プロスタグランジン類似体、プロスタグランジン類縁体
- 関
- prostaglandin analog、synthetic prostaglandin
WordNet
- something having the property of being analogous to something else (同)analog, parallel
- of a circuit or device having an output that is proportional to the input; "analogue device"; "linear amplifier" (同)analog, linear
- a potent substance that acts like a hormone and is found in many bodily tissues (and especially in semen); produced in response to trauma and may affect blood pressure and metabolism and smooth muscle activity
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/23 23:31:07」(JST)
[Wiki en表示]
Synthetic prostaglandin analogues are molecules which are manufactured to bind to a prostaglandin receptor.
Wider use of prostaglandin analogues is limited by unwanted side effects and their abortive potential.
Uses
- Prostaglandin analogues such as misoprostol are used in treatment of duodenal and gastric ulcers.[1] Misoprostol and other prostaglandin analogues protect the lining of the gastrointestinal tract from harmful stomach acid and are especially indicated for the elderly on continuous doses of NSAIDs.
- Prostaglandin analogues can also be used in the management of open-angle glaucoma. They reduce intra-ocular pressure by enhancing uveoscleral outflow and may also have some effect on the trabecular meshwork as well. Latanoprost, travoprost, unoprostone and bimatoprost are examples of prostaglandin analogues used in the management of open-angle glaucoma. In some countries such as Australia, they are now considered first line agents in open-angle glaucoma (rather than beta blockers)[2] However, a notable side effect is a possible darkening of iris color.
True synthetic prostaglandin E1 is also available pharmaceutically as alprostadil.
References
- ^ Zajac, P; Holbrook, A; Super, ME; Vogt, M (March–April 2013). "An overview: Current clinical guidelines for the evaluation, diagnosis, treatment, and management of dyspepsia". Osteopathic Family Physician 5 (2): 79–85. doi:10.1016/j.osfp.2012.10.005.
- ^ AMH 2008: Australian Medicines Handbook, 9th Edition Adelaide, S. Aust. : Australian Medicines Handbook, c2008.,
External links
- Prostaglandin Analogues at the US National Library of Medicine Medical Subject Headings (MeSH)
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Drugs for peptic ulcer and GERD/GORD (A02B)
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| H2 antagonists ("-tidine") |
- Cimetidine
- Famotidine
- Lafutidine
- Loxtidine
- Niperotidine
- Nizatidine
- Ranitidine
- Roxatidine
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| Prostaglandins (E)/analogues ("-prost-") |
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| Proton-pump inhibitors ("-prazole") |
- Dexlansoprazole
- Esomeprazole
- Ilaprazole
- Lansoprazole
- Omeprazole
- Pantoprazole
- Picoprazole
- Rabeprazole
- Tenatoprazole
- Timoprazole
|
|
| Potassium-competitive acid blockers ("-prazan") |
- Linaprazan
- Revaprazan
- Soraprazan
- Vonoprazan
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| Other |
- Acetoxolone
- Alginic acid
- Arbaclofen placarbil
- Carbenoxolone
- Cetraxate
- Gefarnate
- Lesogaberan
- Pirenzepine
- Proglumide
- Rebamipide
- Sucralfate
- Sulglicotide
- Telenzepine
- Teprenone
- Troxipide
- Zolimidine
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- See also: Helicobacter pylori eradication protocols
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Index of digestion
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| Description |
- Anatomy
- Physiology
- Development
|
|
| Disease |
- Congenital
- Neoplasms and cancer
- Inflammatory bowel disease
- Gluten sensitivity
- Other
- Symptoms and signs
- Blood tests
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| Treatment |
- Procedures
- Drugs
- anabolic steroids
- antacids
- diarrhoea and infection
- bile and liver
- functional gastrointestinal disorders
- laxatives
- peptic ulcer and reflux
- nausea and vomiting
- other
- Surgery
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Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)
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| Antiplatelet drugs |
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Glycoprotein IIb/IIIa inhibitors
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- Abciximab
- Eptifibatide
- Tirofiban
- Roxifiban
- Orbofiban
