 10.1007/s00432-015-1920-7. Epub 2015 Jan 22.
PURPOSE: Childhood cancer survivors (CCS) treated with cranial radiation therapy (CRT) are at risk of developing meningiomas. The aim of this study was to evaluate the cumulative incidence of meningiomas in a cohort of CCS who previously underwent CRT.METHODS: We considered all CCS who received CRT
PMID 25609074

Detection of Merkel cell polyomavirus large T-antigen sequences in human central nervous system tumors.

Sadeghi F1, Salehi-Vaziri M, Alizadeh A, Ghodsi SM, Bokharaei-Salim F, Fateh A, Monavari SH, Keyvani H.
Journal of medical virology.J Med Virol.2015 Jul;87(7):1241-7. doi: 10.1002/jmv.24178. Epub 2015 Mar 9.
Despite decades of epidemiological investigation, little is known about the etiology of the central nervous system (CNS) tumors, and few well-established risk factors have been recognized. This study tested the presence of Merkel cell polyomavirus (MCPyV), the only member of the Polyomaviridae famil
PMID 25754536

Japanese Journal

A study on psammoma body mineralization in meningiomas

WANG Changqiu,YANG Ruochen,LI Yan,XIONG Cuie,ZHAO Wenwen,LIU Jianying,ZHANG Bo,LU Anhuai
Journal of mineralogical and petrological sciences 106(5), 229-234, 2011-10-01
NAID 10029479653

Long-term oncological outcomes of ovarian serous carcinomas with psammoma bodies : A novel insight into the molecular pathogenesis of ovarian epithelial carcinoma

MOTOHARA Takeshi,TASHIRO Hironori,MIYAHARA Yo,SAKAGUCHI Isao,OHTAKE Hideyuki,KATABUCHI Hidetaka
Cancer science 101(6), 1550-1556, 2010-06-10
NAID 10026594146

Related Pictures

★リンクテーブル★

リンク元	「砂粒小体」「砂腫」「砂瘤」

「砂粒小体」

　　[★]

英: psammoma body
同: 砂粒体、砂腫、砂瘤 psammoma
関: [[]]

[show details]

砂粒小体 : 約 6,240 件
砂粒体 : 約 3,080 件

甲状腺乳頭癌
卵巣漿液性嚢胞腺癌
子宮漿液性腺癌

「砂腫」

　　[★]

英: psammoma, sand tumor
関: プサモーム、砂粒小体

「砂瘤」

　　[★]

英: psammoma
関: 砂粒小体

[1] Johannessen JV, Sobrinho-Simões M (September 1980). "The origin and significance of thyroid psammoma bodies". Lab. Invest. 43 (3): 287–96. PMID 7401638. Cite uses deprecated parameters (help)

[2] Ovarian papillary serous cystadenocarcinoma at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer University School of Medicine. Retrieved July 2011

[3] ttp://spinwarp.ucsd.edu/neuroweb/Text/br-300b.htm

[4] 10.1148/rg.306105523, October 2010, RadioGraphics, 30, 1445-1464

[5] Robbin's Pathology, Eight Ed

[pmid1774734-6] Hallman KB, Nahhas WA, Connelly PJ (September 1991). "Endosalpingiosis as a source of psammoma bodies in a Papanicolaou smear. A case report". J Reprod Med 36 (9): 675–8. PMID 1774734. Cite uses deprecated parameters (help)

[7] Rapini, Ronald. Practical Dermatopathology. Elsevier Mosby, 2005, p. 10.

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