WordNet

a proteolytic enzyme secreted by the kidneys; catalyzes the formation of angiotensin and thus affects blood pressure

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Antihypertensive effects of lactoferrin hydrolyzates: Inhibition of angiotensin- and endothelin-converting enzymes.

Fernández-Musoles R, Salom JB, Martínez-Maqueda D, López-Díez JJ, Recio I, Manzanares P.SourceDepartamento de Biotecnología de Alimentos, Instituto de Agroquímica y Tecnología de Alimentos, Consejo Superior de Investigaciones Científicas (CSIC), Ave. Agustín Escardino 7, 46980 Paterna, Valencia, Spain.
Food chemistry.Food Chem.2013 Aug 15;139(1-4):994-1000. doi: 10.1016/j.foodchem.2012.12.049. Epub 2013 Jan 16.
The potential of bovine lactoferrin (LF) as a source of antihypertensive peptides acting on the renin-angiotensin system (RAS) and the endothelin (ET) system as dual vasopeptidase inhibitors has been examined. For this purpose enzymatic LF hydrolyzates (LFHs) were generated by trypsin and proteinase
PMID 23561201

The direct renin inhibitor aliskiren improves vascular remodelling in transgenic rats harbouring human renin and angiotensinogen genes.

Savoia C, Arrabito E, Parente R, Sada L, Madaro L, Nicoletti C, Zezza L, Alonzo A, Rubattu S, Michelini S, Muller DN, Volpe M.Source*Division of Cardiology, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Clinical science (London, England : 1979).Clin Sci (Lond).2013 Aug 1;125(4):183-9. doi: 10.1042/CS20120395.
In the present study, we tested the hypothesis that chronic treatment with the direct rennin inhibitor aliskiren improves the remodelling of resistance arteries in dTGR (double-transgenic rats). dTGR (5 weeks) were treated with aliskiren (3 mg/kg of body mass per day) or ramipril (1 mg/kg of body
PMID 23438195

Gironacci MM, Longo Carbajosa NA, Goldstein J, Cerrato BD.SourceDepartamento de Química Biológica, Instituto de Química y Fisicoquímica Biológicas-CONICET, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina. mariela@qb.ffyb.uba.ar
Clinical science (London, England : 1979).Clin Sci (Lond).2013 Jul 1;125(2):57-65. doi: 10.1042/CS20120652.
Ang-(1-7) [angiotensin-(1-7)] constitutes an important functional end-product of the RAS (renin-angiotensin system) endogenously formed from AngI (angiotensin I) or AngII (angiotensin II) through the catalytic activity of ACE2 (angiotensin-converting enzyme 2), prolyl carboxypeptidase, neutral endop
PMID 23530669

Expression of (pro)renin receptor in breast cancers and its effect on cancercell proliferation

In Situ Hybridization Method Reveals (Pro)renin Receptor Expressing Cells in the Pituitary Gland of Rats: Correlation with Anterior Pituitary Hormones

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ACTA HISTOCHEMICA ET CYTOCHEMICA 46(1), 47-50, 2013
… Expression of (pro)renin receptor ((P)RR), a specific receptor for renin and prorenin, was studied in rat pituitary gland. …
NAID 130003361068