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|
|
ADP receptor/P2Y12 inhibitors
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- Thienopyridines
- Clopidogrel
- Prasugrel
- Ticlopidine
- Nucleotide/nucleoside analogs
- Cangrelor
- Elinogrel
- Ticagrelor
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|
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Prostaglandin analogue (PGI2)
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- Beraprost
- Iloprost
- Prostacyclin
- Treprostinil
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COX inhibitors
|
- Acetylsalicylic acid/Aspirin#
- Aloxiprin
- Carbasalate calcium
- Indobufen
- Triflusal
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|
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Thromboxane inhibitors
|
- Thromboxane synthase inhibitors
- Dipyridamole (+Aspirin)
- Picotamide
- Receptor antagonists
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|
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Phosphodiesterase inhibitors
|
- Cilostazol
- Dipyridamole
- Triflusal
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|
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Other
|
- Cloricromen
- Ditazole
- Vorapaxar
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|
|
| Anticoagulants |
|
Vitamin K antagonists
(inhibit II, VII, IX, X)
|
- Coumarins: Acenocoumarol
- Coumatetralyl
- Dicoumarol
- Ethyl biscoumacetate
- Phenprocoumon
- Warfarin#
- 1,3-Indandiones: Clorindione
- Diphenadione
- Phenindione
- Other: Tioclomarol
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|
|
Factor Xa inhibitors
(with some II inhibition)
|
Heparin group/
glycosaminoglycans/
(bind antithrombin) |
- Low molecular weight heparin
- Bemiparin
- Certoparin
- Dalteparin
- Enoxaparin
- Nadroparin
- Parnaparin
- Reviparin
- Tinzaparin‡
- Oligosaccharides
- Fondaparinux
- Idraparinux§
- Heparinoids
- Danaparoid
- Dermatan sulfate
- Sulodexide
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|
|
Direct Xa inhibitors
|
- Xabans
- Apixaban
- Betrixaban§
- Darexaban§
- Edoxaban
- Otamixaban§
- Rivaroxaban
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|
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Direct thrombin (IIa) inhibitors
|
- Bivalent: Hirudin
- Bivalirudin
- Desirudin
- Lepirudin
- Univalent: Argatroban
- Dabigatran
- Melagatran‡
- Ximelagatran‡
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|
|
Other
|
- Antithrombin III
- Defibrotide
- Protein C
- Ramatroban
- REG1
|
|
|
Thrombolytic drugs/
fibrinolytics |
- Plasminogen activators: r-tPA
- Alteplase
- Reteplase
- Tenecteplase
- UPA
- Anistreplase
- Monteplase
- Streptokinase#
- Other serine endopeptidases: Ancrod
- Brinase
- Fibrinolysin
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|
| Non-medicinal |
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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Index of cells from bone marrow
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|
| Description |
- Immune system
- Cells
- Physiology
- coagulation
- proteins
- granule contents
- colony-stimulating
- heme and porphyrin
|
|
| Disease |
- Red blood cell
- Monocyte and granulocyte
- Neoplasms and cancer
- Histiocytosis
- Symptoms and signs
- Blood tests
|
|
| Treatment |
- Transfusion
- Drugs
- thrombosis
- bleeding
- other
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Uterotonics/labor inducers/oxytocics (G02A)
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|
| Cervical ripening |
|
Ergot alkaloids
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- Ergometrine# (+oxytocin)
- Methylergometrine
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Prostaglandins and
analogues
|
- E: Misoprostol/E1#
- Gemeprost/E1
- Dinoprostone/E2
- Sulprostone/E2
- F: Dinoprost/F2α
- Carboprost/F2α
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|
|
| Contraction induction |
- Oxytocin#
- Carbetocin
- Demoxytocin
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
|
Index of obstetrics
|
|
| Description |
- Pregnancy
- Development
- Anatomy
|
|
| Disease |
- Pregnancy and childbirth
- Placenta and neonate
- Infections
- Symptoms and signs
|
|
| Treatment |
- Procedures
- Drugs
- oxytocins
- labor repressants
|
|
|
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Drugs used for glaucoma preparations and miosis (S01E)
|
|
| Sympathomimetics |
