promutagen

English Journal

Diethylnitrosamine genotoxicity evaluated in sprague dawley rats using pig-a mutation and reticulocyte micronucleus assays.

Avlasevich SL1, Phonethepswath S, Labash C, Carlson K, Torous DK, Cottom J, Bemis JC, MacGregor JT, Dertinger SD.
Environmental and molecular mutagenesis.Environ Mol Mutagen.2014 Jun;55(5):400-6. doi: 10.1002/em.21862. Epub 2014 Feb 27.
Diethylnitrosamine (DEN) is a genotoxic carcinogen, but in vivo DNA-damaging activities are not usually evident in hematopoietic cells because the short-lived active metabolite is formed mainly in the liver. DEN therefore represented an interesting case for evaluating the performance characteristics
PMID 24574022

Crosstalk among dietary polyunsaturated fatty acids, urolithiasis, chronic inflammation, and urinary tract tumor risk.

Eynard AR1, Navarro A.
Nutrition (Burbank, Los Angeles County, Calif.).Nutrition.2013 Jul-Aug;29(7-8):930-8. doi: 10.1016/j.nut.2012.12.014. Epub 2013 Apr 14.
Based on a consistent bulk of experimental and epidemiologic works, we proposed that abnormal metabolism and/or dietary deprivation of essential polyunsaturated fatty acids by inducing a chronic and subclinical essential fatty acid deficiency (EFAD) in urothelial cell membranes may enhance the risk
PMID 23594581

Metabolite profiling of polyphenols in a Terminalia chebula Retzius ayurvedic decoction and evaluation of its chemopreventive activity.

Pellati F1, Bruni R, Righi D, Grandini A, Tognolini M, Pio Prencipe F, Poli F, Benvenuti S, Del Rio D, Rossi D.
Journal of ethnopharmacology.J Ethnopharmacol.2013 May 20;147(2):277-85. doi: 10.1016/j.jep.2013.02.025. Epub 2013 Mar 15.
ETHNOPHARMACOLOGICAL RELEVANCE: The decoction of Terminalia chebula fruit is an ayurvedic remedy whose prolonged oral administration is prized as a generic intestinal and hepatic detoxifying agent. Its administration is suggested also under the perspective of a reduced risk of cancer, metabolic and
PMID 23506992

Astaxanthin can alter CYP1A-dependent activities via two different mechanisms : Induction of protein expression and inhibition of NADPH P450 reductase dependent electron transfer

Ohno Marumi,Darwish Wageh S.,Ikenaka Yoshinori,Miki Wataru,Ishizuka Mayumi
Food and Chemical Toxicology 49(6), 1285-1291, 2011-06
… To investigate the effect of Ax on the metabolic activation of a typical promutagen, benzo[a]pyrene by CYP1A, we orally administrated Ax (100 mg / kg body weight / day for 3 days) to male Wistar rats. …
NAID 120003089254

Screening of the Desmutagenic Capacity of an Extract from Crude Drug by Spore Rec-Assay

Ueno Seiichi,Aoki Kazuko,Ishizaki Mutsuo
Journal of health science 46(1), 29-34, 2000-02-01
We investigated the desmutagenic action of extracts from Smilax rhizome, Mulberry bark and Berchemia racemosa on Trp-P-1 and Trp-P-2 by means of spore rec-assay. The results obtained are as follows : …
NAID 110003641594

河井一明
Journal of health science 45(1), 28-36, 1999-02-28
Since early 1980s Drosophila melanogaster larvae heterozygous for recessive visible markers and those with defective DNA repair capability have been intensively used as simple in vivo testers of mutag …
NAID 110003641492