関: prilocaine、propitocaine hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/08 01:07:11」(JST)

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Prilocaine /ˈpraɪlɵkeɪn/ is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Löfgren. In its injectable form (trade name Citanest), it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used for intravenous regional anaesthesia (IVRA).

In some patients, a metabolite of prilocaine may cause the unusual side effect of methemoglobinemia, which may be treated with methylene blue.

Maximum dosage for dental use: 8.0 mg/kg (2.7 mg/lb), with a maximum dose of 500 mg.

It is given as a combination with the vasoconstrictor epinephrine under the trade name Citanest Forte.

Compendial status[edit]

United States Pharmacopeia 31 ^[1]

Notes[edit]

^ The United States Pharmacopeial Convention. "Revision Bulletin: Lidocaine and Prilocaine Cream–Revision to Related Compounds Test". Retrieved 10 July 2009.

English Journal

Immune system participates in brain regeneration and restoration of reproduction in the earthworm Dendrobaena veneta.

Molnar L1, Pollak E1, Skopek Z2, Gutt E2, Kruk J3, Morgan AJ4, Plytycz B5.
Developmental and comparative immunology.Dev Comp Immunol.2015 Oct;52(2):269-79. doi: 10.1016/j.dci.2015.04.001. Epub 2015 Apr 8.
Earthworm decerebration causes temporary inhibition of reproduction which is mediated by certain brain-derived neurohormones; thus, cocoon production is an apposite supravital marker of neurosecretory center functional recovery during brain regeneration. The core aim of the present study was to inve
PMID 25863277

The Importance of the Trigeminal Cardiac Reflex in Rhinoplasty Surgery.

Özçelik D1, Toplu G, Türkseven A, Sezen G, Ankarali H.
Annals of plastic surgery.Ann Plast Surg.2015 Aug;75(2):213-8. doi: 10.1097/SAP.0000000000000061.
BACKGROUND: Trigeminocardiac reflex (TCR) consists of bradycardia or asystole along with hypotension and apnea coinciding with stimulation of the trigeminal nerve. During rhinoplasty procedures, we noticed that local anesthetic solution (LAS) application to the columellar area results in bradycardia
PMID 24374394

Comparison of the effects of sodium hyaluronate-chondroitin sulphate and corticosteroid in the treatment of lateral epicondylitis: a prospective randomized trial.

Tosun HB1, Gumustas S, Agir I, Uludag A, Serbest S, Pepele D, Ertem K.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.J Orthop Sci.2015 Jul 3. [Epub ahead of print]
BACKGROUND: Hyaluronic acid and glycosaminoglycans have shown positive effects in improving lateral epicondylitis and other tendinosis conditions. Therefore, we designed a prospective, randomized study to compare the effects of a combined sodium hyaluronate and chondroitin sulfate (HA + CS) inject
PMID 26133944

Japanese Journal

Severe methemoglobinemia after dental anesthesia : a warning about propitocaine-induced methemoglobinemia in neonates

DOKO Yukari,IRANAMI Hiroshi,FUJII Keisuke,YAMAZAKI Akinori,SHIMOGAI Manabu,HATANO Yoshio
Journal of anesthesia 24(6), 935-937, 2010-12-20
NAID 10027741663

アドレナリン添加リドカインとフェリプレシン添加プロピトカインの使い分けは?

一戸達也
齒科學報 109(4), 403-404, 2009-08-30
NAID 10025673366

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リンク元	「プロピトカイン」「prilocaine」
拡張検索	「propitocaine hydrochloride」

「プロピトカイン」

Prilocaine
Systematic (IUPAC) name
	(RS)-N-(2-methylphenyl)-N2-propylalaninamide
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a603026
Pregnancy cat.	B (U.S.)
Legal status	?
Pharmacokinetic data
Protein binding	55%
Metabolism	Hepatic and renal
Half-life	10-150 minutes, longer with impaired hepatic or renal function
Identifiers
CAS number	721-50-6
ATC code	N01BB04
PubChem	CID 4906
DrugBank	DB00750
ChemSpider	4737
UNII	046O35D44R
KEGG	D00553
ChEBI	CHEBI:8404
ChEMBL	CHEMBL1194
Chemical data
Formula	C13H20N2O
Mol. mass	220.311 g/mol
	SMILES O=C(Nc1ccccc1C)C(NCCC)C;
	InChI InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16) ; Key:MVFGUOIZUNYYSO-UHFFFAOYSA-N ;
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英: propitocaine、propitocaine hydrochloride
関: プリロカイン、塩酸プロピトカイン

「prilocaine」

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プリロカイン

関: propitocaine

「propitocaine hydrochloride」

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塩酸プロピトカイン

関: propitocaine

[rblp-1] The United States Pharmacopeial Convention. "Revision Bulletin: Lidocaine and Prilocaine Cream–Revision to Related Compounds Test". Retrieved 10 July 2009.

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propitocaine