- Apraclonidine
- Brimonidine (+timolol)
- Clonidine
- Dipivefrine
- Epinephrine
|
|
| Parasympathomimetics |
| muscarinic |
|
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| muscarinic/nicotinic |
|
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| Acetylcholinesterase inhibitors |
- Demecarium
- Ecothiopate
- Stigmine (Fluostigmine
- Neostigmine
- Physostigmine)
- Paraoxon
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|
|
Carbonic anhydrase inhibitors/
(sulfonamides) |
- Acetazolamide
- Brinzolamide (+timolol)
- Diclofenamide
- Dorzolamide (+timolol)
- Methazolamide
|
|
| Beta blocking agents |
- Befunolol
- Betaxolol
- Carteolol
- Levobunolol
- Metipranolol
- Timolol
- Mepindolol
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|
| Prostaglandin analogues (F2α) |
- Bimatoprost (+timolol)
- Latanoprost (+timolol)
- Tafluprost
- Travoprost (+timolol)
- Unoprostone
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| Other agents |
|
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Index of the eye
|
|
| Description |
- Anatomy
- Physiology
- Phenomena
- appearance
- visual
- optical illusions
- proteins
- Development
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| Disease |
- Congenital
- Corneal dystrophy
- Neoplasms and cancer
- Other
- Symptoms and signs
|
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| Treatment |
- Procedures
- Drugs
- infection
- glaucoma and miosis
- mydriatics
- vascular
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Autacoids, unsaturated fatty acids: Eicosanoids
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| Precursor |
|
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| Prostanoids |
Prostaglandins (PG) and
analogues |
| Precursor |
|
|
| Active |
| D/J |
|
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| E/F |
- E2 (Dinoprostone): Enprostil
- Sulprostone
- E1 (Alprostadil): Misoprostol
- Gemeprost
- F2α (Dinoprost): Bimatoprost
- Carboprost
- Latanoprost
- Tafluprost
- Travoprost
- Unoprostone
|
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| I |
- I2 (Prostacyclin/Epoprostenol): Beraprost
- Iloprost
- Treprostinil
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|
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| Thromboxanes (TX) |
|
|
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| Leukotrienes (LT) |
| Precursor |
- Arachidonic acid 5-hydroperoxide
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| Initial |
|
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| SRS-A |
|
|
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| Eoxins (EX) |
| Precursor |
- Arachidonic acid 15-hydroperoxide
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| Eoxins |
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|
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| Nonclassic |
- Lipoxins (A4, B4)
- Virodhamine
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| By function |
- vasoconstriction
- vasodilation
- platelets: induce
- inhibit
- leukocytes: induce
- inhibit
- labor stimulation:
- PGE2 (Dinoprostone)
- PGF2α (Dinoprost)
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Index of inborn errors of metabolism
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|
| Description |
- Metabolism
- Enzymes and pathways: citric acid cycle
- pentose phosphate
- glycoproteins
- glycosaminoglycans
- phospholipid
- cholesterol and steroid
- sphingolipids
- eicosanoids
- amino acid
- urea cycle
- nucleotide
|
|
| Disorders |
- Citric acid cycle and electron transport chain
- Glycoprotein
- Proteoglycan
- Fatty-acid
- Phospholipid
- Cholesterol and steroid
- Eicosanoid
- Amino acid
- Purine-pyrimidine
- Heme metabolism
- Symptoms and signs
|
|
| Treatment |
|
|
Index of biochemical families
|
|
| Carbohydrates |
- Alcohols
- Glycoproteins
- Glycosides
|
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| Lipids |
- Eicosanoids
- Fatty acids
- Glycerides
- Phospholipids
- Sphingolipids
- Steroids
|
|
| Nucleic acids |
|
|
| Proteins |
|
|
| Other |
- Tetrapyrroles
- intermediates
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- High-fat diet increases O-GlcNAc levels in cerebral arteries: a link to vascular dysfunction associated with hyperlipidaemia/obesity?
- Lima VV1, Giachini FR2, Matsumoto T3, Li W4, Bressan AF2, Chawla D4, Webb RC4, Ergul A4, Tostes RC5.
