WordNet
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- the organic processes (in a cell or organism) that are necessary for life (同)metabolic_process
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- 蛋白(たんばく)質
- 新陳代謝,物質交代
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/27 15:27:00」(JST)
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Protein metabolism denotes the various biochemical processes responsible for the synthesis of proteins and amino acids, and the breakdown of proteins (and other large molecules, too) by catabolism.
Dietary proteins are first broken down to individual amino acids by various enzymes and hydrochloric acid present in the gastro-intestinal tract.[1] These amino acids are further broken down to α-keto acids which can be recycled in the body for generation of energy, and production of glucose or fat or other amino acids. This break-down of amino acids to α-keto acids occurs in the liver by a process known as transamination, which follows a bimolecular ping pong mechanism.[2]
Contents
- 1 Protein synthesis
- 2 Protein breakdown
- 3 Amino acid metabolism
- 4 References
Protein synthesis
Main article: Protein biosynthesis
Protein biosynthesis relies on four processes:
- amino acid synthesis
- RNA synthesis
- transcription
- translation
Protein anabolism is the process by which protein are formed from amino acids (aka anabolic amino acid synthesis).
Protein breakdown
Main article: Proteolysis
Protein catabolism is the process by which proteins are broken down to their amino acids. This is also called proteolysis.
This can be followed by further amino acid degradation.
Amino acid metabolism
The following list contains links to information about the metabolism of individual amino acids.
- Positively charged side chains
- Arginine
- Histidine
- Lysine
- Negatively charged side chains
- Aspartic acid
- Glutamic acid
- Polar uncharged side chains
- Serine
- Threonine
- Asparagine
- Glutamine
- Special cases
- Cysteine
- Selenocysteine
- Glycine
- Proline
- Hydrophobic side chains
- Alanine
- Valine
- Isoleucine
- Leucine
- Methionine
- Phenylalanine
- Tyrosine
- Tryptophan
References
- ^ Mehta, S. Digestion of Dietary Proteins
- ^ Mehta, S. Metabolism of amino acids- bimolecular ping pong mechanism of transamination.
Metabolism catabolism, anabolism
|
|
General |
- Metabolic pathway
- Metabolic network
- Primary nutritional groups
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Energy
metabolism |
Aerobic respiration |
- Glycolysis → Pyruvate decarboxylation → Citric acid cycle → Oxidative phosphorylation (electron transport chain + ATP synthase)
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Anaerobic respiration |
- Electron acceptors are other than oxygen
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Fermentation |
- Glycolysis →
- Substrate-level phosphorylation
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Specific
paths |
Protein metabolism |
- Protein synthesis
- Catabolism
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|
Carbohydrate metabolism
(carbohydrate catabolism
and anabolism) |
Human |
- Glycolysis ⇄ Gluconeogenesis
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|
- Glycogenolysis ⇄ Glycogenesis
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|
- Pentose phosphate pathway
- Fructolysis
- Galactolysis
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|
|
|
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Nonhuman |
- Photosynthesis
- Anoxygenic photosynthesis
- Chemosynthesis
- Carbon fixation
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- Xylose metabolism
- Radiotrophism
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|
|
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Lipid metabolism
(lipolysis, lipogenesis) |
Fatty acid metabolism |
- Fatty acid degradation (Beta oxidation)
- Fatty acid synthesis
|
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Other |
- Steroid metabolism
- Sphingolipid metabolism
- Eicosanoid metabolism
- Ketosis
- Reverse cholesterol transport
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|
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Amino acid |
- Amino acid synthesis
- Urea cycle
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Nucleotide
metabolism |
- Purine metabolism
- Nucleotide salvage
- Pyrimidine metabolism
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Other |
- Metal metabolism
- Ethanol metabolism
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|
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Index of inborn errors of metabolism
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Description |
- Metabolism
- Enzymes and pathways: citric acid cycle
- pentose phosphate
- glycoproteins
- glycosaminoglycans
- phospholipid
- cholesterol and steroid
- sphingolipids
- eicosanoids
- amino acid
- urea cycle
- nucleotide
|
|
Disorders |
- Citric acid cycle and electron transport chain
- Glycoprotein
- Proteoglycan
- Fatty-acid
- Phospholipid
- Cholesterol and steroid
- Eicosanoid
- Amino acid
- Purine-pyrimidine
- Heme metabolism
- Symptoms and signs
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Treatment |
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Index of biochemical families
|
|
Carbohydrates |
- Alcohols
- Glycoproteins
- Glycosides
|
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Lipids |
- Eicosanoids
- Fatty acids
- Glycerides
- Phospholipids
- Sphingolipids
- Steroids
|
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Nucleic acids |
|
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Proteins |
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Other |
|
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UpToDate Contents
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English Journal
- Aqueous Two-Phase (PEG4000/Na2SO4) Extraction and Characterization of an Acid Invertase from Potato Tuber (Solanum tuberosum).
- Yuzugullu Y1, Duman YA.
- Preparative biochemistry & biotechnology.Prep Biochem Biotechnol.2015 Oct 3;45(7):696-711. doi: 10.1080/10826068.2014.943373.
- Invertases are key metabolic enzymes that catalyze irreversible hydrolysis of sucrose into fructose and glucose. Plant invertases have essential roles in carbohydrate metabolism, plant development, and stress responses. To study their isolation and purification from potato, an attractive system usef
- PMID 25127162
- Proteomics approach reveals mechanism underlying susceptibility of loquat fruit to sunburn during color changing period.
- Jiang JM1, Lin YX2, Chen YY2, Deng CJ1, Gong HW2, Xu QZ1, Zheng SQ3, Chen W4.
- Food chemistry.Food Chem.2015 Jun 1;176:388-95. doi: 10.1016/j.foodchem.2014.12.076. Epub 2014 Dec 27.
- The objective of this work was to investigate why loquat fruit peels are more sensitive to high temperature and strong sunlight, making them highly susceptible to sunburn, during the color changing period (CCP). Two dimensional gel electrophoresis (2-DE) of the fruit peel proteins was performed over
- PMID 25624247
Japanese Journal
- Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects
- メチオニン代謝変動に起因するメチル化修飾を介するがん細胞のエネルギー代謝制御機構
Related Links
- Animations. Protein Metabolism - Wiley: Home
- pro·tein me·tab·o·lism decomposition and synthesis of protein in the tissues. Synonym(s): proteometabolism protein metabolism the processes whereby protein foods are used by the body to make tissue proteins, together with the ...
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