- Clinical science (London, England : 1979).Clin Sci (Lond).2016 Jun 1;130(11):871-80. doi: 10.1042/CS20150777. Epub 2016 Feb 29.
- Obesity and high fat intake induce alterations in vascular function and structure. Aberrant O-GlcNAcylation (O-GlcNAc) of vascular proteins has been implicated in vascular dysfunction associated with cardiovascular and metabolic diseases. In the present study, we tested the hypothesis that high-fat
- PMID 26929437
- PGE2 receptor EP3 inhibits water reabsorption and contributes to polyuria and kidney injury in a streptozotocin-induced mouse model of diabetes.
- Hassouneh R1, Nasrallah R1, Zimpelmann J2, Gutsol A2, Eckert D1, Ghossein J1, Burns KD1,2, Hébert RL3.
- Diabetologia.Diabetologia.2016 Jun;59(6):1318-28. doi: 10.1007/s00125-016-3916-5. Epub 2016 Mar 19.
- AIMS/HYPOTHESIS: The first clinical manifestation of diabetes is polyuria. The prostaglandin E2 (PGE2) receptor EP3 antagonises arginine vasopressin (AVP)-mediated water reabsorption and its expression is increased in the diabetic kidney. The purpose of this work was to study the contribution of EP3
- PMID 26995650
- Circulating progesterone dynamics after intravaginal instillation of prostaglandin-F2α to lactating dairy cows.
- Wijma R1, Stangaferro ML1, Giordano JO2.
- Theriogenology.Theriogenology.2016 Jun;85(9):1660-8. doi: 10.1016/j.theriogenology.2016.01.025. Epub 2016 Feb 4.
- Our objectives were to evaluate circulating progesterone (P4) concentration dynamics and test the feasibility of inducing luteal regression after intravaginal (IVG) instillation of the PGF2α analogue dinoprost (PGF) in lactating dairy cows. In two experiments, cows were synchronized using the Ovsyn
- PMID 26928644
Japanese Journal
- プロスタグランジン関連薬へのブリモニジン点眼液追加後1年間における有効性と安全性 (特集 第68回日本臨床眼科学会講演集(2))
- プロスタグランジン関連薬単剤使用例へのブリモニジン点眼液の追加後6ヵ月間における有効性と安全性 (第24回日本緑内障学会)
- A randomized, double-blinded, placebo-controlled, multicenter trial, healing effect of rebamipide in patients with low-dose aspirin and/or non-steroidal anti-inflammatory drug induced small bowel injury
- Kurokawa Sei,Katsuki Shinichi,Fujita Tomoki,Saitoh Yusuke,Ohta Hidetoshi,Nishikawa Kouji,Sato Yasushi,Sato Yasuhiro,Ohira Koji,Yamada Masataka,Kato Mototsugu
- Journal of gastroenterology 49(2), 239-244, 2014-02
- … Several reports showed the preventive effect of prostaglandin analogue or inducer using healthy subjects who took NSAIDs. …
- NAID 120005553660
Related Links
- Prostaglandin analogue A class of drugs that are similar in structure and function to prostaglandin. Mentioned in: Glaucoma ... At least three companies have sustained release systems delivering prostaglandin analogues in phase II ...
- Prostaglandin analogue A class of drugs that are similar in structure and function to prostaglandin. Mentioned in: Glaucoma ... Bauman has also been at the forefront of Low Level Laser Therapy for hair growth, topical prostaglandin ...
Related Pictures
★リンクテーブル★
[★]
- 関
- prostaglandin analogue、synthetic prostaglandin
[★]
- 関
- prostaglandin analog、prostaglandin analogue
[★]
- 関
- analogue、derivate、derivative、relative
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5分間隔集計
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REDIRHOST
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ドメインレポート
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リンク元レポート
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リダイレクトされたリンク元URLレポート
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仮想ホストリダイレクションレポート
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仮想ホスト不成功レポート
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REDIRUSER
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不成功ユーザレポート
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状態コードレポート
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[★]
- 関
- analog、derivative、relative
[★]
プロスタグランジン prostaglandins PG
[★]
プロスタグランジン